Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation

Journal of Controlled Release

Volumn 164, Issue 3, 2012, Pages 364-369

  Gaillard, Pieter J ^a   Appeldoorn, Chantal C M ^a   Rip, Jaap ^a   Dorland, Rick ^a   Van Der Pol, Susanne M A ^b   Kooij, Gijs ^b   De Vries, Helga E ^b   Reijerkerk, Arie ^b  

^a To BBB Technologies BV   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Blood brain barrier; Brain drug targeting; Drug delivery; Multiple sclerosis; Neuroinflammation

Indexed keywords

ANIMAL MODEL; ANTI-INFLAMMATORY DRUGS; BLOOD-BRAIN BARRIER; BRAIN DELIVERY; BRAIN UPTAKE; CENTRAL NERVOUS SYSTEMS; CLINICAL SIGNS; DRUG-TARGETING; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GLUCOCORTICOIDS; GLUTATHIONES; MULTIPLE SCLEROSIS; NEUROINFLAMMATION; NON-TARGETED; PEGYLATED LIPOSOMES; SALINE CONTROL; SIDE EFFECT; THERAPEUTIC EFFICACY;

DISEASE CONTROL; DRUG DELIVERY; DRUG INTERACTIONS; LIPOSOMES; PEPTIDES; RATS;

DISEASES;

GLUTATHIONE; LIPOSOME; METHYLPREDNISOLONE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CIRCULATION TIME; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; MALE; MULTIPLE SCLEROSIS; NANOENCAPSULATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; DRUG CARRIERS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GLUTATHIONE; LIPOSOMES; MALE; METHYLPREDNISOLONE; POLYETHYLENE GLYCOLS; RATS; RATS, INBRED LEW; TISSUE DISTRIBUTION;

EID: 84870235701     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.022     Document Type: Conference Paper

References (29)

