Volumetric modulated arc therapy with flattening filter free beams for isolated abdominal/pelvic lymph nodes: Report of dosimetric and early clinical results in oligometastatic patients

Radiation Oncology

Volumn 7, Issue 1, 2012, Pages

  Alongi, Filippo ^a   Fogliata, Antonella ^b   Clerici, Elena ^a   Navarria, Pierina ^a   Tozzi, Angelo ^a   Comito, Tiziana ^a   Ascolese, Anna Maria ^a   Clivio, Alessandro ^b   Lobefalo, Francesca ^a   Reggiori, Giacomo ^a   Cozzi, Luca ^b   Mancosu, Pietro ^a   Tomatis, Stefano ^a   Scorsetti, Marta ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

Abdominal pelvic lymphnodes; FFF; VMAT

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DOSIMETRY; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; LYMPH NODE METASTASIS; MALE; PARAAORTIC LYMPH NODE; PELVIS LYMPH NODE; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; SCORING SYSTEM; STEREOTACTIC BODY RADIATION THERAPY; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; DOSE FRACTIONATION; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOMETRY; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84870360325     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-7-204     Document Type: Article

References (25)

1. Weichselbaum RR, Hellman S. Oligometastases revisited. Nat Rev Clin Oncol 2011, 8:378-382.
2. Rubin P, Brasacchio R, Katz A. Solitary metastases: Illusion versus reality. Semin Radiat Oncol 2006, 16:120-130. 10.1016/j.semradonc.2005.12.007, 16564447.
3. Alongi F, Arcangeli S, Filippi AR, Ricardi U, Scorsetti M. Review and Uses of Stereotactic Body Radiation Therapy for Oligometastases. Oncologist Oncologist. in press.
4. Scorsetti M, Bignardi M, Alongi F, Fogliata A, Mancosu P, Navarria P, Castiglioni S, Pentimalli S, Tozzi A, Cozzi L. Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: feasibility and clinical preliminary results. Acta Oncol 2011, 50:528-538. 10.3109/0284186X.2011.558522, 21338272.
5. Bignardi M, Navarria P, Mancosu P, Cozzi L, Fogliata A, Tozzi A, Castiglioni S, Carnaghi C, Tronconi MC, Santoro A, Scorsetti M. Clinical outcome of hypofractionated stereotactic radiotherapy for abdominal lymph node metastases. Int J Radiat Oncol Biol Phys 2011, 81:831-838. 10.1016/j.ijrobp.2010.05.032, 20800375.
6. Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008, 35:310-317. 10.1118/1.2818738, 18293586.
7. Ong C, Palma D, Verbakel W, Slotman BJ, Senan S. Treatment of large stage I-II lung tumors using stereotactic body radiotherapy (SBRT): planning considerations and early toxicity. Radiother Oncol 2010, 97:431-436. 10.1016/j.radonc.2010.10.003, 20971523.
8. Bignardi M, Cozzi L, Fogliata A, Lattuada P, Mancosu P, Navarria P, Urso G, Vigorito S, Scorsetti M. Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodes. Int J Radiat Oncol Biol Phys 2009, 75:1570-1577. 10.1016/j.ijrobp.2009.05.035, 19880261.
9. Vassiliev O, Kry S, Kuban D, Salehpour M, Mohan R, Titt U. Treatment planning study of prostate cancer intensity modulated radiotherapy with a Varian Clinac operated without a flattening filter. Int J Radiat Oncol Biol Phys 2007, 68:1567-1571. 10.1016/j.ijrobp.2007.04.025, 17544596.
10. Poenisch F, Titt U, Vassiliev O, Kry SF, Mohan R. Properties of unflattened photon beams shaped by a multileaf collimator. Med Phys 2006, 33:1738-1746. 10.1118/1.2201149, 16872081.
11. Vassiliev ON, Kry SF, Chang JY, Balter PA, Titt U, Mohan R. Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac. J Appl Clin Med Phys 2009, 10:14-21.
