Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics

Magnetic Resonance in Medicine

Volumn 63, Issue 6, 2010, Pages 1493-1501

  Schär, Michael ^a,b   El Sharkawy, Abdel Monem M ^a   Weiss, Robert G ^a   Bottomley, Paul A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PHILIPS HEALTHCARE   (United States)

Author keywords

3 tesla; Creatine kinase; High energy phosphate; Human heart; Metabolism; Reaction rate; Saturation pulses; Saturation transfer

Indexed keywords

ENZYMES; HEART; METABOLISM; METABOLITES; MUSCLE; RATE CONSTANTS; REACTION RATES;

3 TESLA; CREATINE KINASE; HIGH ENERGY PHOSPHATES; HUMAN HEART; SATURATION TRANSFER;

SIGNAL TO NOISE RATIO;

CREATINE KINASE;

ADULT; ARTICLE; ENZYME KINETICS; FEMALE; GASTROCNEMIUS MUSCLE; HEART; HUMAN; HUMAN TISSUE; MAGNETIC FIELD; MALE; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SIGNAL NOISE RATIO; THORAX; TRIPLE REPETITION TIME SATURATION TRANSFER; CHEMISTRY; HEART MUSCLE; KINETICS; LEG; METABOLISM; MUSCLE;

CREATINE KINASE; HUMANS; KINETICS; LEG; MAGNETIC RESONANCE SPECTROSCOPY; MONTE CARLO METHOD; MUSCLES; MYOCARDIUM;

EID: 77952685206     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22347     Document Type: Article

References (33)

1. Forsen S, Hoffman RA. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J Chem Phys 1963;39:2892.
2. Bottomley PA, Hardy CJ. Mapping creatine-kinase reaction-rates in human brain and heart with 4-tesla saturation transfer P-31 NMR. J Magn Reson 1992;99:443-448.
3. Du F, Zhu XH, Qiao H, Zhang X, Chen W. Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain. Magn Reson Med 2007;57:103-114. (Pubitemid 46067941)
4. Bottomley PA, Ouwerkerk R, Lee RF, Weiss RG. Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med 2002;47:850-863.
5. Horska A, Fishbein KW, Fleg JL, Spencer RG. The relationship between creatine kinase kinetics and exercise intensity in human forearm is unchanged by age. Am J Physiol 2000;279:E333-339.
6. 31P NMR saturation transfer. Magn Reson Med 1989;9:39-52.
7. Goudemant JF, Francaux M, Mottet I, Demeure R, Sibomana M, Sturbois X. 31P NMR saturation transfer study of the creatine kinase reaction in human skeletal muscle at rest and during exercise. Magn Reson Med 1997;37:744-753. (Pubitemid 27187815)
8. Wiedermann D, Schneider J, Fromme A, Thorwesten L, Moller HE. Creatine loading and resting skeletal muscle phosphocreatine flux: a saturation-transfer NMR study. MAGMA 2001;13:118-126.
9. Weiss RG, Gerstenblith G, Bottomley PA. ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci U S A 2005;102:808-813. (Pubitemid 40282747)
10. Bottomley PA, Wu KC, Gerstenblith G, Schulman SP, Steinberg A, Weiss RG. Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study. Circulation 2009;119:1918-1924.
11. Smith CS, Bottomley PA, Schulman SP, Gerstenblith G, Weiss RG. Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation 2006;114:1151-1158. (Pubitemid 44386479)
12. Shivu GN, Abozguia K, Phan TT, Ahmed I, Henning A, Frenneaux M. (31)P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: experiences at 3 T. Eur J Radiol 2008 [doi:10.1016/j.ejrad.2008. 10.018].
13. Tyler DJ, Emmanuel Y, Cochlin LE, Hudsmith LE, Holloway CJ, Neubauer S, Clarke K, Robson MD. Reproducibility of (31)P cardiac magnetic resonance spectroscopy at 3 T. NMR Biomed 2008;22: 405-413.
14. Tyler DJ, Hudsmith LE, Clarke K, Neubauer S, Robson MD. A comparison of cardiac (31)P MRS at 1.5 and 3 T. NMR Biomed 2008;21: 793-798.
15. Baguet E, Roby C. Off-resonance irradiation effect in steady-state NMR saturation transfer. J Magn Reson 1997;128:149-160. (Pubitemid 127452798)
16. Gadian DG, Radda GK, Brown TR, Chance EM, Dawson MJ, Wilkie DR. The activity of creatine kinase in frog skeletal muscle studied by saturation-transfer nuclear magnetic resonance. Biochem J 1981;194: 215-228.
17. Horska A, Spencer GS. Correctly accounting for radiofrequency spill-over in saturation transfer experiments: application to measurement of the creatine kinase reaction rate in human forearm muscle. MAGMA 1997;5:159-163.
18. Bottomley PA, Ouwerkerk R. The dual-angle method for fast, sensitive T-1 measurement in-vivo with low-angle adiabatic pulses. J Magn Reson B 1994;104:159-167.
19. Garwood M, Ke Y. Symmetric pulses to induce arbitrary flip angles with compensation for RF inhomogeneity and resonance offsets. J Magn Reson Med 1991;94:511-525.
20. Bottomley PA, Ouwerkerk R. BIRP: an improved implementation of low-angle adiabatic (BIR-4) excitation pulses. J Magn Reson A 1993; 103:242-244.
21. El-Sharkawy AM, Schär M, Ouwerkerk R, Weiss RG, Bottomley PA. Quantitative cardiac (31)P spectroscopy at 3 tesla using adiabatic pulses. Magn Reson Med 2009;61:785-795.
22. Bodenhausen G, Freeman R, Morris GA. Simple pulse sequence for selective excitation in Fourier-transform NMR. J Magn Reson 1976; 23:171-175.
23. Fischer SE, Wickline SA, Lorenz CH. Novel real-time R-wave detection algorithm based on the vectorcardiogram for accurate gated magnetic resonance acquisitions. Magn Reson Med 1999;42:361-370.
24. Eberhardt KW, Schär M, Barmet C, Tsao J, Boesiger P, Kozerke S. Linear response equilibrium. J Magn Reson 2006;178:142-154.
25. 31P- metabolites in human calf muscle at 3 T. Magn Reson Med 2003;49: 620-625.
26. Schär M, Kozerke S, Fischer SE, Boesiger P. Cardiac SSFP imaging at 3 tesla. Magn Reson Med 2004;51:799-806.
27. Gabr RE, Weiss RG, Bottomley PA. Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson 2008;191:248-258.
28. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996;93:1043-1065.
29. Xiong Q, Li Q, Mansoor A, Jameel MN, Du F, Chen W, Zhang J. Novel strategy for measuring creatine kinase reaction rate in the in vivo heart. Am J Physiol Heart Circ Physiol 2009;297:H1010-1019.
30. Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI. Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest 2001;108:733-737. (Pubitemid 32906202)
31. 31P magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 2003;100: 14409-14414.
32. 31P spectroscopy using the magnetization transfer experiment. NMR Biomed 2008;21:437-443.
33. Ugurbil K, Petein M, Maidan R, Michurski S, From AH. Measurement of an individual rate constant in the presence of multiple exchanges: application to myocardial creatine kinase reaction. Biochemistry 1986;25:100-107. (Pubitemid 16053085)