Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: Prospective case series

Hypertension

Volumn 60, Issue 6, 2012, Pages 1485-1490

  Brinkmann, Julia ^a   Heusser, Karsten ^a   Schmidt, Bernhard M ^a   Menne, Jan ^a   Klein, Gunnar ^a   Bauersachs, Johann ^a   Haller, Hermann ^a   Sweep, Fred C ^c   Diedrich, Andre ^b   Jordan, Jens ^a   Tank, Jens ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b VANDERBILT UNIVERSITY   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

arterial hypertension; baroreflex; renal nerve ablation; sympathetic nerve traffic

Indexed keywords

ALISKIREN; AMLODIPINE; BISOPROLOL; CANDESARTAN; CHLORTALIDONE; CLONIDINE; DIHYDRALAZINE; EPLERENONE; FOSINOPRIL; GLYCERYL TRINITRATE; HYDROCHLOROTHIAZIDE; IRBESARTAN; LERCANIDIPINE; METOPROLOL; MINOXIDIL; MOXONIDINE; NEBIVOLOL; NIFEDIPINE; OLMESARTAN; RAMIPRIL; SPIRONOLACTONE; TELMISARTAN; TORASEMIDE; URAPIDIL; VALSARTAN;

ABLATION THERAPY; ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE VARIABILITY; BREATHING; CATHETER; CLINICAL ARTICLE; ELECTROCARDIOGRAM; ENDOVASCULAR RENAL NERVE ABLATION; FEMALE; HEART RATE VARIABILITY; HUMAN; HYPERTENSION; MALE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SYMPATHETIC TONE;

AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CATHETER ABLATION; FEMALE; HEART RATE; HUMANS; HYPERTENSION; KIDNEY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SYMPATHECTOMY; SYMPATHETIC NERVOUS SYSTEM; TREATMENT OUTCOME;

EID: 84870245724     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.201186     Document Type: Article

References (35)

1. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M; Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (the Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903-1909.
2. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373:1275-1281.
3. DiBona GF. Neural control of the kidney: past, present, and future. Hypertension. 2003;41(3 pt 2):621-624.
4. DiBona GF, Esler M. Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol. 2010;298:R245-R253.
5. Grimson KS. Total thoracic and partial to total lumbar sympathectomy and celiac ganglionectomy in the treatment of hypertension. Ann Surg. 1941;114:753-775.
6. Gordon RD, Küchel O, Liddle GW, Island DP. Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J Clin Invest. 1967;46:599-605.
7. Biaggioni I, Garcia F, Inagami T, Haile V. Hyporeninemic normoaldosteronism in severe autonomic failure. J Clin Endocrinol Metab. 1993;76:580-586.
8. Bell-Reuss E, Trevino DL, Gottschalk CW. Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption. J Clin Invest. 1976;57:1104-1107.
9. DiBona GF, Sawin LL. Effect of renal nerve stimulation on NaCl and H2O transport in Henle's loop of the rat. Am J Physiol. 1982;243:F576-F580.
10. Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med. 2009;361:932-934.
11. Hausberg M, Kosch M, Harmelink P, Barenbrock M, Hohage H, Kisters K, Dietl KH, Rahn KH. Sympathetic nerve activity in end-stage renal disease. Circulation. 2002;106:1974-1979.
12. Ye S, Gamburd M, Mozayeni P, Koss M, Campese VM. A limited renal injury may cause a permanent form of neurogenic hypertension. Am J Hypertens. 1998;11(6 pt 1):723-728.
13. Ye S, Zhong H, Yanamadala S, Campese VM. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension. 2006;48:309-315.
14. Willemsen JJ, Ross HA, Jacobs MC, Lenders JW, Thien T, Swinkels LM, Benraad TJ. Highly sensitive and specific HPLC with fluorometric detection for determination of plasma epinephrine and norepinephrine applied to kinetic studies in humans. Clin Chem. 1995;41:1455-1460.
15. Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. α-2 adrenergic transmission and human baroreflex regulation. Hypertension. 2004;43:1035-1041.
16. Bertinieri G, di Rienzo M, Cavallazzi A, Ferrari AU, Pedotti A, Mancia G. A new approach to analysis of the arterial baroreflex. J Hypertens Suppl. 1985;3:S79-S81.
17. Sleight P, Floras JS, Hassan MO, Jones JV, Osikowska BA, Sever P, Turner KL. Baroreflex control of blood pressure and plasma noradrenaline during exercise in essential hypertension. Clin Sci (Lond). 1979;57(suppl 5):169s-171s.
18. Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity. Circ Res. 1969;24:109-121.
19. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension. 2004;43:1042-1047.
20. Esler M, Lambert E, Schlaich M. Point: chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension. J Appl Physiol. 2010;109:1996-1998 .
21. Kubo T, Azevedo ER, Newton GE, Picton P, Parker JD, Floras JS. β-Blockade restores muscle sympathetic rhythmicity in human heart failure. Circ J. 2011;75:1400-1408.
22. Tank J, Biller H, Heusser K, Holz O, Diedrich A, Framke T, Koch A, Grosshennig A, Koch W, Krug N, Jordan J, Hohlfeld JM. Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: a randomized, placebo controlled, crossover study. PLoS ONE. 2011;6:e18737.
23. Fagius J, Wallin BG. Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res. 1993;3:201-205.
24. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 1986;59:178-193.
25. Goldstein DS, Bentho O, Park MY, Sharabi Y. Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes. Exp Physiol. 2011;96:1255-1261.
26. Eckberg DL. Sympathovagal balance: a critical appraisal. Circulation. 1997;96:3224-3232.
27. Rippy MK, Zarins D, Barman NC, Wu A, Duncan KL, Zarins CK. Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. Clin Res Cardiol. 2011;100:1095-1101.
28. Gazdar AF, Dammin GJ. Neural degeneration and regeneration in human renal transplants. N Engl J Med. 1970;283:222-224.
29. Ditting T, Freisinger W, Siegel K, Fiedler C, Small L, Neuhuber W, Heinlein S, Reeh PW, Schmieder RE, Veelken R. Tonic postganglionic sympathetic inhibition induced by afferent renal nerves? Hypertension. 2012;59:467-476.
30. Jordan J, Tank J, Hohenbleicher H, Toka H, Schröder C, Sharma AM, Luft FC. Heterogeneity of autonomic regulation in hypertension and neurovascular contact. J Hypertens. 2002;20:701-706.*These authors contributed equally to this article.
31. Fu Q, Zhang R, Witkowski S, Arbab-Zadeh A, Prasad A, Okazaki K, Levine BD. Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity? Hypertension. 2005;45:513-521.
32. Cuspidi C, Macca G, Sampieri L, Michev I, Salerno M, Fusi V, Severgnini B, Meani S, Magrini F, Zanchetti A. High prevalence of cardiac and extracardiac target organ damage in refractory hypertension. J Hypertens. 2001;19:2063-2070.
33. Bobrie G, Frank M, Azizi M, Peyrard S, Boutouyrie P, Chatellier G, Laurent S, Menard J, Plouin PF. Sequential nephron blockade versus sequential renin-angiotensin system blockade in resistant hypertension: a prospective, randomized, open blinded endpoint study. J Hypertens. 2012;30:1656-1664.
34. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, O'Connor PJ, Selby JV, Ho PM. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125:1635-1642.
35. Dimeo F, Pagonas N, Seibert F, Arndt R, Zidek W, Westhoff TH. Aerobic exercise reduces blood pressure in resistant hypertension. Hypertension. 2012;60:653-658.