Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 3719-3730

  Vaněček, Václav ^a,e   Zablotskii, Vitalii ^b   Forostyak, Serhiy ^a,e   Růžička, Jiří ^a   Herynek, Vít ^c   Babič, Michal ^d   Jendelová, Pavla ^a,e   Kubinová, Šárka ^a   Dejneka, Alexandr ^b   Syková, Eva ^a,e  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b INSTITUTE OF PHYSICS   (Czech Republic)

^c INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^d INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^e CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Magnetism; Mesenchymal stem cell; Modeling; Nanoparticle; Spinal cord injury

Indexed keywords

SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMAGNETISM; CELL KINETICS; CELL LABELING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HISTOLOGY; IMAGE ANALYSIS; IN VIVO STUDY; MAGNETIC FIELD; MAGNETOTHERAPY; MATHEMATICAL MODEL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCESS OPTIMIZATION; RAT; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; THERAPY EFFECT;

ANIMALS; HISTOCYTOCHEMISTRY; INJECTIONS, SPINAL; MAGNETITE NANOPARTICLES; MAGNETS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MODELS, THEORETICAL; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES;

RATTUS;

EID: 84870351769     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S32824     Document Type: Article

References (47)

1. Kubinova S, Sykova E. Biomaterials combined with cell therapy for treatment of spinal cord injury. Regen Med. 2012;7(2):207-224.
2. Talac R, Friedman JA, Moore MJ, etal. Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies. Biomaterials. 2004;25(9):1505-1510.
3. Sykova E, Homola A, Mazanec R, etal. Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant. 2006;15(8-9):675-687.
4. Arboleda D, Forostyak S, Jendelova P, etal. Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury. Cell Mol Neurobiol. 2011;31(7):1113-1122.
5. Kim J, Kim IS, Cho TH, etal. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials. 2007;28(10):1830-1837.
6. Fan H, Hu Y, Zhang C, etal. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials. 2006;27(26):4573-4580.
7. Gaebel R, Ma N, Liu J, etal. Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration. Biomaterials. 2011; 32(35):9218-9230.
8. Borlongan CV, Glover LE, Tajiri N, Kaneko Y, Freeman TB. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Prog Neurobiol. 2011;95(2):213-228.
9. Forostyak S, Jendelova P, Kapcalova M, Arboleda D, Sykova E. Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. Cytotherapy. 2011;13(9):1036-1046.
10. Kubinova S, Sykova E. Nanotechnology for treatment of stroke and spinal cord injury. Nanomedicine (Lond). 2010;5(1):99-108.
11. Urdzikova L, Jendelova P, Glogarova K, Burian M, Hajek M, Sykova E. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J Neurotrauma. 2006;23(9):1379-1391.
12. Osaka M, Honmou O, Murakami T, etal. Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome. Brain Res. 2010;1343: 226-235.
13. Chopp M, Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 2002;1(2):92-100.
14. Akiyama Y, Radtke C, Honmou O, Kocsis JD. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia. 2002;39(3):229-236.
15. Chen X, Katakowski M, Li Y, etal. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res. 2002;69(5):687-691.
16. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 15 2005;105(4):1815-1822.
17. Crigler L, Robey RC, Asawachaicharn A, Gaupp D, Phinney DG. Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol. 2006;198(1):54-64.
18. Wilkins A, Kemp K, Ginty M, Hares K, Mallam E, Scolding N. Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Res. 2009;3:63-70.
19. Paul C, Samdani AF, Betz RR, Fischer I, Neuhuber B. Grafting of human bone marrow stromal cells into spinal cord injury: a comparison of delivery methods. Spine (Phila Pa 1976). 2009:328-334.
20. Jendelova P, Herynek V, Urdzikova L, etal. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res. 2004;76(2):232-243.
21. Sykova E, Jendelova P. Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann N Y Acad Sci. 2005;1049:146-160.
