Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta

Experimental and Toxicologic Pathology

Volumn 65, Issue 1-2, 2013, Pages 105-112

  Nitha, B ^a   Fijesh, P V ^a   Janardhanan, K K ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Carbon tetrachloride; Ethanol; Hepatoprotection; Medicinal mushrooms; Morchella esculenta; Mushroom mycelium

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CATALASE; FUNGAL EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIV 52; MALONALDEHYDE; MORCHELLA ESCULENTA EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TOXICITY; MALE; MORCHELLA ESCULENTA; MYCELIUM; NONHUMAN; RAT; TREATMENT OUTCOME;

ANIMALIA; BASIDIOMYCOTA; MORCHELLA ESCULENTA;

EID: 84870247305     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2011.06.007     Document Type: Article

References (50)

1. Ajith T.A., Janardhanan K.K. Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat. J Ethnopharmacol 2002, 81:387-391.
2. Ajith T.A., Sheena N., Janardhanan K.K. Phellinus rimosus protects carbon tetrachloride induced chronic hepatotoxicity in rats: antioxidant defense mechanism. Pharmaceut Biol 2006, 44:467-474.
3. Aruna K., Kalpana C., Viswanathan P., Menon V.P. Toxic effect of sunflower oil on ethanol treated rats. Hepatol Res 2002, 24:125-135.
4. Beer R.F., Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1951, 95:133-140.
5. Bhadauria M., Jadon A., Sharma A., Shukla S. Effect of propriety herbal formulation against chronic carbon tetrachloride induced hepatotoxicity. Indian J Exp Biol 2002, 40:1254-1259.
6. Bonday S.C., Nanderi S. Contribution of hepatic cytochrome P 450 systems to the generation of reactive oxygen species. Biochem Pharmacol 1994, 48:240-254.
7. Bradford M.A. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1970, 72:240-254.
8. 4-induced liver injury in mice and its possible mechanisms. World J Gastroenterol 2005, 11:5795-5800.
9. Comporti M. Lipid peroxidation: an overview. Free radicals: from basic science to medicine: molecular and cell biology updates 1993, 65-79. Birkhauser Verlag, Basel, Switzerland. G. Poli, E. Albano, M.U. Dianzani (Eds.).
10. Coskun O., Yakan B., Oztas E., Sezen S., Gunaydin A. Antioxidant and hepatoprotective activity of Vitamin E and Egb 761 in experimental endotoxemic rats. Int J Med Sci 2000, 30:427-432.
11. Crawford D.W., Balakenhoan D.H. Arterial wall oxygenation oxy radicals and atherosclerosis. Atherosclerosis 1991, 89:97-108.
12. Ekanem E.O., Ubengama V.S. Chemical composition of antinutritional factors and shelf life of Oyster mushroom (Pleurotus ostreatus). J Food Sci Technol 2002, 39:635-638.
13. Gueeri H. Influence on prolonged ethanol intake on the level and turnover of alcohol and aldehyde dehydrogenase and glutathione. Adv Exp Med Biol 1995, 23:12-14.
14. Habig W.H., Pabst M.J., Jakoby W.R. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
15. Hafemann H.G., Sunde R.A., Housestra W.G. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in rat. J Nutr 1974, 104:580-584.
16. Janardhanan K.K., Husain A. Production of morel mushroom mycelium a potential source of protein and flavour. Indian mushroom science I. Today and tomorrow and Indo-American lit 1978, 495-508. House Atal. C.K. Atal, B.K. Bhat, T.N. Kaul (Eds.).
17. Janardhanan K.K., Kaul T.N., Husain A. Use of vegetable waste for the production of fungal protein from Morchella species. J Food Sci Technol 1979, 7:197-199.
18. Jones S., Janardhanan K.K. Antioxidant and antitumor activity of Ganoderma lucidum (Curt: Fr) P. Karst-Reishi (Aphyllophoromycerideae) from South India. Int J Med Mushr 2000, 2:195-200.
19. Jong S.C., Birmingham J.M. Medicinal benefits of the mushroom Ganoderma. Adv Appl Microbiol 1992, 37:101-134.
20. Jose N., Ajith T.A., Janardhanan K.K. Antioxidant, anti-inflammatory and antitumor activities of culinary medicinal mushroom Pleurotus pulmonaris (Fr) Qel (Agaricomycetideae). Int J Med Mushr 2002, 4:329-335.
21. 4 poisoning?. Free Radic Biol Med 2000, 28:838.
22. Kannarkat G.T., Tuma D.J., Tuma P.L. Microtubules are more stable and more highly acetylated in ethanol-treated hepatic cells. J Hepatol 2005, 20:1-8.
23. Kanter M., Coskun O., Budancamnak M. Hepatoprotective effect of Nigella sativa L and Utrica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride treated rats. World J Gastroenterol 2005, 11:6684-6688.
