Independent determinants of ascending aortic dilatation in hypertensive patients: Smoking, endothelial dysfunction, and increased epicardial adipose tissue

Blood Pressure Monitoring

Volumn 17, Issue 6, 2012, Pages 223-230

  Çetin, Mustafa ^a   Kocaman, Sinan Altan ^a   Durakoǧlugil, Murtaza Emre ^b   Erdoǧan, Turan ^b   Uǧurlu, Yavuz ^a   Doǧan, Sitki ^a   Çanga, Aytun ^a  

^a Rize Education and Research Hospital ^*  (Turkey)

^b RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

ascending aortic dilatation; endothelial dysfunction; epicardial adipose tissue; hypertension; smoking

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADIPOSE TISSUE; ADULT; AGED; AORTA DISEASE; AORTA FLOW; ARTERIAL WALL THICKNESS; ARTICLE; ASCENDING AORTIC DILATATION; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; EPICARDIAL ADIPOSE TISSUE; FEMALE; GROUPS BY AGE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SMOKING; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; ADULT; AORTA; AORTIC ANEURYSM; CAROTID INTIMA-MEDIA THICKNESS; DILATATION, PATHOLOGIC; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; ORGAN SIZE; PERICARDIUM; RISK FACTORS; SMOKING; TUNICA INTIMA;

EID: 84870302828     PISSN: 13595237     EISSN: 14735725     Source Type: Journal    
DOI: 10.1097/MBP.0b013e328359c4a7     Document Type: Article

References (43)