1. B.V. Zlokovic New therapeutic targets in the neurovascular pathway in Alzheimer's disease Neurotherapeutics 5 3 2008 409 414
2. V. Wee Yong Inflammation in neurological disorders: a help or a hindrance? Neuroscientist 16 4 2010 408 420
3. R. Vosoughi, and M.S. Freedman Therapy of MS Clin. Neurol. Neurosurg. 112 5 2010 365 385
4. H.M. Reichardt, R. Gold, and F. Luhder Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis Expert Rev. Neurother. 6 11 2006 1657 1670
5. S. Floris, E.L. Blezer, G. Schreibelt, E. Dopp, S.M. van der Pol, I.L. Schadee-Eestermans, K. Nicolay, C.D. Dijkstra, and H.E. de Vries Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study Brain 127 Pt 3 2004 616 627
6. R. Gold, C. Linington, and H. Lassmann Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research Brain 129 Pt 8 2006 1953 1971
7. G.D. Kanmogne, C. Primeaux, and P. Grammas HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia J. Neuropathol. Exp. Neurol. 64 6 2005 498 505
8. K. Dinkel, W.O. Ogle, and R.M. Sapolsky Glucocorticoids and central nervous system inflammation J. Neurovirol. 8 6 2002 513 528
9. M.T. Fitch, and D. van de Beek Drug Insight: steroids in CNS infectious diseases - new indications for an old therapy Nat. Clin. Pract. Neurol. 4 2 2008 97 104
10. D. Tischner, and H.M. Reichardt Glucocorticoids in the control of neuroinflammation Mol. Cell. Endocrinol. 275 1-2 2007 62 70
11. R.A. Linker, C. Weller, F. Luhder, A. Mohr, J. Schmidt, M. Knauth, J.M. Metselaar, and R. Gold Liposomal glucocorticosteroids in treatment of chronic autoimmune demyelination: long-term protective effects and enhanced efficacy of methylprednisolone formulations Exp. Neurol. 211 2 2008 397 406
12. J.M. Metselaar, W.B. van den Berg, A.E. Holthuysen, M.H. Wauben, G. Storm, and P.L. van Lent Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis Ann. Rheum. Dis. 63 4 2004 348 353
13. J.M. Metselaar, M.H. Wauben, J.P. Wagenaar-Hilbers, O.C. Boerman, and G. Storm Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes Arthritis Rheum. 48 7 2003 2059 2066
14. U. Rauchhaus, R.W. Kinne, D. Pohlers, S. Wiegand, A. Wolfert, M. Gajda, R. Brauer, and S. Panzner Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis Ann. Rheum. Dis. 68 12 2009 1933 1934
15. J. Schmidt, J.M. Metselaar, M.H. Wauben, K.V. Toyka, G. Storm, and R. Gold Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis Brain 126 Pt 8 2003 1895 1904
16. J.M. van den Hoven, W. Hofkens, M.H. Wauben, J.P. Wagenaar-Hilbers, J.H. Beijnen, B. Nuijen, J.M. Metselaar, and G. Storm Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis Int. J. Pharm. 416 2 2011 471 477
17. B.J. Crielaard, T. Lammers, M.E. Morgan, L. Chaabane, S. Carboni, B. Greco, P. Zaratin, A.D. Kraneveld, and G. Storm Macrophages and liposomes in inflammatory disease: friends or foes? Int. J. Pharm. 416 2 2011 499 506
18. Y. Avnir, R. Ulmansky, V. Wasserman, S. Even-Chen, M. Broyer, Y. Barenholz, and Y. Naparstek Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: a novel approach to treating autoimmune arthritis Arthritis Rheum. 58 1 2008 119 129
19. P.J. Gaillard, C.C. Visser, C.C.M. Appeldoorn, and J. Rip Enhanced brain drug delivery: safely crossing the blood-brain barrier Drug Discov. Today Tech. 2011 10.1016/j.ddtec.2011.12.002
20. P.J. Gaillard Crossing barriers from blood-to-brain and academia-to-industry Ther. Deliv. 1 4 2010 495 500
21. R. Kannan, R. Chakrabarti, D. Tang, K.J. Kim, and N. Kaplowitz GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC Brain Res. 852 2 2000 374 382
22. R. Kannan, J.F. Kuhlenkamp, E. Jeandidier, H. Trinh, M. Ookhtens, and N. Kaplowitz Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat J. Clin. Invest. 85 6 1990 2009 2013
23. B.V. Zlokovic, J.B. Mackic, J.G. McComb, M.H. Weiss, N. Kaplowitz, and R. Kannan Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem. Biophys. Res. Commun. 201 1 1994 402 408
24. J. Rip, C.C.M. Appeldoorn, F.M. Manca, R. Dorland, J.M.R. van Kregten, and P.J. Gaillard Receptor-mediated delivery of drugs across the blood-brain barrier Front. Pharmacol. Conference Abstract (2010): Pharmacology and Toxicology of the Blood-brain Barrier: State of the Art, Needs for Future Research and Expected Benefits for the EU 2010 10.3389/conf.fphar.2010.02.00025
25. P.J. Gaillard, W. Gladdines, C.C.M. Appeldoorn, J. Rip, W.J. Boogerd, J.H. Beijnen, D. Brandsma, and O. van Tellingen Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer [abstract] Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research 2012 AACR Chicago, Illinois Philadelphia (PA), Abstract nr 5687
26. G. Kooij, J. van Horssen, E.C. de Lange, A. Reijerkerk, S.M. van der Pol, B. van Het Hof, J. Drexhage, A. Vennegoor, J. Killestein, G. Scheffer, R. Oerlemans, R. Scheper, P. van der Valk, C.D. Dijkstra, and H.E. de Vries T lymphocytes impair P-glycoprotein function during neuroinflammation J. Autoimmun. 34 4 2010 416 425
27. G. Schreibelt, R.J. Musters, A. Reijerkerk, L.R. de Groot, S.M. van der Pol, E.M. Hendrikx, E.D. Dopp, C.D. Dijkstra, B. Drukarch, and H.E. de Vries Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity J. Immunol. 177 4 2006 2630 2637
28. N. Schweingruber, A. Haine, K. Tiede, A. Karabinskaya, J. van den Brandt, S. Wust, J.M. Metselaar, R. Gold, J.P. Tuckermann, H.M. Reichardt, and F. Luhder Liposomal encapsualtion of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis J. Immunol. 187 8 2011 4310 4318
29. E. Polazzi, and B. Monti Microglia and neuroprotection: from in vitro studies to therapeutic applications Prog. Neurobiol. 92 3 2010 293 315