The role of nitrates in the prevention of preeclampsia: An update

Current Opinion in Obstetrics and Gynecology

Volumn 24, Issue 6, 2012, Pages 361-367

  Kalidindi, Madhavi ^a   Velauthar, Luxmi ^a   Khan, Khalid ^b   Aquilina, Joseph ^a  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

L arginine, nitrates; nitric oxide donors; pentaerythrityl tetranitrate; preeclampsia

Indexed keywords

ARGININE; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; ISOSORBIDE MONONITRATE; NIFEDIPINE; NITRIC ACID DERIVATIVE; PENTAERYTHRITYL TETRANITRATE; PHOSPHODIESTERASE INHIBITOR; PLACEBO; PLASMA SUBSTITUTE; S NITROGLUTATHIONE; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ARTERY RESISTANCE; BED REST; BLOOD LEVEL; BLOOD PRESSURE REGULATION; DIARRHEA; DIET SUPPLEMENTATION; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG MEGADOSE; HEADACHE; HUMAN; HYDRATION; INTRAVENOUS ADMINISTRATION; LOW DRUG DOSE; MATERNAL BLOOD; MULTICENTER STUDY (TOPIC); ORTHOSTATIC HYPOTENSION; PLACENTA CIRCULATION; PREECLAMPSIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SECOND TRIMESTER PREGNANCY; SKIN IRRITATION; TREATMENT DURATION; TREATMENT OUTCOME; UMBILICAL CORD BLOOD; UNSPECIFIED SIDE EFFECT; URINE LEVEL; UTERINE ARTERY; VASODILATATION;

FEMALE; HUMANS; NITRATES; NITRIC OXIDE DONORS; PRE-ECLAMPSIA; PREGNANCY;

EID: 84870249842     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32835a31de     Document Type: Review

References (47)

