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Volumn 22, Issue 12, 2012, Pages 877-886

Identification of drug targets by chemogenomic and metabolomic profiling in yeast

Author keywords

chemogenomics; metabolomics; pharmacology

Indexed keywords

ANTIFUNGAL AGENT; ERGOSTEROL; FLUCONAZOLE; HARMINE; MEBHYDROLIN; NATURAL PRODUCT; TERBINAFINE; TOTAROL; UNCLASSIFIED DRUG;

EID: 84870362521     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32835aa888     Document Type: Article
Times cited : (8)

References (31)
  • 4
    • 47649093352 scopus 로고    scopus 로고
    • An integrated platform of genomic assays reveals small-molecule bioactivities
    • Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, et al. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol 2008; 4:498-506.
    • (2008) Nat Chem Biol , vol.4 , pp. 498-506
    • Hoon, S.1    Smith, A.M.2    Wallace, I.M.3    Suresh, S.4    Miranda, M.5    Fung, E.6
  • 7
    • 77956274547 scopus 로고    scopus 로고
    • High-throughput Profiling of Amino Acids in Strains of the Saccharomyces Cerevisiae Deletion Collection
    • Cooper SJ, Finney GL, Brown SL, Nelson SK, Hesselberth J, MacCoss MJ, et al. High-throughput profiling of amino acids in strains of the Saccharomyces cerevisiae deletion collection. Genome Res 2010; 20:1288-1296.
    • (2010) Genome Res , vol.20 , pp. 1288-1296
    • Cooper, S.J.1    Finney, G.L.2    Brown, S.L.3    Nelson, S.K.4    Hesselberth, J.5    MacCoss, M.J.6
  • 8
    • 33847377098 scopus 로고    scopus 로고
    • From exogenous to endogenous: The inevitable imprint of mass spectrometry in metabolomics
    • DOI 10.1021/pr060505+
    • Want EJ, Nordstrom A, Morita H, Siuzdak G. From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J Proteome Res 2007; 6:459-468. (Pubitemid 46340150)
    • (2007) Journal of Proteome Research , vol.6 , Issue.2 , pp. 459-468
    • Want, E.J.1    Nordstrom, A.2    Morita, H.3    Siuzdak, G.4
  • 9
    • 48849114188 scopus 로고    scopus 로고
    • Gas chromatography/mass spectrometry in metabolomic profiling of biological fluids
    • Pasikanti KK, Ho PC, Chan ECY. Gas chromatography/mass spectrometry in metabolomic profiling of biological fluids. J Chromatogr B 2008; 871:202-211.
    • (2008) J Chromatogr B , vol.871 , pp. 202-211
    • Pasikanti, K.K.1    Ho, P.C.2    Chan, E.C.Y.3
  • 10
    • 66149094266 scopus 로고    scopus 로고
    • Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome
    • Guo K, Li L. Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Anal Chem 2009; 81:3919-3932.
    • (2009) Anal Chem , vol.81 , pp. 3919-3932
    • Guo, K.1    Li, L.2
  • 11
    • 0034254574 scopus 로고    scopus 로고
    • Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry
    • DOI 10.1021/ac991142i
    • Fiehn O, Kopka J, Trethewey RN, Willmitzer L. Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Anal Chem 2000; 72:3573-3580. (Pubitemid 30614934)
    • (2000) Analytical Chemistry , vol.72 , Issue.15 , pp. 3573-3580
    • Fiehn, O.1    Kopka, J.2    Trethewey, R.N.3    Willmitzer, L.4
  • 12
    • 0032882718 scopus 로고    scopus 로고
    • Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    • Ghannoum MA, Rice LB. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 1999; 12:501-517. (Pubitemid 29484744)
    • (1999) Clinical Microbiology Reviews , vol.12 , Issue.4 , pp. 501-517
    • Ghannoum, M.A.1    Rice, L.B.2
  • 13
    • 67849126733 scopus 로고    scopus 로고
    • Chemogenomic approaches to elucidation of gene function and genetic pathways
    • Pierce SE, Davis RW, Nislow C, Giaever G. Chemogenomic approaches to elucidation of gene function and genetic pathways. Methods Mol Biol 2009; 548:115-143.
    • (2009) Methods Mol Biol , vol.548 , pp. 115-143
    • Pierce, S.E.1    Davis, R.W.2    Nislow, C.3    Giaever, G.4
  • 14
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 15
    • 72449186517 scopus 로고    scopus 로고
    • FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • Kind T, Wohlgemuth G, Lee do Y, Lu Y, Palazoglu M, Shahbaz S, Fiehn O. FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal Chem 2009; 81:10038-10048.
    • (2009) Anal Chem , vol.81 , pp. 10038-10048
    • Kind, T.1    Wohlgemuth, G.2    Lee Do, Y.3    Lu, Y.4    Palazoglu, M.5    Shahbaz, S.6    Fiehn, O.7
  • 16
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B 1995; 57:289-300.
    • (1995) J R Stat Soc Series B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 19
    • 33846387040 scopus 로고    scopus 로고
    • Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
    • DOI 10.1016/j.bbagen.2006.07.018, PII S0304416506002145
    • Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochim Biophys Acta 2007; 1770:467-477. (Pubitemid 46136743)
