Proteomic analysis of midtrimester amniotic fluid to identify novel biomarkers for preterm delivery

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 12, 2012, Pages 2488-2493

  Fotopoulou, Christina ^a   Kyeyamwa, Sarah ^a   Linder, Mattea ^b   Thieme, Daniela ^b   Hartenstein, Sebastian ^a   Klein, Oliver ^b   Dudenhausen, Joachim W ^b   Henrich, Wolfgang ^b   Kalache, Karim D ^b   Bamberg, Christian ^b  

^a Department of Gynecology ^*  (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Amniotic fluid; Proteomics; SELDI TOF; Subclinical inflammation

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 2; BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; CALGRANULIN A; CALGRANULIN B; CALGRANULIN C; INTERLEUKIN 6; SOMATOMEDIN BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; AFFINITY CHROMATOGRAPHY; AMNIOCENTESIS; AMNION FLUID ANALYSIS; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; ION EXCHANGE CHROMATOGRAPHY; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; SECOND TRIMESTER PREGNANCY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; VAGINAL DELIVERY;

ADULT; AMNIOCENTESIS; AMNIOTIC FLUID; BIOLOGICAL MARKERS; DELIVERY, OBSTETRIC; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PREMATURE BIRTH; PROGNOSIS; PROTEOME; PROTEOMICS; RISK FACTORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84870348702     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2012.712565     Document Type: Article

References (53)