1. Granger JP, Alexander BT, Llinas MT, et al. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension 2001; 38 (part2):718-722.
2. Buhimschi IA, Saade GR, Chwalisz K, Garfield RE. The nitric oxide pathway in preeclampsia: pathophysiological implications. Hum Reprod Update 1998; 4:25-42. (Pubitemid 28223053)
3. Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997; 272:R441-R463.
4. Lopez-Jaramillo P, Arenas WD, Garcia RG, et al. Review: the role of the L-arginine-nitric oxide pathway in preeclampsia. Ther Adv Cardiovasc Dis 2008; 2:261-275.
5. Maul H, Longo M, Saade GR, Garfield RE. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharmaceut Des 2003; 9:359-380. (Pubitemid 36131729)
6. Seligman SP, Buyon JP, Clancy RM, et al. The role of nitric oxide in the pathogenesis of preeclampsia. Am J Obstet Gynecol 1994; 171:944-948. (Pubitemid 24341474)
7. Nishizawa H, Pryor-Koishi K, Suzuki M, et al. Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of preeclampsia. Gynecol Obstet Invest 2009; 68:239-247.
8. Curtis NE, Gude NM, King RG, et al. Nitric oxide metabolites in normal human pregnancy and preeclampsia. Hypertens Pregnancy 1995; 14:339-349.
9. Hata T, Hashimoto M, Kanenishi K, et al. Maternal circulating nitrite levels decreased in both normal normotensive pregnancies and pregnancies with preeclampsia. Gynecol Obstet Invest 1999; 48:93-97. (Pubitemid 29397118)
10. Davidge ST, Stranko CP, Roberts JM. Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia. Am J Obstet Gynaecol 1996; 174:1008-1013. (Pubitemid 26111684)
11. Schiessl B, Strasburger C, Bidlingmaier M, et al. Plasma-and urine-concentration of nitrite/nitrate and cyclic guanosine monophosphate in intrauterine growth restricted and preeclamptic pregnancies. Arch Gynecol Obstet 2006; 274:150-154. (Pubitemid 43781421)
12. Norris LA, Higgins JR, Darling MRN, et al. Nitric oxide in the uteroplacental fetoplacental, and peripheral circulations in preeclampsia. Obstet Gynaecol 1999; 93:958-963. (Pubitemid 29247103)
13. Lyall F, Young A, Greer IA. Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am J Obstet Gynecol 1995; 173:714-718.
14. Rowe J, Campbell S, Gallery EDM. Nitric oxide production by decidual endothelial cells is not reduced in preeclampsia. Hypertens Pregnancy 2003; 22:63-75. (Pubitemid 36205809)
15. Orpana AK, Avela K, Ranta V, et al. The calcium-dependent nitric oxide production of human vascular endothelial cells in preeclampsia. Am J Obstet Gynaecol 1996; 174:1056-1060. (Pubitemid 26111693)
16. De Pace V, Chiossi G, Facchinetti F. Clinical use of nitric oxide donors and L-arginine in obstetrics. J Matern Fetal Med 2007; 20:569-579. (Pubitemid 47221556)
17. Gori T, Daiber A. Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate. Am J Cardiovasc Drugs 2009; 9:7-15.
18. Megson IL, Webb DJ. Nitric oxide donor drugs: current status and future trends. Expert Opin Investig Drugs 2002; 11:587-601. (Pubitemid 34520612)
19. Lehmann J. Nitric oxide donors: current trends in therapeutic applications. Expert Opin Ther Patents 2000; 10:559-574. (Pubitemid 30251753)
20. Miller MR, Megson IL. Recent developments in nitric oxide donor drugs. Br J Pharmacol 2007; 151:305-321. (Pubitemid 46842668)
21. Hinz B, Kuntze U, Schroder H. Pentaerithrityl tetranitrate and its phase I metabolites are potent activators of cellular cyclic GMP accumulation. Biochem Biophys Res Commun 1998; 253:658-661. (Pubitemid 29039198)
22. Parker JC, Davidson IWF. Organic nitrates in perspective. Drug Metab Rev 1975; 4:135-138.
23. Meher S, Duley L. Nitric oxide for preventing preeclampsia and its complications. Cochrane Database Syst Rev 2007; (2):CD006490. doi: 0.1002/14651858.CD006490.
24. Lees C. Nitric oxide donors in obstetrics and gynaecology. Schwarz Pharma Scientific Forum, Cornelius Limbach GmbH, Kö ln, Germany; March 1996.
25. Luzi G, Caserta G, Iammarino G, et al. Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild preeclampsia and threatened preterm labour. Ultrasound Obstet Gynecol 1999; 14/2:101-109. (Pubitemid 29440651)
26. Cacciatore B, Halmesmaki E, Kaaja R, et al. Effects of transdermal nitroglycerine on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation. Am J Obstet Gynecol 1998; 179/1:140-145. (Pubitemid 28394487)
27. Kahler C, Schleussner E, Moller A, Seewald HJ. Nitric oxide donors: effects on fetoplacental blood flow. Eur J Obstet Gynecol Reprod Biol 2004; 115/1:10-14. (Pubitemid 38844210)
28. Valensise H, Vasapollo B, Novelli GP, et al. Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery. Ultrasound Obstet Gynecol 2008; 31:55-64. (Pubitemid 351211932)
29. Trapani A, Goncalvest LF, Pires MM. Transdermal nitroglycerine in patients with severe preeclampsia with placental insufficiency: effect on Doppler velocimetry of the uterine, umbilical and middle cerebral arteries. Ultrasound Obstet Gynaecol 2011; 38:389-394.
30. Martinez-Abundis E, Gonzalez-Ortiz M, Hernandez-Salazar F, Huerta-J-Lucas M. Sublingual isosorbide dinitrate in the acute control of hypertension in patients with severe preeclampsia. Gynecol Obstet Invest 2000; 50: 39-42. (Pubitemid 30445754)
31. Amit A, Thaler I, Paz Y, Itskovitz-Eldor J. The effect of a nitric oxide donor on Doppler flow velocity waveforms in the uterine artery during the first trimester of pregnancy. Ultrasound Obstet Gynecol 1998; 11:94-98. (Pubitemid 28175009)
32. Makino Y, Izumi H, Makino I, Shirakawa K. The effect of nitric oxide on uterine and umbilical artery flow velocity waveform in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 73:139-143. (Pubitemid 27285978)
33. Nakatsuka M, Tada K, Kimura Y, et al. Clinical experience of long-term transdermal treatment with nitric oxide donor for women with preeclampsia. Gynecol Obstet Invest 1999; 47:13-19. (Pubitemid 29026889)
34. Lees C, Langford E, Brown AS, et al. S-nitrosoglutathione in severe preeclampsia. Obstet Gynecol 1996; 88:14-19.
35. Neri I, Jasonni VM, Gori GF, et al. Effects of L-arginine on blood pressure in pregnancy-induced hypertension: a randomised placebo-controlled trial. J Maternal Fetal Neonatal Med 2006; 19:277-281. (Pubitemid 43879993)
36. Rytlewski K, Olszanecki R, Korbut R, Zdebski Z. Effects of prolonged oral supplementation with L-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest 2005; 35:32-37. (Pubitemid 40187952)
37. Hladunewich MA, Derby GC, Lafayette RA, et al. Effect of L-arginine therapy on the glomerular injury of preeclampsia. Obstet Gynaecol 2006; 107:886-895.
38. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with preeclampsia. Acta Obstet Gynecol Scand 2004; 83:103-107. (Pubitemid 38121737)
39. Lees C, Valensise H, Black R, et al. The efficacy and fetal-maternal cardiovascular effects of transdermal glyceryl trinitrate in the prophylaxis of preeclampsia and its complications: a randomised double-blind placebocontrolled trial. Ultrasound Obstet Gynecol 1998; 12:334-338. (Pubitemid 28517638)
40. Picciolo C, Roncaglia N, Neri I, et al. Nitric oxide in the prevention of preeclampsia. Prenat Neonat Med 2000; 5:212-215.
41. Davis G, Brown M. Glyceryl trinitrate patches are unsuitable in hypertensive pregnancy. Aust N Z J Obstet Gynaecol 2001; 41:474.
42. Neri I, Valensise H, Facchinetti F, et al. 24-h Ambulatory blood pressure monitoring: a comparison between transdermal glyceryl nitrate and oral nifedipine. Hypertens Pregnancy 1999; 18:107-113. (Pubitemid 29149862)
43. Zozulia OV, Rogov VA, Piatakova NV, Tareeva IE. Nitric oxide: its role in the development of pregnancy complications and in their prevention in women with hypertension and chronic glomerulonephritis. Ter Arkh 1997; 69:17-20. (Pubitemid 127516110)
44. Facchinetti F, Saade GR, Neri I, et al. L-Arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens Pregnancy 2007; 26:121-130. (Pubitemid 46649344)
45. Vadillo-Ortega F, Perichart-Perera O, Espino S, et al. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. Br Med J 2011; 342:d2901.
46. Ramsay B, de Belder A, Campbell S, et al. A nitric oxide donor improves uterine artery diastolic blood flow in normal pregnancy and in women at high risk of preeclampsia. Eur J Clin Invest 1994; 24: 76-78. (Pubitemid 24204959)
47. Grunewald C, Kublickas M, Carlstorm K, et al. Effects of nitroglycerine on the uterine and umbilical circulation in severe preeclampsia. Obstet Gynecol 1995; 86:600-604.