Epidemiology of viral hepatitis in Saudi Arabia: Are we off the hook

Saudi Journal of Gastroenterology

Volumn 18, Issue 6, 2012, Pages 349-357

  Abdo, Ayman A ^a   Sanai, Faisal M ^a,b   Al Faleh, Faleh Z ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

Author keywords

Epidemiology; hepatitis B; hepatitis C; incidence; prevalence

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

EPIDEMIC; HEPATITIS A; HEPATITIS A VIRUS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INCIDENCE; MORBIDITY; MORTALITY; PREVALENCE; REVIEW; SAUDI ARABIA; SEROPREVALENCE;

DISEASE OUTBREAKS; HEPATITIS, VIRAL, HUMAN; HUMANS; MORBIDITY; SAUDI ARABIA; SURVIVAL RATE;

EID: 84870283195     PISSN: 13193767     EISSN: 19984049     Source Type: Journal    
DOI: 10.4103/1319-3767.103425     Document Type: Review

References (73)

1. World Health Organization (WHO). Viral hepatitis: Report by the Secretariat. In: Sixty-Second World Health Assembly A62 / 22 Provisional Agenda Item 1217; 2009.
2. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006; 45:529-38. (Pubitemid 44307383)
3. World Health Organization (WHO). Initiative for Vaccine Research; 2010.
4. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005;5:558-67. (Pubitemid 41196755)
5. Xia GL, Liu CB, Cao HL, Bi SL, Zhan MY. Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992. Int Hepatol Commun 1996;5:62-73.
6. Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet 2000;355:887-91. (Pubitemid 30137669)
7. Ministry of Health of Saudi Arabia (MOH). A review of health situation. The Annual Health Statistics Book. Saudi Arabia: Saudi Arabia Ministry of Health
8. Al-Faleh FZ, Al-Jeffri M, Ramia S, Al-Rashed R, Arif M, Rezeig M, et al. Seroepidemiology of hepatitis B virus infection in Saudi children 8 years after a mass hepatitis B vaccination programme. J Infect 1999;38:167-70. (Pubitemid 29317385)
9. Sorrell MF, Belongia EA, Costa J, Gareen IF, Grem JL, Inadomi JM, et al. National institutes of health consensus development conference statement: Management of hepatitis B. Hepatology 2009;49(5 Suppl):S4-12.
10. Al-Tawfiq JA, Anani A. Profile of viral hepatitis A, B, and C in a Saudi Arabian hospital. Med Sci Monit 2008;14:CR52-6.
11. Arya SC, Ashraf SJ, Parande CM, el-Sayed M, Sahay R, Ageel AR, et al. Hepatitis B virus in Gizan, Saudi Arabia. J Med Virol 1985;17:267-74. (Pubitemid 16199296)
12. Parande CM, Arya SC, Ashraf SJ. Hepatitis B virus among Saudi children in Gizan, Saudi Arabia. Infection 1986;14:223-5. (Pubitemid 16002633)
13. Al-Faleh FZ, Ayoola EA, Arif M, Ramia S, Al-Rashed R, Al-Jeffry M, et al. Seroepidemiology of hepatitis B virus infection in Saudi Arabian children: A baseline survey for mass vaccination against hepatitis B. J Infect 1992;24:197-206.
14. Shobokshi OA, Serebour FE. The aetiology of acute viral hepatitis in the western region of Saudi Arabia. Trans R Soc Trop Med Hyg 1987;81:219-21.
15. Al-Faleh FZ. Changing pattern of hepatitis viral infection in Saudi Arabia in the last two decades. Ann Saudi Med 2003;23:367-71. (Pubitemid 37527007)
16. Al-Faleh F. Hepatitis B infection in Saudi Arabia. Ann Saudi Med 1988;8:474-80. (Pubitemid 19116133)
17. Al-Faleh FZ, Ayoola EA, Al-Jeffry M, Arif M, Al-Rashed RS, Ramia S. Integration of hepatitis B vaccine into the expanded program on immunization: The Saudi Arabian experience. Ann Saudi Med 1993;13:231-6. (Pubitemid 23281196)