1. Mathews TJ, Menacker F, MacDorman MF. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep 2004;53:1-29.
2. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Munson ML. Births: final data for 2003. Natl Vital Stat Rep 2005;54:1-116.
3. Oh KJ, Lee SE, Jung H, Kim G, Romero R, Yoon BH. Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency. J Perinat Med 2010;38:261-268.
4. Vaisbuch E, Romero R, Gomez R, Kusanovic JP, Mazaki-Tovi S, Chaiworapongsa T, Hassan SS. An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2011;24:391-396.
5. Lee SE, Romero R, Park CW, Jun JK, Yoon BH. The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency. Am J Obstet Gynecol 2008;198:633.e1-633.e8.
6. Romero R, Chaiworapongsa T, Savasan ZA, Hussein Y, Dong Z, Kusanovic JP, Kim CJ, Hassan SS. Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE. J Matern Fetal Neonatal Med 2012;25:558-567.
7. Romero R, Quintero R, Oyarzun E, Wu YK, Sabo V, Mazor M, Hobbins JC. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol 1988;159:661-666.
8. Gomez R, Romero R, Nien JK, Medina L, Carstens M, Kim YM, Chaiworapongsa T, et al. Idiopathic vaginal bleeding during pregnancy as the only clinical manifestation of intrauterine infection. J Matern Fetal Neonatal Med 2005;18:31-37. (Pubitemid 41224360)
9. Gomez R, Romero R, Nien JK, Chaiworapongsa T, Medina L, Kim YM, Yoon BH, et al. A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2005;192:678-689. (Pubitemid 40311256)
10. Hassan S, Romero R, Hendler I, Gomez R, Khalek N, Espinoza J, Nien JK, et al. A sonographic short cervix as the only clinical manifestation of intra-amniotic infection. J Perinat Med 2006;34:13-19. (Pubitemid 43106293)
11. Kim SM, Romero R, Lee J, Mi Lee S, Park CW, Shin Park J, Yoon BH. The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria for preterm labor need to be changed? J Matern Fetal Neonatal Med 2012.
12. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M. The preterm parturition syndrome. BJOG 2006;113 Suppl 3:17-42. (Pubitemid 44934664)
13. Greci LS, Gilson GJ, Nevils B, Izquierdo LA, Qualls CR, Curet LB. Is amniotic fluid analysis the key to preterm labor? A model using interleukin-6 for predicting rapid delivery. Am J Obstet Gynecol 1998;179:172-178. (Pubitemid 28394492)
14. Heikkinen J, Mottonen M, Pulkki K, Lassila O, Alanen A. Cytokine levels in midtrimester amniotic fluid in normal pregnancy and in the prediction of pre-eclampsia. Scand J Immunol 2001;53:310-314. (Pubitemid 32193699)
15. Yoon BH, Oh SY, Romero R, Shim SS, Han SY, Park JS, Jun JK. An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol 2001;185:1162-1167. (Pubitemid 33097381)
16. Cho CK, Shan SJ, Winsor EJ, Diamandis EP. Proteomics analysis of human amniotic fluid. Mol Cell Proteomics 2007;6:1406-1415. (Pubitemid 47365438)
17. Ghezzi F, Franchi M, Raio L, Di Naro E, Bossi G, D'Eril GV, Bolis P. Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. Am J Obstet Gynecol 2002;186:268-273. (Pubitemid 34165445)
18. Ghidini A, Jenkins CB, Spong CY, Pezzullo JC, Salafia CM, Eglinton GS. Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with greater risk of subsequent preterm delivery. Am J Reprod Immunol 1997;37:227-231. (Pubitemid 27149783)
19. Nien JK, Yoon BH, Espinoza J, Kusanovic JP, Erez O, Soto E, Richani K, et al. A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery. Am J Obstet Gynecol 2006;195:1025-1030. (Pubitemid 44415671)
20. Wenstrom KD, Andrews WW, Tamura T, DuBard MB, Johnston KE, Hemstreet GP. Elevated amniotic fluid interleukin-6 levels at genetic amniocentesis predict subsequent pregnancy loss. Am J Obstet Gynecol 1996;175:830-833. (Pubitemid 26357937)
21. Chaiworapongsa T, Romero R, Tolosa JE, Yoshimatsu J, Espinoza J, Kim YM, Kim JC, et al. Elevated monocyte chemotactic protein-1 in amniotic fluid is a risk factor for pregnancy loss. J Matern Fetal Neonatal Med 2002;12:159-164.
22. Michaels JE, Dasari S, Pereira L, Reddy AP, Lapidus JA, Lu X, Jacob T, et al. Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes. J Proteome Res 2007;6:1277-1285. (Pubitemid 46724024)
23. Queloz PA, Crettaz D, Thadikkaran L, Sapin V, Gallot D, Jani J, Deprest J, et al. Proteomic analyses of amniotic fluid: potential applications in health and diseases. J Chromatogr B Analyt Technol Biomed Life Sci 2007;850:336-342. (Pubitemid 46618180)
24. Romero R, Espinoza J, Rogers WT, Moser A, Nien JK, Kusanovic JP, Gotsch F, et al. Proteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: the use of a novel computational method to analyze mass spectrometric profiling. J Matern Fetal Neonatal Med 2008;21:367-388. (Pubitemid 351999170)
25. Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, Moser A, et al. Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med 2010;23:261-280.
26. Tsangaris GT, Kolialexi A, Karamessinis PM, Anagnostopoulos AK, Antsaklis A, Fountoulakis M, Mavrou A. The normal human amniotic fluid supernatant proteome. In Vivo 2006;20:479-490. (Pubitemid 44184104)
