PET/MRI: Challenges, solutions and perspectives

Zeitschrift fur Medizinische Physik

Volumn 22, Issue 4, 2012, Pages 281-298

  Herzog, Hans ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

APD; Hybrid scanner; Magnetic resonance imaging; MR PET; PET MRI; Positron emission tomography; SiPM

Indexed keywords

ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC IMAGING; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE QUALITY; IMAGING SYSTEM; MAGNETIC FIELD; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCESS DEVELOPMENT; SCINTILLATION; SIGNAL PROCESSING; WHOLE BODY IMAGING;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CARBON RADIOISOTOPES; CONTRAST MEDIA; DIFFUSION MAGNETIC RESONANCE IMAGING; EFFICIENCY; ELECTRON SPIN RESONANCE SPECTROSCOPY; EQUIPMENT DESIGN; FLUORODEOXYGLUCOSE F18; HODGKIN DISEASE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MODELS, ANIMAL; POSITRON-EMISSION TOMOGRAPHY; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RACLOPRIDE; RATS; SENSITIVITY AND SPECIFICITY; SOFTWARE; WHOLE BODY IMAGING; YOUNG ADULT;

EID: 84870253857     PISSN: 09393889     EISSN: 18764436     Source Type: Journal    
DOI: 10.1016/j.zemedi.2012.07.003     Document Type: Article

References (80)