24. Kim J.A., Lau E., Tay D., De Balaco E.J., Antioxidant, NF-kappa B inhibitory constituents isolated from Morchella esculenta. Nat Prod Res 2010, 16:1-6.
25. Kind P.R.N., King E.J. Method of Kind and King. Method of practical and clinical biochemistry 1980, 899-900. Heinemann, London. H. Varley, A.H. Gowenlock, M. Bell (Eds.).
26. Lakshmi B., Tilak J.C., Adhikari S., Devasgayam T.P.A., Janardhanan K.K. Evaluation of antioxidant activity of Indian Mushrooms. Pharmaceut Biol 2004, 42(3):179-185.
27. Lieber C.S. Hepatic metabolism and some toxic effects by ethyl alcohol: 1991, update, alcohol. Clin Exp Res 1991, 15:573-592.
28. Lim H.K., Kim H.S., Choi H.S., Oh S., Choi J. Hepatoprotective effects of bergenen, a major constituent of Mallotus Japonicus, on carbon-tetrachloride-intoxicated rats. J Ethnopharmacol 2000, 72:469.
29. Lin C.C., Yen M.H., Lo T.S., Lin J.M. Evaluation of hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima. J Ethnopharmacol 1997, 60:9-17.
30. Mc Cord J.M., Fridovich I. Superoxide dismutase an enzymatic function for erythrocurprein. J Biol Chem 1969, 244:6049-6055.
31. Menenghini R., Martins E.A., Calderaro M. DNA damage by reactive oxygen species: the role of metal. Free radicals: from basic science to medicine: molecular and cell biology updates 1993, 102-112. Birkhauser Verlag, Basel, Switzerland. G. Poli, E. Albano, M.U. Dianzani (Eds.).
32. Meng F., Zhon B., Liu B., Jia L., Liu X., Deng P., Fan K., Wang G., Wang Z., Zhang J. Extraction, optimization and in vivo antioxidant activity of expolysaccharide by Morchella esculenta. Bioresour Technol 2010, 101:4564-4569.
33. Moron M.A., Depierre J.W., Mannervik B. Levels of Glutathione-S-transferase activities in rat liver lung. Biochim Biophys Acta 1979, 582:67-78.
34. Nitha B., Janardhanan K.K. Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food Chem Toxicol 2008, 46:3193-3199.
35. Nitha B., Meera C.R., Janardhanan K.K. Antiinflammatory and antitumor activities of cultured mycelium of morel mushroom, Morchella esculenta. Curr Sci 2007, 92:235-239.
36. Nitha B., Strayo De, Adhikari S.K., Devasagayam T.P.A., Janardhanan K.K. Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: a potential source of therapeutically useful antioxidants. Pharmaceut Biol 2010, 48(4):453-460.
37. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
38. Poli G. Liver damage due to free radicals. Br Med Bull 1993, 49:604.
39. Prasad P., Chauhan K., Kandari L.S. Morchella esculenta (Guchhi): need for scientific intervention for its cultivation in Central Himalaya. Curr Sci 2002, 82:1098-1100.
40. Rajagopal S.K., Manickam P., Periyasami V., Namasivayam N. Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury. J Nutr Biochem 2003, 14:452-458.
41. Rana S.V.S., Kumar S. Antioxidant enzymes in the liver of rat treated with carbon tetrachloride after parathyroidectomy. Physiol Chem Phys 1993, 25:41-46.
42. Recknagel R.O., Glende E.A., Waller R.L., Loery K. Lipid peroxidation. Biochemistry, measurement and significance in liver cell injury. Toxicology of the liver 1982, 213-241. Raven Press, New York. G.L. Plaa, W.R. Hewitt (Eds.).
43. Reitman S., Frankel S. A calorimetric method for the determination of serum glutamate oxaloacetate and glutamate pyruvate transaminase. Am J Clin Pathol 1957, 28:53-56.
44. Sallie R., Tredger J.M., William R. Drugs and the liver. Biopharm Drug Dispos 1999, 12:251-259.
45. Sandhir R., Gill G.D. Hepatoprotective effects of Liv 52 on ethanol induced liver damage in rats. Indian J Exp Biol 1999, 37:762-766.
46. Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by new colorimetric method. Clin Chim Acta 1987, 90:37-43.
47. Szas G. Reaction rate method for gamma glutamyl transferase activity in serum. Clin Chem 1976, 22:2051-2055.
48. Weisman H., Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory diseases and progression to cancer. Biochem J 1996, 313:17-29.
49. Yoshikawa T., Tanaka H., Yoshida N., Seto O., Sugino N., Kondo M. Adjuent arthritis and lipid peroxide protection by superoxide dismutase. Lipid Peroxide Res 1983, 7:108-110.
50. Yuda Y., Tanaka J., Hirano F., Igarani K., Satch T. Participation of lipid peroxidation in rat pertussis vaccine pleurisy. Chem Pharm Bull 1991, 39:505-506.