Development of a nanoporous and multilayer drug-delivery platform for medical implants

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 5327-5338

  Karagkiozaki, Varvara ^a   Vavoulidis, Eleftherios ^a   Karagiannidis, Panagiotis G ^a   Gioti, Maria ^a   Fatouros, Dimitrios G ^a   Vizirianakis, Ioannis S ^a   Logothetidis, Stergios ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Atomic force microscopy; Drug delivery; Implants; Polymers; Spin coating; Stents

Indexed keywords

DIPYRIDAMOLE; MOLECULAR LAYER; POLYCAPROLACTONE; POLYGLACTIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIODEGRADABLE IMPLANT; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG ELUTING STENT; DRUG RELEASE; ELLIPSOMETRY; HUMAN; HUMAN CELL; NANOPORE; PHASE SEPARATION; POROSITY; STRUCTURE ANALYSIS; THICKNESS; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

BIOCOMPATIBLE MATERIALS; BLOOD PLATELETS; CELLS, CULTURED; CRYSTALLIZATION; DIPYRIDAMOLE; DRUG-ELUTING STENTS; HUMANS; LACTIC ACID; NANOCAPSULES; PARTICLE SIZE; PLATELET ADHESIVENESS; PLATELET AGGREGATION INHIBITORS; POLYESTERS; POLYGLYCOLIC ACID; POROSITY; PROSTHESIS DESIGN; TREATMENT OUTCOME;

EID: 84870347197     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S31185     Document Type: Article

References (29)

1. Kang H, Kim DJ, Park S, Yoo J, Ryu YS. Controlled drug release using nanoporous anodic aluminum oxide on stent. Thin Solid Films. 2007;515:5184-5187.
2. Orosz KE, Gupta S, Hassink M, etal. Delivery of antiangiogenic and antioxidant drugs of ophthalmic interest through a nanoporous inorganic filter. Mol Vis. 2004;10:555-565.
3. Losic D, Velleman L, Kant K, etal. Self-ordering electrochemistry: a simple approach for engineering nanopore and nanotube arrays for emerging applications. Aust J Chem. 2011;64:294-301.
4. Aninwene GE II, Yao C, Webster TJ. Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces. Int J Nanomedicine. 2008;3:257-264.
5. Nuxoll EE, Hillmyer MA, Wang R, Leighton C, Siegel RA. Composite block polymer-microfabricated silicon nanoporous membrane. ACS Appl Mater Interfaces. 2009;1:888-893.
6. Bielecka U, Lutsyk P, Janus K, Sworakowski J, Bartkowiak W. Effect of solution aging on morphology and electrical characteristics of regioregular P3HT FETs fabricated by spin-coating and spray coating. Org Electr. 2011;12:1768-1776.
7. Mansour H, Sohn M, Ghananeem A, DeLuca. P. Materials for pharmaceutical dosage forms: molecular pharmaceutics and controlled release drug delivery aspects. Int J Mol Sci. 2010;11:3298-3322.
8. Hara H, Nakamura M, Palmaz JC, Schwartz RS. Role of stent design and coatings on restenosis and thrombosis. Adv Drug Deliv Rev. 2006;58: 377-386.
9. Karagiannidis P, Kassavetis S, Pitsalidis C, Logothetidis S. Thermal annealing effect on the nanomechanical properties and structure of P3HT:PCBM thin films. Thin Solid Films. 2011;519:4105-4109.
10. Souza F, Lopes K, Nascente P, Leite E. Nanostructured hematite thin films produced by spin-coating deposition solution: Application in water splitting. Solar Energy Mater and Solar Cells. 2009;93:362-368.
11. Acharya G, Park K. Mechanisms of controlled drug release from drug-eluting stents. Adv Drug Deliv Rev. 2006;58:387-340.
12. Garg S, Serruys P. Coronary stents: current status. J Am Coll Cardiol. 2010;56:1-42.
13. Mammen EF. An overview of dipyridamole. Thrombosis Res. 1990;57:1-3.
14. Müller D, Anderson K. Biomolecular imaging using atomic force microscopy. Trends in Biotech. 2002;20:545-549.
15. Azzam RMA, Boshara N. Ellipsometry and polarized light. In: Azzam RMA, editor. Ellipsometry and Polarized Light. North Holland: Amsterdam; 1977 San Diego.
16. Jellison GE, Modine FA. Parameterization of the optical functions of amorphous materials in the interband region. Appl. Phys. Lett. 1996; 69(3):371-373.
17. Hartwig JH. Platelet structure. In: Michelson AD, editor. Platelets. Academic Press; San Diego 2002:37-45.
18. Karagkiozaki V, Logothetidis S, Kalfagiannis N, etal. AFM probing platelets activation behavior on titanium nitride nanocoatings for biomedical applications. J Nanomedicine. 2009;5:64-72.
19. Bavry A, Kumbhani D, Helton T, Borek P, Mood G, Bhatt D. Late thrombosis of drug-eluting stents: a meta-analysis of randomized clinical trials. Am J Med. 2006;119:1056-1061.
20. Liistro F, Colombo A. Late acute thrombosis after paclitaxel eluting stent implantation. Heart. 2001;86:262-264.
21. Armentano I, Dottori M, Fortunati E, Mattioli S, Kenny JM. Biodegradable polymer matrix nanocomposites for tissue engineering: a review. Polym Degrad Stab. 2010;95:2126-2146.
22. Lu L, Garcia CA, Mikos AG. In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. J Biomed Mater Res. 1999;46:236-244.
23. Gultepe E, Nagesha D, Sridhar S, Amiji M. Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices. Adv Drug Deliv Rev. 2010;62:305-315.
24. Norman J, Desal T. Methods for fabrication of nanoscale topography for tissue engineering scaffolds. Ann Biomed Eng. 2006;34(1):89-101.
25. Affrossman S, Henn G, O'Neill S, Pethrick P, Stamm M. Surface topography and composition of deuterated polystyrene-poly (bromostyrene) blends. Macromolecules 1996;29:5010-5016.
26. Hughes G. Nanostructure-mediated drug delivery. J Nanomedicine. 2005;1:22-30.
27. Karagkiozaki V, Logothetidis S, Lousinian S, Giannoglou G. Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications. Int J Nanomedicine. 2008;3:461-469.
28. Karagkiozaki V, Logothetidis S, Laskarakis A, Giannoglou G, Lousinian S. AFM Study of the thrombogenicity of carbon-based coatings for cardiovascular applications. Mater Sci Eng B. 2008;152:16-21.
29. Karagkiozaki V, Logothetidis S, Kassavetis S, Giannoglou G. Nanomedicine for the reduction of the thrombogenicity of stent coatings. Int J Nanomedicine. 2010;5:239-248.