1. Pietrzyk U., Herholz K., Heiss W.D. Three-dimensional alignment of functional and morphological tomograms. J Comput Assist Tomogr 1990, 14:51-59.
2. Burger C., Buck A. Requirements and implementation of a flexible kinetic modeling tool. J Nucl Med 1997, 38:1818-1823.
3. Townsend D.W. A combined PET/CT scanner: the choices. J Nucl Med 2001, 42:533-534.
4. Antoch G., Saoudi N., Kuehl H., Dahmen G., Mueller S.P., Beyer T., et al. Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol 2004, 22:4357-4368.
5. Skalski J., Wahl R.L., Meyer C.R. Comparison of mutual information-based warping accuracy for fusing body CT and PET by 2 methods: CT mapped onto PET emission scan versus CT mapped onto PET transmission scan. J Nucl Med 2002, 43:1184-1187.
6. Beyer T., Townsend D.W., Brun T. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000, 41:1369-1379.
7. Townsend D.W., Beyer T. A combined PET/CT scanner: the path to true image fusion. Brit J Rad 2002, 75:S24-S30.
8. Seemann M.D. Whole-body PET/MRI: the future in oncological imaging. Technol Cancer Res Treat 2005, 4:577-582.
9. Zaidi H., Mawlawi O., Orton C.G. Simultaneous PET/MR will replace PET/CT as the molecular multimodality imaging platform of choice. Med Phys 2007, 34:1525-1528.
10. von Schulthess G.K., Schlemmer H.P.W. A look ahead: PET/MR versus PET/CT. Eur J Nucl Med Mol Imaging 2009, 36(Suppl. 1):S3-S9.
11. Ranin P, Tripathi A, Arisaka K, Akhanjee S, Barnhill D, Howard C, Jillings C, Ohnuki T, Slater W. Study of the influence of the earth's magnetic field on PMTs for Pierre-Auger surface detectors. http://www.physics.ucla.edu/~arisaka/auger/UCLA_GAP_Notes/gap_2001_006.pdf.
12. Pichler B., Wehrl H.F., Kolb A., Judenhofer M.S. Pet/mri: the next generation of multi-modality imaging?. Semin Nucl Med 2008, 38:199-208.
13. Herholz K., Westwood S., Haense C., Dunn G. Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairment. J Nucl Med 2011, 52:1218-1226.
14. Chassoux F., Rodrigo S., Semah F., Beuvon F., Landre E., Devaux B., et al. FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias. Neurology 2010, 75:2168-2175.
15. Langen K.J., Floeth F.W., Stoffels G., Hamacher K., Coenen H.H., Pauleit D. Improved diagnostics of cerebral gliomas using FET PET. Z Med Phys 2007, 17:237-241.
16. Pauleit D., Floeth F., Hamacher K., Riemenschneider M.J., Reifenberger G., Müller H.W., et al. O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with magnetic resonance imaging improves the diagnostic assessment of cerebral gliomas. Brain 2005, 128:678-687.
17. Pöpperl G., Kreth F.W., Mehrkens J.H., Herms J., Seelos K., Koch W., et al. FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. Eur J Nucl Med Mol Imaging 2007, 34:1933-1942.
18. Stadlbauer A., Pölking E., Prante O., Nimsky C., Buchfelder M., Kuwert T., et al. Detection of tumour invasion into the pyramidal tract in glioma patients with sensorimotor deficits by correlation of (18)F-fluoroethyl-L-tyrosine PET and magnetic resonance diffusion tensor imaging. Acta Neurochir 2009, 151:1061-1069.
19. Stadlbauer A., Prante O., Nimsky C., Salomonowitz E., Buchfelder M., Kuwert T., et al. Metabolic imaging of cerebral gliomas: spatial correlation of changes in O-(2-18F-fluoroethyl)-L-tyrosine PET and proton magnetic resonance spectroscopic imaging. J Nucl Med 2008, 49:721-729.
20. Wehrl H.F., Judenhofer M.S., Wiehr S., Pichler B. Pre-clinical PET/MRI: technological advances and new perspectives in biomedical research. Eur J Nucl Med Mol Imaging 2009, 36(Suppl. 1):S56-S68.
21. Herzog H., Pietrzyk U., Shah N.J., Ziemons K. The current state, challenges and perspectives of MR-PET. Neuroimage 2010, 49:2072-2082.
22. Shao Y., Cherry S.R., Farahani K., Slates R., Silverman R.W., Meadors K., et al. Development of a PET detector system compatible with MRI/NMR systems. IEEE Trans Nucl Sci 1997, 44:1167-1171.
23. Shao Y., Cherry S.R., Farahani K., Meadors K., Siegel S., Silverman R.W., et al. Simultaneous PET and MR imaging. Phys Med Biol 1997, 42:1965-1970.
24. Mackewn J.E., Strul D., Charles-Edwards G., Totman J.J., Hallett W.A., Halsted P., et al. Performance evaluation and MR compatibility assessment of an optical fibre based pre-clinical MR-compatible PET scanner. IEEE NSS-MIC conf record 2008, 4662-4666.
25. Mackewn J.E., Halsted P., Charles-Edwards G., Page R., Totman J.J., Sunassee K., et al. Performance evaluation of an MRI-compatible pre-clinical PET system using long optical fibers. IEEE Trans Nucl Sci 2010, 57:1052-1062.
26. Raylman R.R., Majewski S., Lemieux S.K., Velan S.S., Kross B., Popov V., et al. Simultaneous MRI and PET imaging of a rat brain. Phys Med Biol 2006, 51:371-379.
27. Lucas A.J., Hawkes R.C., Ansorge R.E., Williams G.B., Nutt R.E., Clark J.C., et al. Development of a combined microPET-MR system. Technol Cancer Res Treat 2006, 5:337-341.