18. Alfaleh F, Alshehri S, Alansari S, Aljeffri M, Almazrou Y, Shaffi A, et al. Long-term protection of hepatitis B vaccine 18 years after vaccination. J Infect 2008;57:404-9.
19. Alswaidi FM, O'brien SJ. Is there a need to include HIV, HBV and HCV viruses in the Saudi premarital screening program on the basis of their prevalence and transmission risk factors? J Epidemiol Community Health 2010:64:989-97.
20. Bashawri LA, Fawaz NA, Ahmad MS, Qadi AA, Almawi WY. Prevalence of seromarkers of HBV and HCV among blood donors in eastern Saudi Arabia, 1998-2001. Clin Lab Haematol 2004;26:225-8. (Pubitemid 38736867)
21. Mehdi SR, Pophali A, Al-Abdul Rahim KA. Prevalence of hepatitis B and C and blood donors. Saudi Med J 2000;21:942-4.
22. El-Hazmi MM. Prevalence of HBV, HCV, HIV-1, 2 and HTLV-I/II infections among blood donors in a teaching hospital in the Central region of Saudi Arabia. Saudi Med J 2004;25:26-33. (Pubitemid 38262504)
23. Madani TA. Hepatitis C virus infections reported in Saudi Arabia over 11 years of surveillance. Ann Saudi Med 2007;27:191-4. (Pubitemid 47062285)
24. Madani TA. Trend in incidence of hepatitis B virus infection during a decade of universal childhood hepatitis B vaccination in Saudi Arabia. Trans R Soc Trop Med Hyg 2007;101:278-83. (Pubitemid 46029791)
25. Al-Mazrou YY, Al-Jeffri M, Khalil MK, Al-Ghamdi YS, Mishkhas A, Bakhsh M, et al. Screening of pregnant Saudi women for hepatitis B surface antigen. Ann Saudi Med 2004;24:265-9. (Pubitemid 39136923)
26. Alrowaily MA, Abolfotouh MA, Ferwanah MS. Hepatitis B virus sero-prevalence among pregnant females in Saudi Arabia. Saudi J Gastroenterol 2008;14:70-2.
27. Memish ZA, Knawy BA, El-Saed A. Incidence trends of viral hepatitis A, B, and C seropositivity over eight years of surveillance in Saudi Arabia. Int J Infect Dis 2010;14:115-20.
28. El Beltagy KE, Al Balawi IA, Almuneef M, Memish ZA. Prevalence of hepatitis B virus markers among blood donors in a tertiary hospital in Tabuk, northwestern Saudi Arabia. Int J Infect Dis 2008;12:495-9.
29. Ayoola AE, Tobaigy MS, Gadour MO, Ahmad BS, Hamza MK, Ageel AM. The decline of hepatitis B viral infection in South-Western Saudi Arabia. Saudi Med J 2003;24:991-5. (Pubitemid 37259014)
30. Fathalla SE, Al-Jama AA, Al-Sheikh IH, Islam SI. Seroprevalence of hepatitis A virus markers in Eastern Saudi Arabia. Saudi Med J 2000;21:945-9.
31. Hajeer AH, Al Knawy B, Alhaj-Hussein BT, Al-Rubiaan SD. Hepatitis B virus: A study of genotypes in an infected Saudi cohort. Br J Biomed Sci 2007;64:93-4. (Pubitemid 46954332)
32. Abdo AA, Al-Jarallah BM, Sanai FM, Hersi AS, Al-Swat K, Azzam NA, et al. Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia. World J Gastroenterol 2006;12:7019-24. (Pubitemid 44834894)
33. Shobokshi OA, Serebour FE, Al-Drees AZ, Mitwalli AH, Qahtani A, Skakni LI. Hepatitis C virus seroprevalence rate among Saudis. Saudi Med J 2003;24:81-6.
34. Karkar A. Hepatitis C in dialysis units: The Saudi experience. Hemodial Int 2007;11:354-67. (Pubitemid 46958591)
35. WHO. World Health Organization Regional Committee for the Eastern Mediterranean; The growing threats of hepatitis B and C in the Eastern Mediterranean Region: A call for action. 2009. Available from http:// applications.emro.who.int/docs/EM-RC56-3-en.pdf. [Last accessed on 2012 Oct 10].