12. Cashmore J, Ramtohul M, Ford D. Lowering whole body radiation doses in pediatric intensity modulated radiotherapy through the use of unflattened photon beams. Int J Radiat Oncol Biol Phys 2011, 80:1220-1227. 10.1016/j.ijrobp.2010.10.002, 21167659.
13. Georg D, Knöös T, McClean B. Current status and future perspective of flattening filter free photon beams. Med Phys 2011, 38:1280-1293. 10.1118/1.3554643, 21520840.
14. Kragl G, Wetterstedt AS, Knäusl B, Lind M, McCavana P, Knöös T, McClean B, Georg D. Dosimetric characteristics of 6 and 10 MV unflattened photon beams. Radiother Oncol 2009, 93:141-146. 10.1016/j.radonc.2009.06.008, 19592123.
15. Hrbacek J, Lang S, Kloeck S. Commissioning of photon beams of a flattening filter free linear accelerator and the accuracy of beam modeling using an anisotropic analytical algorithm. Int J Radiat Oncol Biol Phys 2011, 80:1228-1237. 10.1016/j.ijrobp.2010.09.050, 21129855.
16. Scorsetti M, Alongi F, Castiglioni S, Clivio A, Fogliata A, Lobefalo F, Mancosu P, Navarria P, Palumbo V, Pellegrini C, Pentimalli S, Reggiori G, Ascolese AM, Roggio A, Arcangeli S, Tozzi A, Vanetti E, Cozzi L. Feasibility and early clinical assessment of flattening filter free (FFF) based stereotactic body radiotherapy (SBRT) treatments. Radiat Oncol 2011, 6:113. 10.1186/1748-717X-6-113, 3179946, 21910868.
17. Jereczek-Fossa BA, Fariselli L, Beltramo G, Catalano G, Serafini F, Garibaldi C, Cambria R, Brait L, Possanzini M, Bianchi LC, Vavassori A, Zerini D, Orsi F, de Cobelli O, Orecchia R. Linac-based or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrent prostate cancer. Radiother Oncol 2009, 93:14-17. 10.1016/j.radonc.2009.04.001, 19409636.
18. Choi CW, Cho CK, Yoo SY, Kim MS, Yang KM, Yoo HJ, Seo YS, Kang JK, Lee DH, Lee KH, Lee ED, Rhu SY, Choi SC, Kim MH, Kim BJ. Image-guided stereotactic body radiation therapy in patients with isolated para-aortic lymph node metastases from uterine cervical and corpus cancer. Int J Radiat Oncol Biol Phys 2009, 74:147-153. 10.1016/j.ijrobp.2008.07.020, 18990511.
19. Kim MS, Yoo SY, Cho CK, Yoo HJ, Yang KM, Kang JK, Lee DH, Lee JI, Bang HY, Kim MS, Kang HJ. Stereotactic body radiotherapy for isolated para-aortic lymph node recurrence after curative resection in gastric cancer. J Korean Med Sci 2009, 24:488-492. 10.3346/jkms.2009.24.3.488, 2698197, 19543514.
20. Kim MS, Cho CK, Yang KM, Lee DH, Moon SM, Shin YJ. Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer. World J Gastroenterol 2009, 15:6091-6095. 10.3748/wjg.15.6091, 2797667, 20027683.
21. Reggiori G, Mancosu P, Castiglioni S, Alongi F, Pellegrini C, Lobefalo F, Catalano M, Fogliata A, Arcangeli S, Navarria P, Cozzi L, Scorsetti M. Can volumetric modulated arc therapy with flattening filter free beams play a role in stereotactic body radiotherapy for liver lesions? A volume-based analysis. Med Phys 2012, 39:1112-1118. 10.1118/1.3679858, 22320821.
22. Kragl G, Baier F, Lutz S, Albrich D, Dalaryd M, Kroupa B, Wiezorek T, Knöös T, Georg D. Flattening filter free beams in SBRT and IMRT: dosimetric assessment of peripheral doses. Z Med Phys 2011, 21:91-101.
23. Lohse I, Lang S, Hrbacek J, Scheidegger S, Bodis S, Macedo NS, Feng J, Lütolf UM, Zaugg K. Effect of high dose per pulse flattening filter-free beams on cancer cell survival. Radiother Oncol 2011, 101:226-232. 10.1016/j.radonc.2011.05.072, 21733592.
24. Wang JZ, Li XA, D'Souza WD, Stewart RD. Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys 2003, 57:543-552. 10.1016/S0360-3016(03)00499-1, 12957268.
25. Moiseenko V, Duzenli C, Durand RE. In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery. Med Phys 2007, 34:1514-1520. 10.1118/1.2712044, 17500482.