28. Hawkes R.C., Fryer T.D., Siegel S., Ansorge R.E., Carpenter T.A. Preliminary evaluation of a combined microPET-MR system. Technol Cancer Res Treat 2010, 9:53-60.
29. Handler W.B., Gilbert K.M., Peng H., Chronik B.A. Simulation of scattering and attenuation of 511 keV photons in a combined PET/Field-cycled MRI system. Phys Med Biol 2006, 51:2479-2491.
30. Bindseil G.A., Gilbert K.M., Scholl T.J., Handler W.B., Chronik B.A. First image from a combined positron emission tomography and field-cycled MRI system. Magn Res Med 2011, 66:301-305.
31. Catana C., Wu Y., Judenhofer M.S., Qi J., Pichler B.J., Cherry S.R. Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J Nucl Med 2006, 47:1968-1976.
32. Pichler B.J., Judenhofer M.S., Catana C., Walton J.H., Kneilling M., Nutt R.E., et al. Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. J Nucl Med 2006, 47:639-647.
33. Judenhofer M.S., Catana C., Swann B.K., Siegel S.B., Jung W.I., Nutt R.E., et al. PET/MRI images, acquired with a compact MRI compatible PET detector in a 7 Tesla magnet. Radiology 2007, 244:807-814.
34. Schlyer D., Vaska P., Tomasi D., Woody C., Maramraju S.H., Southekal S., et al. A simultaneous PET/MRI scanner based on RatCAP in small animals. IEEE NSS-MIC conf record 2007, 3256-3259.
35. Maramraju S.H., Smith S.D., Junnarkar S.S., Schulz D., Stoll S., Ravindranath B., et al. Small animal simultaneous PET/MRI: initial experiences in a 9.4 T microMRI. Phys Med Biol 2011, 56:2459-2480.
36. Schmand M., Burbar Z., Corbeil J., Zhang N., Michel C., Byars L., et al. BrainPET: First human tomograph for simultaneous (functional) PET and MR imaging. J Nucl Med 2007, 48(Suppl. 2):310P.
37. Schlemmer H.P., Pichler B., Schmand M., Burbar Z., Michel C., Ladebeck R., et al. Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 2008, 248:1028-1035.
38. Yamamoto S., Mazumoto K., Senda M. Development of a multi-slice dual layer MRcompatible animal PET system using DOI detectors. J Nucl Med 2007, 48(Suppl. 2):89P.
39. Yamamoto S., Imaizumi M., Kanai Y., Tatsumi M., Aoki M., Sugiyama E., et al. Design and performance from an integrated PET/MRI system for small animals. Ann Nucl Med 2010, 24:89-98.
40. Cho Z.H., Son Y.D., Kim H.K., Kim K.N., Oh S.H., Han J.Y. A fusion PET-MRI system with a highresolution research tomograph-PET and ultra-high field 7.0T-MRI for the molecular-genetic imaging of the brain. Proteomics 2008, 8:1302-1323.
41. Zaidi H., Ojha N., Morich M., Griesmer J., Hu Z., Maniawski P., et al. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol 2011, 56:3091-3106.
42. Schmid D, Samarin A, Kuhn F, Crook D, Hodler JM, Von Schulthess G. Image Registration Accuracy of a Sequential, Trimodality PET/CT+MR Imaging Setup Using Dedicated Patient Transporter Systems. 2011; http://m.rsna.org/rsna2011/program/event_display.cfm%3Fem_id=11012910.
43. Nagy K., Nemeth G., Major P., Nyitrai Z., Máthé D., Gulyás B., et al. Presentation of test measurements with a commercial small animal PET/MRI imaging system. J Nucl Med 2011, 52(Suppl. 1):259.
44. Delso G., Fürst S., Jakoby B., Ladebecke R., Ganter C., Nekolla S.G., et al. Performance measurements of the Siemens mMR integrated whole-Body PET/MRI scanner. J Nucl Med 2011, 52:1914-1922.
45. Schulz V., Weissler B., Gebhardt P., Solf T., Lerche C.W., Fischer P. SiPM based preclinical PET/MR insert for a human 3T MR: first imaging experiments. IEEE NSS-MIC conf record 2011, 4467-4469.
46. Yoon H.S., Ko G.B., Kwon S.I., Lee C.M., Ito M., Chan Song I., et al. Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner. J Nucl Med. 2012, 53(4):608-614.
47. Pichler B., Lorenz E., Mirzoyan R., Pimpl W., Roder F., Schwaiger M., et al. Performance test of a LSO-APD PET module in a 9.4 tesla magnet. IEEE NSS-MIC conf record 1998, 1237-1239.
48. Judenhofer M.S., Wehrl H.F., Newport D.F., Catana C., Siegel S.B., Becker M., et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nature Medicine 2008, 14:459-465.
49. Wehrl H.F., Sauter A.W., Judenhofer M.S., Pichler B.J. Combined PET/MRI imaging-technology and applications. Technol Cancer Res Treat 2010, 9:5-20.
50. Zaidi H., Del Guerra A. An outlook on future design of hybrid PET/MRI systems. Med Phys 2011, 38:5667-5689.
51. Yamamoto S., Watabe H., Kanai Y., Aoki M., Sugiyama, Watabe T., et al. Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/MRI system. Phys Med Biol 2011, 56:4147-4159.
52. Schulz V., Solf T., Weissler B., Gebhardt P., Fischer P., Ritzert M., et al. A preclinical PET/MR insert for a human 3T MR scanner. IEEE NSS-MIC conf record 2009, 2577-2579.
53. Solf T., Schulz V., weissler B., Thon A., Fischer P., Ritzert M., et al. Solid-state detector stack for ToF-PET/MR. IEEE NSS-MIC conf record 2009, 2798-2799.
54. Yao R., Seidel J., Liow J.S., Green M.V. Attenuation Correction for the NIH ATLAS Small Animal PET Scanner. IEEE Trans Nucl Sci 2005, 52:664-668.