36. Al-Faleh FZ, Ayoola EA, Al-Jeffry M, Al-Rashed R, Al-Mofarreh M, Arif M, et al. Prevalence of antibody to hepatitis C virus among Saudi Arabian children: A community-based study. Hepatology 1991;14:215-8.
37. Fakeeh M, Zaki AM. Hepatitis C: Prevalence and common genotypes among ethnic groups in Jeddah, Saudi Arabia. Am J Trop Med Hyg 1999;61:889-92. (Pubitemid 30084108)
38. Abdelaal M, Rowbottom D, Zawawi T, Scott T, Gilpin C. Epidemiology of hepatitis C virus: A study of male blood donors in Saudi Arabia. Transfusion 1994;34:135-7. (Pubitemid 24059108)
39. Al-Faleh FZ, Huraib S, Sbeih F, Al-Karawi M, Al-Rashed R, Al-Mofleh IA, et al. Hepatitis C virus genotypes in patients with chronic liver disease and haemodialysis patients from Saudi Arabia. J Viral Hepat 1995:2:293-6.
40. Bosmans JL, Nouwen EJ, Behets G, Gorteman K, Huraib SO, Shaheen FA, et al. Prevalence and clinical expression of HCV-genotypes in haemodialysis patients of two geographically remote countries: Belgium and Saudi Arabia. Clin Nephrol 1997;47:256-62. (Pubitemid 27174112)
41. Shobokshi OA, Serebour FE, Skakni L, Al-Saffy YH, Ahdal MN. Hepatitis C genotypes and subtypes in Saudi Arabia. J Med Virol 1999;58:44-8. (Pubitemid 29172119)
42. Shobokshi OA, Serebour FE, Skakni LI. Hepatitis C genotypes/subtypes among chronic hepatitis patients in Saudi Arabia. Saudi Med J 2003;24 Suppl 2:S87-91. (Pubitemid 37160621)
43. Al-Traif I, Handoo FA, Al-Jumah A, Al-Nasser M. Chronic hepatitis C. Genotypes and response to antiviral therapy among Saudi patients. Saudi Med J 2004;25:1935-8.
44. Huraib S, Al-Rashed R, Aldrees A, Aljefry M, Arif M, Al-Faleh FA. High prevalence of and risk factors for hepatitis C in haemodialysis patients in Saudi Arabia: A need for new dialysis strategies. Nephrol Dial Transplant 1995;10:470-4.
45. Saudi Center for Organ Transplantation. Annual Report; 2006.
46. Mohamed WZ. Prevention of hepatitis C virus in hemodialysis patients: Five years experience from a single center. Saudi J Kidney Dis Transpl 2010;21:548-54.
47. Hussein MM, Mooij JM. Methods used to reduce the prevalence of hepatitis C in a dialysis unit. Saudi J Kidney Dis Transpl 2010;21:909-13.
48. Abu-Aisha H, Mitwalli A, Huraib SO, Al-Wakeel J, Abid J, Yousif KI, et al. The effect of chemical and heat disinfection of the hemodialysis machines on the spread of hepatitis C virus infection: A prospective study. Saudi J Kidney Dis Transpl 1995;6:174-8.
49. Soyannwo MA, Khan N, Kommajosyula S, Abdel Rahman AR, Khadaji M, Sing R, et al. Hepatitis C antibodies in haemodialysis and pattern of end-stage renal failure in Gassim, Saudi Arabia. Afr J Med Med Sci 1996;25:13-22.
50. Saxena AK, Panhotra BR, Sundaram DS, Naguib M, Venkateshappa CK, Uzzaman W, et al. Impact of dedicated space, dialysis equipment, and nursing staff on the transmission of hepatitis C virus in a hemodialysis unit of the middle east. Am J Infect Control 2003;31:26-33. (Pubitemid 36216572)
51. Al-Jiffri AM, Fadag RB, Ghabrah TM, Ibrahim A. Hepatitis C virus infection among patients on hemodialysis in Jeddah: A single center experience. Saudi J Kidney Dis Transpl 2003;14:84-9. (Pubitemid 36289804)
