First case of combined small-cell lung cancer with adenocarcinoma harboring EML4-ALK fusion and an exon 19 EGFR mutation in each histological component

Journal of Thoracic Oncology

Volumn 7, Issue 12, 2012, Pages

  Toyokawa, Gouji ^a   Taguchi, Kenichi ^a   Ohba, Taro ^a   Morodomi, Yosuke ^a   Takenaka, Tomoyoshi ^a   Hirai, Fumihiko ^a   Yamaguchi, Masafumi ^a   Seto, Takashi ^a   Takenoyama, Mitsuhiro ^a   Sugio, Kenji ^a   Ichinose, Yukito ^a  

^a NATIONAL KYUSHU CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; OXALIPLATIN;

AGED; ARTICLE; BONE METASTASIS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; EXON; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LOBECTOMY; LUNG ADENOCARCINOMA; LUNG SMALL CELL CANCER; LYMPH NODE DISSECTION; MALE; PRIORITY JOURNAL; RECTUM CANCER;

EID: 84870310083     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3182762bcb     Document Type: Article

References (5)

1. Mitsudomi T, Morita S, Yatabe Y, et al.; West Japan Oncology Group. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-128.
2. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-566. (Pubitemid 47206930)
3. Scagliotti G, Stahel RA, Rosell R, Thatcher N, Soria JC. ALK translocation and crizotinib in non-small cell lung cancer: an evolving paradigm in oncology drug development. Eur J Cancer 2012;48:961-973.
4. Tatematsu A, Shimizu J, Murakami Y, et al. Epidermal growth factor receptor mutations in small cell lung cancer. Clin Cancer Res 2008;14:6092-6096.
5. Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011;3:75ra26.