55. Visser E.P., van Dalen J.A., Laverman P., Newport D., Corstens F.H.M., Oyen W.J.G., et al. Evaluation of attenuation correction in the InveonTM preclinical PET scanner using two opposite, rotating 57Co point sources. Eur J Nucl Med Mol Imaging 2007, 34(Suppl. 2):S227.
56. D'Ambrosio D., Spinelli A.E., Boschi S., Quarta C., Franchi R., Pagotto U., et al. Attenuation correction for pre-clinical PET images using a small animal CT scanner. Eur J Nucl Med Mol Imaging 2007, 34(Suppl. 2):S227.
57. Grazioso R., Ladebeck R., Schmand M., Krieg N. APD-based PET for combined MR-PET imaging detector. Proceedings of the ISRMRM 13th Scientific Meeting 2005, http://cds.ismrm.org/ismrm-2005/Files/00408.pdf.
58. Newport D.F., Siegel S.B., Swann B.K., Atkins B.E., McFarland A.R., Pressley D.R., et al. QuickSilver: A flexible, extensible, and high-speed architecture for multi-modality. IEEE NSS-MIC conf record 2006, 2333-2334.
59. Kolb A., Wehrl H.F., Hofmann M., Judenhofer M.S., Eriksson L., Ladebeck R., et al. Technical Performance Evaluation of a Human Brain PET/MRI System. Europ Rad 2012, 22:1776-1788.
60. Herzog H., Langen K.J., Weirich C., Rota Kops E., Kaffanke J., Tellmann L., et al. High resolution BrainPET combined with simultaneous MRI. Nuklearmedizin 2011, 50:74-82.
61. Bergstrom M., Litton J., Eriksson L., Bohm C., Blomqvist G. Determination of object contour from projections for attenuation correction in cranial positron emission tomography. J Comput Assist Tomogr 1982, 6:365-372.
62. Wagenknecht G., Rota Kops E., Tellmann L., Herzog H. Knowledge-based segmentation of attenuation-relevant regions of the head in T1-weighted MR images for attenuation correction in MR/PET systems. IEEE NSS-MIC conf record 2009, 3338-3343.
63. Hofmann M., Steinke F., Scheel V., Charpiat G., Farquhar J., Aschoff P., et al. MRI-based attenuation correction for PET/MRI: A novel approach combining pattern recognition and atlas registration. J Nucl Med 2008, 49:1875-1883.
64. Keereman V., Fierens Y., Broux T., De Deene Y., Lonneux M., Vandenberghe S. MRI-based attenuation correction for PET/MRI using ultrashort echo time sequences. J Nucl Med 2010, 51:812-818.
65. Catana C., van der Kouwe A., Benner T., Michel C.J., Hamm M., Fenchel M., et al. Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype. J Nucl Med 2010, 51:1431-1438.
66. Berker Y., Franke J., Salomon A., Palmowski M., Donker H.C., Temur Y., et al. MRI-Based Attenuation correction for hybrid PET/MRI systems: A 4-class tissue segmentation technique using a combined ultrashort-echo-time/Dixon MRI sequence. J Nucl Med 2012, 53:796-804.
67. Montandon M.L., Zaidi H. Atlas-guided non-uniform attenuation correction in cerebral 3D PET imaging. Neuroimage 2005, 25:278-286.
68. Rota Kops E., Herzog H. Template based attenuation correction for PET in MR-PET scanners. IEEE NSS-MIC conf record 2008, 3786-3789.
69. Ashburner J., Friston K.J. Nonlinear spatial normalization using basis functions. Hum Brain Mapp 1999, 70:254-266.
70. Herzog H., Langen K.J., Kaffanke J., Weirich C., Neuner I., Stoffels G., et al. MR-PET opens new horizons in neuroimaging. Future Neurol 2010, 5:807-815.
71. Boss A., Bisdas S., Kolb A., Hofmann M., Ernemann U., Claussen C.D., et al. Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med 2010, 51:1198-1205.
72. Boss A., Stegger L., Bisdas S., Kolb A., Schwenzer N., Pfister M., et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area. Eur Radiol 2011, 21:1439-1446.
73. Boss A., Kolb A., Hofmann M., Bisdas S., Nägele T., Ernemann U., et al. Diffusion tensor imaging in a human PET/MR hybrid system. Invest Radiol 2010, 45:270-274.
74. Wittsack H.J., Ritzl A., Mödder U. User friendly analysis of MR investigations of the cerebral perfusion: Windows(R)-based image processing. Rofo 2002, 174:742-746.
75. Standards Publication NU 2-2007. Performance Measurements of Positron Emission Tomographs 2007, NEMA, National Electrical Manufacturers Association, Rosslyn, VA.
76. Catana C., Benner T., van der Kouwe A., Byars L., Hamm M., Chonde D.B., et al. MRI-assisted PET motion correction for neurologic studies in an integrated MR-PET scanner. J Nucl Med 2011, 52:154-161.
77. Cho Z.H., Han J.Y., Hwang S.I., Kim D.S., Kim K.N., Kim N.B., et al. Quantitative analysis of the hippocampus using images obtained from 7.0 T MRI. Neuroimage 2010, 49:2134-2140.
78. Cho Z.H., Son Y.D., Kim H.K., Choi E.J., Lee S.Y., Chi J.G., et al. Observation of glucose metabolism in the thalamic nuclei by fusion PET/MRI. J Nucl Med 2011, 52:401-404.
79. Surti S., Kuhn A., Werner M.E., Perkins A.E., Kolthammer J., Karp J.S. Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. J Nucl Med 2007, 48:471-480.
80. Schulz V., Torres-Espallardo I., Renisch S., Hu Z., Ojha N., Börnert P., et al. Automatic, three-segment, MR-based attenuation correction for whole-body PET/MRI data. Eur J Nucl Med Mol Imaging 2010, 38:138-152.