Comparative outcomes of rectal cancer surgery between elderly and non-elderly patients: A systematic review

The Lancet Oncology

Volumn 13, Issue 12, 2012, Pages

  Manceau, Gilles ^a   Karoui, Mehdi ^a   Werner, Andrew ^b   Mortensen, Neil J ^c   Hannoun, Laurent ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; CANCER SURGERY; CANCER SURVIVAL; CASE CONTROL STUDY; COHORT ANALYSIS; COMPARATIVE STUDY; HUMAN; LAPAROSCOPY; LAPAROTOMY; MEDICAL DECISION MAKING; MORBIDITY; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUALITY OF LIFE; RECTUM CANCER; RETROSPECTIVE STUDY; REVIEW; SPHINCTER; SURGICAL APPROACH; SYSTEMATIC REVIEW;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANASTOMOTIC LEAK; HUMANS; LAPAROSCOPY; POSTOPERATIVE COMPLICATIONS; QUALITY OF LIFE; RECTAL NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84870231295     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(12)70378-9     Document Type: Review

References (81)

1. Rutten HJ, den Dulk M, Lemmens VE, van de Velde CJ, Marijnen CA Controversies of total mesorectal excision for rectal cancer in elderly patients. Lancet Oncol 2008, 9:494-501.
2. Jung B, Pahlman L, Johansson R, Nilsson E Rectal cancer treatment and outcome in the elderly: an audit based on the Swedish Rectal Cancer Registry 1995-2004. BMC Cancer 2009, 9:68.
3. Elferink MA, Krijnen P, Wouters MW, et al. Variation in treatment and outcome of patients with rectal cancer by region, hospital type and volume in the Netherlands. Eur J Surg Oncol 2010, 36(suppl 1):S74-S82.
4. Bouvier AM, Launoy G, Lepage C, Faivre J Trends in the management and survival of digestive tract cancers among patients aged over 80 years. Aliment Pharmacol Ther 2005, 22:233-241.
5. Lemmens VE, Janssen-Heijnen ML, Verheij CD, Houterman S, Repelaer van Driel OJ, Coebergh JW Co-morbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer. Br J Surg 2005, 92:615-623.
6. Shahir MA, Lemmens VE, van de Poll-Franse LV, Voogd AC, Martijn H, Janssen-Heijnen ML Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: a population-based study. Eur J Cancer 2006, 42:3015-3021.
7. Chang GJ, Skibber JM, Feig BW, Rodriguez-Bigas M Are we undertreating rectal cancer in the elderly? An epidemiologic study. Ann Surg 2007, 246:215-221.
8. Endreseth BH, Romundstad P, Myrvold HE, Bjerkeset T, Wibe A Rectal cancer treatment of the elderly. Colorectal Dis 2006, 8:471-479.
9. Vironen JH, Sainio P, Husa AI, Kellokumpu IH Complications and survival after surgery for rectal cancer in patients younger than and aged 75 years or older. Dis Colon Rectum 2004, 47:1225-1231.
10. Esnaola NF, Stewart AK, Feig BW, Skibber JM, Rodriguez-Bigas MA Age-, race-, and ethnicity-related differences in the treatment of nonmetastatic rectal cancer: a patterns of care study from the national cancer data base. Ann Surg Oncol 2008, 15:3036-3047.
11. Kessler H, Hermanek P, Wiebelt H Operative mortality in carcinoma of the rectum. Results of the German Multicentre Study. Int J Colorectal Dis 1993, 8:158-166.
12. Barrier A, Ferro L, Houry S, Lacaine F, Huguier M Rectal cancer surgery in patients more than 80 years of age. Am J Surg 2003, 185:54-57.
13. Tan E, Tilney H, Thompson M, Smith J, Tekkis PP The United Kingdom National Bowel Cancer Project - epidemiology and surgical risk in the elderly. Eur J Cancer 2007, 43:2285-2294.
14. Eldin NS, Yasui Y, Scarfe A, Winget M Adherence to treatment guidelines in stage II/III rectal cancer in Alberta, Canada. Clin Oncol (R Coll Radiol) 2012, 24:e9-e17.
15. Puig-La Calle J, Quayle J, Thaler HT, et al. Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older. Dis Colon Rectum 2000, 43:1704-1709.
16. Smith JJ, Lee J, Burke C, Contractor KB, Dawson PM Major colorectal cancer resection should not be denied to the elderly. Eur J Surg Oncol 2002, 28:661-666.
17. Rutten H, den Dulk M, Lemmens V, et al. Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery. Eur J Cancer 2007, 43:2295-2300.
18. Law WL, Choi HK, Ho JW, Lee YM, Seto CL Outcomes of surgery for mid and distal rectal cancer in the elderly. World J Surg 2006, 30:598-604.
19. Townsley CA, Selby R, Siu LL Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. J Clin Oncol 2005, 23:3112-3124.
20. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004, 351:1731-1740.
21. Gerard JP, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006, 24:4620-4625.
22. Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2008, 149:627-637. U.S. Preventive Services Task Force.
23. Andereggen E, Ris F, Gervaz P, Bucher P, Morel P Outcome of surgery for rectal cancer in octogenarians. Swiss Med Wkly 2006, 136:185-188.
24. Holm T, Rutqvist LE, Johansson H, Cedermark B Postoperative mortality in rectal cancer treated with or without preoperative radiotherapy: causes and risk factors. Br J Surg 1996, 83:964-968.
25. Alves A, Panis Y, Mathieu P, Kwiatkowski F, Slim K, Mantion G Mortality and morbidity after surgery of mid and low rectal cancer. Results of a French prospective multicentric study. Gastroenterol Clin Biol 2005, 29:509-514.
