P16INKa immunocytochemistry in fine-needle aspiration cytology smears of metastatic head and neck squamous cell carcinoma

Acta Cytologica

Volumn 57, Issue 1, 2013, Pages 33-37

  Grimes, Reni ^a   Garcia Buitrago, Monica T ^b   Jorda, Merce ^b   Ganjei Azar, Parvin ^b   Ferrell, Annapoorna ^c   Gomez Fernandez, Carmen ^b  

^a Radiology Imaging Associates of Daytona Beach   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

Fine needle aspiration; Head and neck carcinoma; Immunocytochemistry; p16INKa; Squamous cell carcinoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN ANTIBODY; PROTEIN P16;

ADULT; AGED; ARTICLE; ASPIRATION CYTOLOGY; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NECK METASTASIS; OROPHARYNX; OROPHARYNX CARCINOMA; PAPANICOLAOU TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; TUMOR LOCALIZATION; FINE NEEDLE ASPIRATION BIOPSY; IMMUNOHISTOCHEMISTRY; METASTASIS; PRIMARY TUMOR;

HUMAN PAPILLOMAVIRUS;

EID: 84870353050     PISSN: 00015547     EISSN: 19382650     Source Type: Journal    
DOI: 10.1159/000342501     Document Type: Article

References (12)

1. Begum S, Gillison ML, Ansari-Lari MA, Shah K, Westra WH: Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin. Clin Cancer Res 2003; 9: 6469-6475.
2. Begum S, Gillison ML, Nicol TL, Westra WH: Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2007; 13: 1186-1191.
3. Nieder C, Gregoire V, Kian Ang K: Cervical lymph node metastases from occult squamous cell carcinoma: cut down a tree to get an apple? Head and Neck 2001; 50: 727-733.
4. De Braud F, Heilbrun LK, Ahmed K, Sakr W, Ensley JF, Kish JA, Tapazoglou E, Al-Sarraf M: Metastatic squamous cell carcinoma of an unknown primary localized to the neck. Advantages of an aggressive treatment. Cancer 1989; 64: 510-515.
5. Hennessey PT, Westra WH, Califano JA: Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. J Dent Res 2009; 88: 300-306.
6. Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Sasaki C, Rimm DL, Psyrri A: Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin Cancer Res 2004; 10: 5684-5691.
7. Singhi AD, Westra WH: Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer 2010; 116: 2166-2173.
8. Smeets SJ, Hesselink AT, Speel EM, Haesevoets A, Snijders PJF, Pawlita M, Meijer CJLM, Braakhuis BJM, René Leemans C, Brakenhoff RH: A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 2007; 121: 2465-2472.
9. Fakhry C, Gillison ML: Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol 2006; 24: 2606-2611.
10. Lee WT, Tubbs RR, Teker Scharpf J, Strome M, Wood B, Lorenz RR, Hunt J: Use of in situ hibridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol and tobacco use. Arch Pathol/Lab Med 2008; 132: 1653-1656.
11. Zhang MQ, El-Mofty SK, Davila RM: Detection of human papillomavirus- related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis a tool for identifying the site of an occult head and neck primary. Cancer Cytopathol 2008; 114: 118-123.
12. Ganjei-Azar P, Nadji M: Color Atlas of Immunocytochemistry in Diagnostic Cytology. New York, Springer, 2006, pp 3-8.