27. Gravett MG, Novy MJ, Rosenfeld RG, Reddy AP, Jacob T, Turner M, McCormack A, et al. Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers. JAMA 2004;292:462-469. (Pubitemid 38988955)
28. Buhimschi IA, Christner R, Buhimschi CS. Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation. BJOG 2005;112:173-181. (Pubitemid 40188245)
29. Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, et al. Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Med 2007;4:e18.
30. Bujold E, Romero R, Kusanovic JP, Erez O, Gotsch F, Chaiworapongsa T, Gomez R, et al. Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry. J Matern Fetal Neonatal Med 2008;21:697-713.
31. Ruetschi U, Rosen A, Karlsson G, Zetterberg H, Rymo L, Hagberg H, Jacobsson B. Proteomic analysis using protein chips to detect biomarkers in cervical and amniotic fluid in women with intra-amniotic inflammation. J Proteome Res 2005;4:2236-2242. (Pubitemid 41814292)
32. Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 1990;87:210-214.
33. Hitti J, Lapidus JA, Lu X, Reddy AP, Jacob T, Dasari S, Eschenbach DA, et al. Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid. Am J Obstet Gynecol 2010;203:32.e1-32.e8.
34. Lee SE, Han BD, Park IS, Romero R, Yoon BH. Evidence supporting proteolytic cleavage of insulin-like growth factor binding protein-1 (IGFBP-1) protein in amniotic fluid. J Perinat Med 2008;36:316-323. (Pubitemid 351948609)
35. Lee J, Lee SM, Oh KJ, Park CW, Jun JK, Yoon BH. Fragmented forms of insulin-like growth factor binding protein-1 in amniotic fluid of patients with preterm labor and intact membranes. Reprod Sci 2011;18:842-849.
36. Tsangaris G, Weitzdorfer R, Pollak D, Lubec G, Fountoulakis M. The amniotic fluid cell proteome. Electrophoresis 2005;26:1168-1173. (Pubitemid 40514808)
37. Buhimschi CS, Weiner CP, Buhimschi IA. Proteomics, part II: the emerging role of proteomics over genomics in spontaneous preterm labor/birth. Obstet Gynecol Surv 2006;61:543-553. (Pubitemid 44125760)
38. Wenstrom KD, Andrews WW, Hauth JC, Goldenberg RL, DuBard MB, Cliver SP. Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol 1998;178:546-550. (Pubitemid 28207508)
39. Gomez R, Galasso M, Romero R, Mazor M, Sorokin Y, Goncalves L, Treadwell M. Ultrasonographic examination of the uterine cervix is better than cervical digital examination as a predictor of the likelihood of premature delivery in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1994;171:956-964. (Pubitemid 24341477)
40. Goepfert AR, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A, Thom E, et al. The preterm prediction study: quantitative fetal fibronectin values and the prediction of spontaneous preterm birth. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 2000;183:1480-1483.
41. Goncalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3-13. (Pubitemid 34754487)
42. Dammann O, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000;12:99-104. (Pubitemid 30165567)
43. Davis NM, Ford GW, Anderson PJ, Doyle LW; Victorian Infant Collaborative Study Group. Developmental coordination disorder at 8 years of age in a regional cohort of extremely-low-birthweight or very preterm infants. Dev Med Child Neurol 2007;49:325-330. (Pubitemid 46730682)
44. Maalouf EF, Duggan PJ, Rutherford MA, Counsell SJ, Fletcher AM, Battin M, Cowan F, Edwards AD. Magnetic resonance imaging of the brain in a cohort of extremely preterm infants. J Pediatr 1999;135:351-357. (Pubitemid 30180510)
45. Gomez R, Ghezzi F, Romero R, Yoon BH, Mazor M, Berry SM. Two thirds of human fetuses with microbial invasion of the amnion cavity have a detectable systematic cytokine response before birth. Am J Obstet Gynecol 1997;176:514.
46. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202. (Pubitemid 28394495)
47. Bamberg C, Fotopoulou C, Linder M, Roehr CC, Dudenhausen JW, Henrich W, Kalache K. Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-a, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender. J Perinat Med 2011;39:403-409.
48. Bamberg C, Fotopoulou C, Thiem D, Roehr CC, Dudenhausen JW, Kalache KD. Correlation of midtrimester amniotic fluid cytokine concentrations with adverse pregnancy outcome in terms of spontaneous abortion, preterm birth, and preeclampsia. J Matern Fetal Neonatal Med 2012;25:812-817.
49. Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M, Vijayaraghavan J, et al.; PREGNANT Trial. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2011;38:18-31.
50. Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O'Brien JM, Cetingoz E, Da Fonseca E, et al. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol 2012;206:124.e1-124.19.
51. Wang B, Navath RS, Romero R, Kannan S, Kannan R. Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells. Int J Pharm 2009;377:159-168.
52. Wang X, Svedin P, Nie C, Lapatto R, Zhu C, Gustavsson M, Sandberg M, et al. N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxicischemic brain injury. Ann Neurol 2007;61:263-271. (Pubitemid 46557350)
53. Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Janisse J, Romero R, Kannan RM. Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Sci Transl Med 2012;4:130ra46.