22. Huang Z, Pei N, Wang Y, etal. Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics. Biomaterials. 2010; 31(8):2130-2140.
23. Wilhelm C, Bal L, Smirnov P, etal. Magnetic control of vascular network formation with magnetically labeled endothelial progenitor cells. Biomaterials. 2007;28(26):3797-3806.
24. Arbab AS, Jordan EK, Wilson LB, Yocum GT, Lewis BK, Frank JA. In vivo trafficking and targeted delivery of magnetically labeled stem cells. Hum Gene Ther. 2004;15(4):351-360.
25. Song M, Kim YJ, Kim YH, Roh J, Kim SU, Yoon BW. Using a neodymium magnet to target delivery of ferumoxide-labeled human neural stem cells in a rat model of focal cerebral ischemia. Hum Gene Ther. 2010;21(5):603-610.
26. Nishida K, Tanaka N, Nakanishi K, etal. Magnetic targeting of bone marrow stromal cells into spinal cord: through cerebrospinal fluid. Neuroreport. 21 2006;17(12):1269-1272.
27. Dominici M, Le Blanc K, Mueller I, etal. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315-317.
28. Babic M, Horak D, Trchova M, etal. Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling. Bioconjug Chem. 2008;19(3): 740-750.
29. De la Calle JL, Paino CL. A procedure for direct lumbar puncture in rats. Brain Res Bull. 2002;59(3):245-250.
30. Mothe AJ, Tator CH. Transplanted neural stem/progenitor cells generate myelinating oligodendrocytes and Schwann cells in spinal cord demyelination and dysmyelination. Exp Neurol. 2008;213(1): 176-190.
31. Zablotskii V, Pastor JM, Larumbe S, etal. High-field gradient permanent micromagnets for targeted drug delivery with magnetic nanoparticles. AIP Conf. Proc. 2010;1311:152-157.
32. Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys. 2003; 36(13):R167-R181.
33. Zablotskii V, Lunov O, Dejneka A, etal. Nanomechanics of magnetically driven cellular endocytosis. Appl Phys Lett. 2011;99(18): 183701-183703.
34. Mothe AJ, Bozkurt G, Catapano J, etal. Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat. Spinal Cord. 2011;49(9):967-973.
35. Horak D, Babic M, Jendelova P, etal. Effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling. J Magn Magn Mater. 2009;321(10):1539-1547.
36. Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marban E. Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res. 2010; 106(10):1570-1581.
37. Schafer R, Bantleon R, Kehlbach R, etal. Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles. BMC Cell Biol. 2010;11:22.
38. Sykova E, Jendelova P, Urdzikova L, Lesny P, Hejcl A. Bone marrow stem cells and polymer hydrogels-two strategies for spinal cord injury repair. Cell Mol Neurobiol. 2006;26(7-8):1113-1129.
39. Bakshi A, Hunter C, Swanger S, Lepore A, Fischer I. Minimally invasive delivery of stem cells for spinal cord injury: advantages of the lumbar puncture technique. J Neurosurg Spine. 2004;1(3):330-337.
40. Satake K, Lou J, Lenke LG. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine (Phila Pa 1976). 2004;29(18):1971-1979.
41. Pardridge WM. Drug transport in brain via the cerebrospinal fluid. Fluids Barriers CNS. 2011;8:7.
42. Di Chiro G. Observations on the circulation of the cerebrospinal fluid. Acta Radiol Diagn (Stockh). 1966;5:988-1002.
43. Greitz D, Hannerz J. A proposed model of cerebrospinal fluid circulation: observations with radionuclide cisternography. AJNR Am J Neuroradiol. 1996;17(3):431-438.
44. Linninger AA, Xenos M, Sweetman B, Ponkshe S, Guo X, Penn R. A mathematical model of blood, cerebrospinal fluid and brain dynamics. J Math Biol. 2009;59(6):729-759.
45. Sasaki H, Tanaka N, Nakanishi K, etal. Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model. Spine (Phila Pa 1976). 2011;36(12):933-938.
46. Häfeli UO, Gilmour K, Zhou A, Lee S, Hayden ME. Modeling of magnetic bandages for drug targeting: Button vs Halbach arrays. J Magn Magn Mater. 2007;311(1):323-329.
47. Novotna B, Jendelova P, Kapcalova M, etal. Oxidative damage to biological macromolecules in human bone marrow mesenchymal stromal cells labeled with various types of iron oxide nanoparticles. Toxicol Lett. 2012;210(1):53-63.