    • (2007) Biochimica et Biophysica Acta - General Subjects , vol.1770 , Issue.3 , pp. 467-477
    • Lepesheva, G.I.1    Waterman, M.R.2
  • 20
    • 37549014195 scopus 로고    scopus 로고
    • Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51
    • Craven RJ, Mallory JC, Hand RA. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J Biol Chem 2007; 282:36543-36551.
    • (2007) J Biol Chem , vol.282 , pp. 36543-36551
    • Craven, R.J.1    Mallory, J.C.2    Hand, R.A.3
  • 21
    • 0026663089 scopus 로고
    • Antibacterial activity of totarol and its potentiation
    • Kubo I, Muroi H, Himejima M. Antibacterial activity of totarol and its potentiation. J Nat Prod 1992; 55:1436-1440.
    • (1992) J Nat Prod , vol.55 , pp. 1436-1440
    • Kubo, I.1    Muroi, H.2    Himejima, M.3
  • 23
    • 0031003993 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase A by β-Carboline derivatives
    • DOI 10.1006/abbi.1996.9771
    • Kim H, Sablin SO, Ramsay RR. Inhibition of monoamine oxidase A by beta-carboline derivatives. Arch Biochem Biophys 1997; 337:137-142. (Pubitemid 27198065)
    • (1997) Archives of Biochemistry and Biophysics , vol.337 , Issue.1 , pp. 137-142
    • Hoon, K.1    Sablin, S.O.2    Ramsay, R.R.3
  • 24
    • 79954605221 scopus 로고    scopus 로고
    • Harmine A Natural Beta-carboline Alkaloid Upregulates Astroglial Glutamate Transporter Expression
    • Li Y, Sattler R, Yang EJ, Nunes A, Ayukawa Y, Akhtar S, et al. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology 2010; 60:1168-1175.
    • (2010) Neuropharmacology , vol.60 , pp. 1168-1175
    • Li, Y.1    Sattler, R.2    Yang, E.J.3    Nunes, A.4    Ayukawa, Y.5    Akhtar, S.6
  • 25
    • 21844447128 scopus 로고    scopus 로고
    • Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent
    • DOI 10.1016/j.phytochem.2005.04.035, PII S0031942205002104
    • Jahaniani F, Ebrahimi SA, Rahbar-Roshandel N, Mahmoudian M. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry 2005; 66:1581-1592. (Pubitemid 40950551)
    • (2005) Phytochemistry , vol.66 , Issue.13 , pp. 1581-1592
    • Jahaniani, F.1    Ebrahimi, S.A.2    Rahbar-Roshandel, N.3    Mahmoudian, M.4
  • 26
    • 0019726260 scopus 로고
    • The β-carbolines (Harmanes): A new class of endogenous compounds: Their relevance for the pathogenesis and treatment of psychiatric and neurological diseases
    • Rommelspacher H. The beta-carbolines (harmanes)-a new class of endogenous compounds: their relevance for the pathogenesis and treatment of psychiatric and neurological diseases. Pharmacopsychiatria 1981; 14:117-125. (Pubitemid 11006309)
    • (1981) Pharmacopsychiatria , vol.14 , Issue.4 , pp. 117-125
    • Rommelspacher, H.1
  • 27
    • 0029069608 scopus 로고
    • Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril)
    • Waitzinger J, Lenders H, Pabst G, Reh C, Ulbrich E. Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril). Int J Clin Pharmacol Ther 1995; 33:373-383.
    • (1995) Int J Clin Pharmacol Ther , vol.33 , pp. 373-383
    • Waitzinger, J.1    Lenders, H.2    Pabst, G.3    Reh, C.4    Ulbrich, E.5
  • 28
    • 0035900685 scopus 로고    scopus 로고
    • A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: Acetylglutamate synthase activity requires complex formation with acetylglutamate kinase
    • Abadjieva A, Pauwels K, Hilven P, Crabeel M. A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. J Biol Chem 2001; 276:42869-42880.
    • (2001) J Biol Chem , vol.276 , pp. 42869-42880
    • Abadjieva, A.1    Pauwels, K.2    Hilven, P.3    Crabeel, M.4
  • 29
    • 75549090505 scopus 로고    scopus 로고
    • The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
    • Caspi R, Altman T, Dale JM, Dreher K, Fulcher CA, Gilham F, et al. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res 2010; 38 (Database issue):D473-D479.
    • (2010) Nucleic Acids Res , vol.38
    • Caspi, R.1    Altman, T.2    Dale, J.M.3    Dreher, K.4    Fulcher, C.A.5    Gilham, F.6
  • 30
    • 62249177821 scopus 로고    scopus 로고
    • Metabolites in safety testing (MIST): Considerations of mechanisms of toxicity with dose, abundance, and duration of treatment
    • Smith DA, Obach RS. Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment. Chem Res Toxicol 2009; 22:267-279.
    • (2009) Chem Res Toxicol , vol.22 , pp. 267-279
    • Smith, D.A.1    Obach, R.S.2
  • 31
    • 34047266790 scopus 로고    scopus 로고
    • Applying mechanisms of chemical toxicity to predict drug safety
    • DOI 10.1021/tx600260a
    • Guengerich FP, MacDonald JS. Applying mechanisms of chemical toxicity to predict drug safety. Chem Res Toxicol 2007; 20:344-369. (Pubitemid 46548682)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.3 , pp. 344-369
    • Guengerich, F.P.1    MacDonald, J.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.