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The title of this Essay is a rephrasing from Shakespeare: "The plays's the thing." (Hamlet, Act II, Scene II), which signifies the importance of the "play within a play" in Hamlet"s quest for incontrovertible evidence of his uncle's guilt in the murder of his father. Here we assess the evidence for the case that microflow reactors provide more efficient results than flasks for homogeneous catalytic reactions
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The title of this Essay is a rephrasing from Shakespeare: "The plays's the thing." (Hamlet, Act II, Scene II), which signifies the importance of the "play within a play" in Hamlet"s quest for incontrovertible evidence of his uncle's guilt in the murder of his father. Here we assess the evidence for the case that microflow reactors provide more efficient results than flasks for homogeneous catalytic reactions.
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Noncontinuum molecular effects can be safely ignored in such liquid microreactors as Knudsen number Kn ≪ 1 (=λ/L, the ratio of the molecular mean free path A and the macroscopic lengthscale L).
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Noncontinuum molecular effects can be safely ignored in such liquid microreactors as Knudsen number Kn ≪ 1 (=λ/L, the ratio of the molecular mean free path A and the macroscopic lengthscale L).
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The strikingly nonlinear kinetics in catalyst concentration reported in reference [12]-a fourfold increase in catalyst loading reducing the reaction time from 40 h to 10 min-would seem to implicate catalyst deactivation even based on this simple end-point analysis
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The strikingly nonlinear kinetics in catalyst concentration reported in reference [12]-a fourfold increase in catalyst loading reducing the reaction time from 40 h to 10 min-would seem to implicate catalyst deactivation even based on this simple end-point analysis.
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The Omnical reaction calorimeter in which these batch reactions were carried out does not employ special reactors, special heat-transfer equipment, or special stirring, but simply a well-controlled isothermal environment. The reactor itself is exactly the vial shown in Figure 1 b, an off-the-shelf, disposable 16 mL glass GC/HPLC vial fitted with a plastic-coated magnetic stirring bar. Thus our protocols for carrying out reactions in flasks match those found in any standard organic chemistry laboratory
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The Omnical reaction calorimeter in which these batch reactions were carried out does not employ special reactors, special heat-transfer equipment, or special stirring, but simply a well-controlled isothermal environment. The reactor itself is exactly the vial shown in Figure 1 b, an off-the-shelf, disposable 16 mL glass GC/HPLC vial fitted with a plastic-coated magnetic stirring bar. Thus our protocols for carrying out reactions in flasks match those found in any standard organic chemistry laboratory.
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A recent report by Wirth and Brandt highlights the technical challenges that arise even when flow conditions are warranted on account of hazardous chemicals
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A recent report by Wirth and Brandt highlights the technical challenges that arise even when flow conditions are warranted on account of hazardous chemicals: J. C. Brandt, T. Wirth, Beilstein J. Org. Chem 2007, 5, No.30.
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Personal communication, S. P. Mathew, Chemical Research and Development, Reaction Engineering, Pfizer Global R&D
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Personal communication, S. P. Mathew, Chemical Research and Development, Reaction Engineering, Pfizer Global R&D.
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