52. Karkar A, Abdelrahman M, Ghacha R, Malik TQ. Prevention of viral transmission in HD units: The value of isolation. Saudi J Kidney Dis Transpl 2006:17:183-8.
53. Alzahrani AJ, Dela Cruz DM, Obeid OE, Bukhari HA, Al-Qahtani A, Al- Ahdal MN. Molecular detection of hepatitis B, hepatitis C, and torque teno viruses in drug users in Saudi Arabia. J Med Virol 2009;81:1343-7.
54. Iqbal N. Substance dependence. A hospital based survey. Saudi Med J 2000;21:51-7. (Pubitemid 30082129)
55. Al Faleh F, Al Shehri S, Al Ansari S, Al Jeffri M, Al Mazrou Y, Shaffi A, et al. Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years. World J Gastroenterol 2008;14:7371-5.
56. Ashraf SJ, Arya SC, Parande CM, Kristensen E. Hepatitis A virus among natives and expatriates in Saudi Arabia. J Med Virol 1986;19:151-3. (Pubitemid 16046581)
57. Talukder MA, Waller DK, Nixon P, Al-Admawy AM. Prevalence of antibody to hepatitis A virus in a Saudi Arabian hospital population. J Infect Dis 1983;148:1167.
58. Al-Faleh FZ, Al-Jeffry M, Ramia H, Al-Rashed RS, Arif MA, Mohammed OM, et al. Hepatitis A in Saudi Arabia: A comparative sero-epidemiological study. Saudi Med J 1999;20:678-81.
59. Al Rashed RS. Prevalence of hepatitis A virus among Saudi Arabian children: A community-based study. Ann Saudi Med 1997;17:200-3. (Pubitemid 27405986)
60. Almuneef MA, Memish ZA, Balkhy HH, Qahtani M, Alotaibi B, Hajeer A, et al. Epidemiologic shift in the prevalence of hepatitis, A virus in Saudi Arabia: A case for routine hepatitis A vaccination. Vaccine 2006;24:5599-603. (Pubitemid 43867102)
61. Khalil M, Al-Mazrou Y, Al-Jeffri M, Al-Howasi M. Childhood epidemiology of hepatitis A virus in Riyadh, Saudi Arabia. Ann Saudi Med 1998;18:18-21. (Pubitemid 28306069)
62. World Health Organization (WHO). Hepatitis A. Geneva; 2000.
63. Feinstone SM. Hepatitis A virus. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases. New York: Churchill Livingstone; 2000. p. 1924-8.
64. El-Gilany A-H, Hammad S, Refaat K, Al-Enazi R. Seroprevalence of hepatitis A antibodies among children in a Saudi community. Asian Pacific J Trop Med 2010;3:278-82.
65. Ministry of Economy and Planning Saudi Arabia. Human Development Report; 2003.
66. Tufenkeji H. Hepatitis A shifting epidemiology in the Middle East and Africa. Vaccine 2000;18:S65-7. (Pubitemid 30100470)
67. Manno M, Camma C, Schepis F, Bassi F, Gelmini R, Giannini F, et al. Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years. Gastroenterology 2004;127:756-63. (Pubitemid 39208409)
68. Bortolotti F, Guido M, Bartolacci S, Cadrobbi P, Crivellaro C, Noventa F, et al. Chronic hepatitis B in children after e antigen seroclearance: Final report of a 29-year longitudinal study. Hepatology 2006;43:556-62.
69. Fattovich G, Brollo L, Giustina G, Noventa F, Pontisso P, Alberti A, et al. Natural history and prognostic factors for chronic hepatitis type B. Gut 1991;32:294-8.
70. Fattovich G. Natural history of hepatitis B. J Hepatol 2003;39:50-8.
71. Chen YC, Chu CM, Liaw YF. Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B. Hepatology 2010;51:435-44.
72. Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006;295:65-73. (Pubitemid 43042691)
73. Alghamdi AS, Sanai FM, Ismail M, Alghamdi H, Alswat K, Alqutub A, et al. SASLT practice guidelines: Management of hepatitis C virus infection. Saudi J Gastroenterol 2012;18 (suppl 1):1-32.