Characterization of drug-release kinetics in trabecular bone from titania nanotube implants

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 4883-4892

  Aw, Moom Sinn ^a   Khalid, Kamarul A ^a,b   Gulati, Karan ^a   Atkins, Gerald J ^a   Pivonka, Peter ^c   Findlay, David M ^a   Losic, Dusan ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b INTERNATIONAL ISLAMIC UNIVERSITY MALAYSIA   (Malaysia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Drug diffusion; Drug releasing implant; Local drug delivery; Zetos bone bioreactor

Indexed keywords

NANOTUBE; TITANIUM DIOXIDE;

ARTICLE; BONE IMPLANT; BONE STRUCTURE; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG TRANSPORT; FLUORESCENCE SPECTROSCOPY; HYDROPHILICITY; MAGNETIC FIELD; NANOENGINEERING; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; TRABECULAR BONE;

ANIMALS; CATTLE; KINETICS; MALE; MATERIALS TESTING; NANOCAPSULES; NANOTUBES; PARTICLE SIZE; RHODAMINES; STERNUM; TITANIUM;

BOVINAE;

EID: 84870338819     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S33655     Document Type: Article

References (40)

1. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science. 2000;289(5484):1508-1514.
2. Mainardes RM, Silva LP. Drug delivery systems: past, present, and future. Curr Drug Targets. 2004;5(5):449-455.
3. LaVan DA, McGuire T, Langer R. Small-scale systems for in vivo drug delivery. Nat Biotechnol. 2003;21(10):1184-1191.
4. Jain AK, Panchagnula R. Skeletal drug delivery systems. Int J Pharm. 2000;206(1-2):1-12.
5. Porter JR, Ruckh TT, Popat KC. Bone tissue engineering: a review in bone biomimetics and drug delivery strategies. Biotechnol Prog. 2009; 25(6):1539-1560.
6. Wu P, Grainger DW. Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials. 2006;27(11):2450-2467.
7. Buchholz HW, Elson RA, Engelbrecht E, Lodenkämper H, Röttger J, Siegel A. Management of deep infection of total hip replacement. J Bone Joint Surg Br. 1981;63-B(3):342-353.
8. Soundrapandian C, Sa B, Datta S. Organic-inorganic composites for bone drug delivery. AAPS Pharm Sci Tech. 2009;10(4):1158-1171.
9. Simchi A, Tamjid E, Pishbin F, Boccaccini AR. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomedicine. 2011;7(1):22-39.
10. Zhao L, Chu PK, Zhang Y, Wu Z. Antibacterial coatings on titanium implants. J Biomed Mater Res B Appl Biomater. 2009;91(1):470-480.
11. Tran PA, Sarin L, Hurt RH, Webster TJ. Opportunities for nanotechnology-enabled bioactive bone implants. J Mater Chem. 2009;19:2653-2659.
12. Zilberman M, Elsner JJ. Antibiotic-eluting medical devices for various applications. J Control Release. 2008;130(3):202-215.
13. Lewis G. Alternative acrylic bone cement formulations for cemented arthroplasties: present status, key issues, and future prospects. J Biomed Mater Res B Appl Biomater. 2008;84(2):301-319.
14. Arcos D, López-Noriega A, Ruiz-Hernández E, Terasaki O, Vallet-Regí M. Ordered mesoporous microspheres for bone grafting and drug delivery. Chem Mater. 2009;21(6):1000-1009.
15. Hoppe A, Güldal NS, Boccaccini AR. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. 2011;32(11):2757-2774.
16. Liu H, Webster TJ. Nanomedicine for implants: a review of studies and necessary experimental tools. Biomaterials. 2007;28(2):354-369.
17. Ghicov A, Schmuki P. Self-ordering electrochemistry: a review on growth and functionality of TiO(2) nanotubes and other self-aligned MO(x) structures. Chem Commun (Camb). 2009;(20):2791-2808.
