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Volumn 49, Issue 14, 2010, Pages 2478-2485

The flow's the thing.or is it? assessing the merits of homogeneous reactions in flask and flow

Author keywords

Kinetics; Microreactors; Organocatalysis; Reaction mechanisms

Indexed keywords

CATALYTIC REACTIONS; DETECTION DEVICE; HOMOGENEOUS REACTION; IN-SITU; INTRINSIC KINETICS; MICRO REACTOR; MICRO-FLOW REACTOR; ORGANOCATALYSIS; REACTION FLASK; REACTION MECHANISM; REACTION MECHANISMS; REACTION PROTOCOLS;

EID: 77950274370     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200906095     Document Type: Review
Times cited : (175)

References (37)
  • 1
    • 77950219826 scopus 로고    scopus 로고
    • The title of this Essay is a rephrasing from Shakespeare: "The plays's the thing." (Hamlet, Act II, Scene II), which signifies the importance of the "play within a play" in Hamlet"s quest for incontrovertible evidence of his uncle's guilt in the murder of his father. Here we assess the evidence for the case that microflow reactors provide more efficient results than flasks for homogeneous catalytic reactions
    • The title of this Essay is a rephrasing from Shakespeare: "The plays's the thing." (Hamlet, Act II, Scene II), which signifies the importance of the "play within a play" in Hamlet"s quest for incontrovertible evidence of his uncle's guilt in the murder of his father. Here we assess the evidence for the case that microflow reactors provide more efficient results than flasks for homogeneous catalytic reactions.
  • 11
    • 70350348246 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2009, 48, 8547-8550.
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 8547-8550
  • 20
    • 77950276059 scopus 로고    scopus 로고
    • Noncontinuum molecular effects can be safely ignored in such liquid microreactors as Knudsen number Kn ≪ 1 (=λ/L, the ratio of the molecular mean free path A and the macroscopic lengthscale L).
    • Noncontinuum molecular effects can be safely ignored in such liquid microreactors as Knudsen number Kn ≪ 1 (=λ/L, the ratio of the molecular mean free path A and the macroscopic lengthscale L).
  • 25
    • 77950251532 scopus 로고    scopus 로고
    • The strikingly nonlinear kinetics in catalyst concentration reported in reference [12]-a fourfold increase in catalyst loading reducing the reaction time from 40 h to 10 min-would seem to implicate catalyst deactivation even based on this simple end-point analysis
    • The strikingly nonlinear kinetics in catalyst concentration reported in reference [12]-a fourfold increase in catalyst loading reducing the reaction time from 40 h to 10 min-would seem to implicate catalyst deactivation even based on this simple end-point analysis.
  • 28
    • 77950269397 scopus 로고    scopus 로고
    • The Omnical reaction calorimeter in which these batch reactions were carried out does not employ special reactors, special heat-transfer equipment, or special stirring, but simply a well-controlled isothermal environment. The reactor itself is exactly the vial shown in Figure 1 b, an off-the-shelf, disposable 16 mL glass GC/HPLC vial fitted with a plastic-coated magnetic stirring bar. Thus our protocols for carrying out reactions in flasks match those found in any standard organic chemistry laboratory
    • The Omnical reaction calorimeter in which these batch reactions were carried out does not employ special reactors, special heat-transfer equipment, or special stirring, but simply a well-controlled isothermal environment. The reactor itself is exactly the vial shown in Figure 1 b, an off-the-shelf, disposable 16 mL glass GC/HPLC vial fitted with a plastic-coated magnetic stirring bar. Thus our protocols for carrying out reactions in flasks match those found in any standard organic chemistry laboratory.
  • 33
    • 75949124413 scopus 로고    scopus 로고
    • A recent report by Wirth and Brandt highlights the technical challenges that arise even when flow conditions are warranted on account of hazardous chemicals
    • A recent report by Wirth and Brandt highlights the technical challenges that arise even when flow conditions are warranted on account of hazardous chemicals: J. C. Brandt, T. Wirth, Beilstein J. Org. Chem 2007, 5, No.30.
    • (2007) Beilstein J. Org. Chem , vol.5 , Issue.30
    • Brandt, J.C.1    Wirth, T.2
  • 34
    • 77950207259 scopus 로고    scopus 로고
    • Personal communication, S. P. Mathew, Chemical Research and Development, Reaction Engineering, Pfizer Global R&D
    • Personal communication, S. P. Mathew, Chemical Research and Development, Reaction Engineering, Pfizer Global R&D.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.