1. Clouse WD, Hallett JW Jr., Schaff HV, Gayari MM, Ilstrup DM, Melton LJ III. Improved prognosis of thoracic aortic aneurysms: a population-based study. JAMA 1998; 280:1926-1929. (Pubitemid 28559810)
2. Kim M, Roman MJ, Cavallini MC, Schwartz JE, Pickering TG, Devereux RB. Effect of hypertension on aortic root size and prevalence of aortic regurgitation. Hypertension 1996; 28:47-52. (Pubitemid 26231089)
3. Cuspidi C, Meani S, Fusi V, Valerio C, Sala C, Zanchetti A. Prevalence and correlates of aortic root dilatation in patients with essential hypertension: relationship with cardiac and extracardiac target organ damage. J Hypertens 2006; 24:573-580. (Pubitemid 43261922)
4. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994; 24:1468-1474. (Pubitemid 24344241)
5. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003; 108:2460-2466. (Pubitemid 37444406)
6. Marchington JM, Mattacks CA, Pond CM. Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties. Comp Biochem Physiol B 1989; 94:225-232.
7. Sacks HS, Fain JN. Human epicardial adipose tissue: a review. Am Heart J 2007; 153:907-917. (Pubitemid 46809849)
8. Taguchi R, Takasu J, Itani Y, Yamamoto R, Yokoyama K, Watanabe S, et al. Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 2001; 157:203-209. (Pubitemid 32539372)
9. Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 2005; 29:251-255. (Pubitemid 40320925)
10. Langewitz W, Tanner S. Validation of the PhysioQuant blood pressure measuring monitor in adults. Blood Press Monit 2009; 14:220-221.
11. Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003; 11:304-310. (Pubitemid 41127400)
12. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003; 88:5163-5168. (Pubitemid 37452712)
13. Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012; 30:445-448.
14. Reference Values for Arterial Stiffness' Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. Eur Heart J 2010; 31:2338-2350.
15. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelialdependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39:257-265. (Pubitemid 34084631)
16. Lilly LS. Pathophysiology of heart disease. 2nd ed. Baltimore, MD: Philadelphia, Pa: Lippincott Williams & Wilkins; 1997.
17. Kirsch EW, Radu NC, Allaire E, Loisance DY. Pathobiology of idiopathic ascending aortic aneurysms. Asian Cardiovasc Thorac Ann 2006; 14: 254-260. (Pubitemid 43871249)
18. Gardin JM, Arnold AM, Polak J, Jackson S, Smith V, Gottdiener J. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular Health Study). Am J Cardiol 2006; 97:270-275. (Pubitemid 43139250)
19. Baxter BT, Davis VA, Minion DJ,Wang YP, Lynch TG, McManus BM. Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments. J Vasc Surg 1994; 19:797-802, discussion 803.
20. Oxlund H, Andreassen TT. The roles of hyaluronic acid, collagen and elastin in the mechanical properties of connective tissues. J Anat 1980; 131:611-620. (Pubitemid 11203851)
21. Shah PK. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation 1997; 96:2115-2117. (Pubitemid 27425809)
22. Visscher TL, Seidell JC, Molarius A, van der Kuip D, Hofman A,Witteman JC. A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord 2001; 25:1730-1735. (Pubitemid 33052086)
23. Peiris AN, Sothmann MS, Hoffmann RG, Hennes MI,Wilson CR, Gustafson AB, et al. Adiposity, fat distribution, and cardiovascular risk. Ann Intern Med 1989; 110:867-872. (Pubitemid 19153771)
24. Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries. Int J Obes Relat Metab Disord 2002; 26:48-57. (Pubitemid 34098669)
25. Gorter PM, de Vos AM, van der Graaf Y, Stella PR, Doevendans PA, Meijs MF, et al. Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography. Am J Cardiol 2008; 102:380-385.
26. Canga A, Kocaman SA, Cetin M, Erdogan T, Durakoglugil ME, Cicek Y, et al. Increased epicardial adipose tissue thickness is correlated with ascending aortic diameter. Tohoku J Exp Med 2012; 226:183-190.
27. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med 2005; 2:536-543. (Pubitemid 41670345)
28. Hirata Y, Kurobe H, Akaike M, Chikugo F, Hori T, Bando Y, et al. Enhanced inflammation in epicardial fat in patients with coronary artery disease. Int Heart J 2011; 52:139-142.
29. Hirata Y, Tabata M, Kurobe H, Motoki T, Akaike M, Nishio C, et al. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol 2011; 58:248-255.
30. Bruun JM, Lihn AS,Verdich C, Pedersen SB, Toubro S, Astrup A, et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 2003; 285:E527-E533. (Pubitemid 37010830)
31. Tan KC, Xu A, Chow WS, Lam MC, Ai VH, Tam SC, et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 2004; 89:765-769. (Pubitemid 38269891)
32. Dick GM, Katz PS, Farias M III, Morris M, James J, Knudson JD, et al. Resistin impairs endothelium-dependent dilation to bradykinin, but not acetylcholine, in the coronary circulation. Am J Physiol Heart Circ Physiol 2006; 291:H2997-H3002. (Pubitemid 44904101)
33. Manzella D, Barbieri M, Rizzo MR, Ragno E, Passariello N, Gambardella A, et al. Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: effects of metabolic control. J Clin Endocrinol Metab 2001; 86:2769-2774. (Pubitemid 32545737)
34. Aydin H, Toprak A, Deyneli O, Yazici D, Tarcin O, Sancak S, et al. Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab Syndr Relat Disord 2010; 8:229-234.
35. Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol 2002; 39:683-688. (Pubitemid 34158166)
36. Huang PH, Leu HB, Chen JW, Cheng CM, Huang CY, Tuan TC, et al. Usefulness of attenuated heart rate recovery immediately after exercise to predict endothelial dysfunction in patients with suspected coronary artery disease. Am J Cardiol 2004; 93:10-13.
37. Şengu C, Duman D. The association of epicardial fat thickness with blunted heart rate recovery in patients with metabolic syndrome. Tohoku J Exp Med 2011; 224:257-262.
38. Medina F, de Haro J, Florez A, Acin F. Relationship between endothelial dependent vasodilation and size of abdominal aortic aneurysms. Ann Vasc Surg 2010; 24:752-757.
39. Sassalos K, Vlachopoulos C, Alexopoulos N, Gialernios T, Aznaouridis K, Stefanadis C. The acute and chronic effect of cigarette smoking on the elastic properties of the ascending aorta in healthy male subjects. Hellenic J Cardiol 2006; 47:263-268. (Pubitemid 47621129)
40. Tang LJ, Jiang JJ, Chen XF, Wang JA, Lin XF, Du YX, et al. Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome. J Zhejiang Univ Sci B 2010; 11: 592-598.
41. Miyata K, Shimokawa H, Kandabashi T, Higo T, Morishige K, Eto Y, et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol 2000; 20:2351-2358.
42. Shimokawa H, Ito A, Fukumoto Y, Kadokami T, Nakaike R, Sakata M, et al. Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor. J Clin Invest 1996; 97:769-776. (Pubitemid 26057096)
43. Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM. Periadventitial fat releases a vascular relaxing factor. FASEB J 2002; 16:1057-1063. (Pubitemid 34753512)