18. Losic D, Simovic S. Self-ordered nanopore and nanotube platforms for drug delivery applications. Expert Opin Drug Deliv. 2009;6(12): 1363-1381.
19. Roy P, Berger S, Schmuki P. TiO(2) nanotubes: synthesis and applications. Angew Chem Int Ed Engl. 2011;50(13):2904-2939.
20. Popat KC, Eltgroth M, LaTempa TJ, Grimes CA, Desai TA. Titania nanotubes: a novel platform for drug-eluting coatings for medical implants? Small. 2007;3(11):1878-1881.
21. Rani S, Roy SC, Paulose M, etal. Synthesis and applications of electrochemically self-assembled titania nanotube arrays. Phys Chem Chem Phys. 2010;12(12):2780-2800.
22. Sikavitsas VI, Temenoff JS, Mikos AG. Biomaterials and bone mechanotransduction. Biomaterials. 2001;22(19):2581-2593.
23. Davies CM, Jones DB, Stoddart MJ, etal. Mechanically loaded ex vivo bone culture system 'Zetos': systems and culture preparation. Eur Cell Mater. 2006;11:57-75.
24. David V, Guignandon A, Martin A, etal. Ex vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A. 2008;14(1): 117-126.
25. Endres S, Kratz M, Wunsch S, Jones DB. Zetos: a culture loading system for trabecular bone. Investigation of different loading signal intensities on bovine bone cylinders. J Musculoskelet Neuronal Interact. 2009;9(3): 173-183.
26. David V, Martin A, Lafage-Proust MH, etal. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. 2007;148(5):2553-2562.
27. Gulati K, Ramakrishnan S, Aw MS, Atkins GJ, Findlay DM, Losic D. Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion. Acta Biomater. 2012;8(1): 449-456.
28. Simovic S, Losic D, Vasilev K. Controlled drug release from porous materials by plasma polymer deposition. Chem Commun (Camb). 2010; 46(8):1317-1319.
29. Aw MS, Addai-Mensah J, Losic D. A multi-drug delivery system with sequential release using titania nanotube arrays. Chem Commun (Camb). 2012;48(27):3348-3350.
30. Aw MS, Simovic S, Addai-Mensah J, Losic D. Polymeric micelles in porous and nanotubular implants as a new system for extended delivery of poorly soluble drugs. J Mater Chem. 2011;21:7082-7089.
31. Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drug-carriers using titania nanotube arrays. J Mater Chem. 2012;22: 6561-6563.
32. Vasilev K, Poh Z, Kant K, Chan J, Michelmore A, Losic D. Tailoring the surface functionalities of titania nanotube arrays. Biomaterials. 2010;31(3):532-540.
33. Kant K, Losic D. A simple approach for synthesis of TiO(2) nanotubes with through-hole morphology. Phys Status Solidi RRL. 2009;3(5): 139-141.
34. Gulati K, Aw MS, Losic D. Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection. Nanoscale Res Lett. 2011;6:571.
35. Popat KC, Leoni L, Grimes CA, Desai TA. Influence of engineered titania nanotubular surfaces on bone cells. Biomaterials. 2007;28(21): 3188-3197.
36. Roy P, Kim D, Lee K, Spiecker E, Schmuki P. TiO(2) nanotubes and their application in dye-sensitized solar cells. Nanoscale. 2010;2(1):45-59.
37. Wang S. Ordered mesoporous materials for drug delivery. Micropor Mesopor Mater. 2009;117(1-2):1-9.
38. Singhvi G, Singh M. Review: in-vitro drug release characterization models. Int J Pharm Studies Res. 2011;2(1):77-84.
39. Alpaslan E, Ercan B, Webster TJ. Anodized 20nm diameter nanotubular titanium for improved bladder stent applications. Int J Nanomedicine. 2011;6:219-225.
40. Gulati K, Aw MS, Losic D. Nano-engineered Ti wires for local delivery of chemotherapeutics in brain. Int J Nanomedicine. 2012;7: 2069-2076.