26. Hotta T, Takifuji K, Yokoyama S, et al. Rectal cancer surgery in the elderly: analysis of consecutive 158 patients with stage III rectal cancer. Langenbeck Arch Surg 2007, 392:549-558.
27. Matthiessen P, Hallbook O, Andersson M, Rutegard J, Sjodahl R Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 2004, 6:462-469.
28. Eriksen MT, Wibe A, Norstein J, Haffner J, Wiig JN Anastomotic leakage following routine mesorectal excision for rectal cancer in a national cohort of patients. Colorectal Dis 2005, 7:51-57.
29. Peeters KC, Tollenaar RA, Marijnen CA, et al. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg 2005, 92:211-216.
30. Lin JK, Yueh TC, Chang SC, et al. The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer. J Gastrointest Surg 2011, 15:2251-2261.
31. Marusch F, Koch A, Schmidt U, et al. The impact of the risk factor "age" on the early postoperative results of surgery for colorectal carcinoma and its significance for perioperative management. World J Surg 2005, 29:1013-1021.
32. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001, 345:638-646.
33. Mollen RM, Damhuis RA, Coebergh JW Local recurrence and survival in patients with rectal cancer, diagnosed 1981-86: a community hospital-based study in the south-east Netherlands. Eur J Surg Oncol 1997, 23:20-23.
34. Damhuis RA, Wiggers T, Wereldsma JC Association between age and local recurrence of rectal cancer: results from a retrospective study of 902 patients. Int J Colorectal Dis 1997, 12:235-239.
35. Dekker JW, van den Broek CB, Bastiaannet E, van de Geest LG, Tollenaar RA, Liefers GJ Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients. Ann Surg Oncol 2011, 18:1533-1539.
36. Kiran RP, Pokala N, Dudrick SJ Long-term outcome after operative intervention for rectal cancer in patients aged over 80 years: analysis of 9,501 patients. Dis Colon Rectum 2007, 50:604-610.
37. Nedrebo BS, Soreide K, Eriksen MT, et al. Survival effect of implementing national treatment strategies for curatively resected colonic and rectal cancer. Br J Surg 2011, 98:716-723.
38. Liu L, Cao Y, Zhang G, Zhang L, Wang P, Gong J Long-term outcomes after laparoscopic total mesorectal excision for advanced rectal cancer. S Afr J Surg 2011, 49:186-189.
39. Engel J, Kerr J, Schlesinger-Raab A, Eckel R, Sauer H, Holzel D Quality of life in rectal cancer patients: a four-year prospective study. Ann Surg 2003, 238:203-213.
40. Rauch P, Miny J, Conroy T, Neyton L, Guillemin F Quality of life among disease-free survivors of rectal cancer. J Clin Oncol 2004, 22:354-360.
41. Sideris L, Zenasni F, Vernerey D, et al. Quality of life of patients operated on for low rectal cancer: impact of the type of surgery and patients' characteristics. Dis Colon Rectum 2005, 48:2180-2191.
42. Hendren SK, O'Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg 2005, 242:212-223.
43. Schmidt CE, Bestmann B, Kuchler T, Kremer B Factors influencing sexual function in patients with rectal cancer. Int J Impot Res 2005, 17:231-238.
44. Schmidt CE, Bestmann B, Kuchler T, Longo WE, Kremer B Impact of age on quality of life in patients with rectal cancer. World J Surg 2005, 29:190-197.
45. Pucciarelli S, Del Bianco P, Toppan P, et al. Health-related quality of life outcomes in disease-free survivors of mid-low rectal cancer after curative surgery. Ann Surg Oncol 2008, 15:1846-1854.
46. den Dulk M, Smit M, Peeters KC, et al. A multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study. Lancet Oncol 2007, 8:297-303.
47. David GG, Slavin JP, Willmott S, Corless DJ, Khan AU, Selvasekar CR Loop ileostomy following anterior resection: is it really temporary?. Colorectal Dis 2010, 12:428-432.
48. Lindgren R, Hallbook O, Rutegard J, Sjodahl R, Matthiessen P What is the risk for a permanent stoma after low anterior resection of the rectum for cancer? A six-year follow-up of a multicenter trial. Dis Colon Rectum 2011, 54:41-47.
49. Junginger T, Gonner U, Trinh TT, Lollert A, Oberholzer K, Berres M Permanent stoma after low anterior resection for rectal cancer. Dis Colon Rectum 2010, 53:1632-1639.
50. Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg 2007, 246:207-214.
51. Dehni N, Schlegel D, Tiret E, Singland JD, Guiguet M, Parc R Effects of aging on the functional outcome of coloanal anastomosis with colonic J-pouch. Am J Surg 1998, 175:209-212.
52. Phillips PS, Farquharson SM, Sexton R, Heald RJ, Moran BJ Rectal cancer in the elderly: patients' perception of bowel control after restorative surgery. Dis Colon Rectum 2004, 47:287-290.
53. Hida J, Yoshifuji T, Tokoro T, et al. Long-term functional outcome of low anterior resection with colonic J-pouch reconstruction for rectal cancer in the elderly. Dis Colon Rectum 2004, 47:1448-1454.
54. Ito M, Saito N, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer. Dis Colon Rectum 2009, 52:64-70.
55. Olagne E, Baulieux J, de la Roche E, et al. Functional results of delayed coloanal anastomosis after preoperative radiotherapy for lower third rectal cancer. J Am Coll Surg 2000, 191:643-649.
56. Krouse RS, Herrinton LJ, Grant M, et al. Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex. J Clin Oncol 2009, 27:4664-4670.
57. Scheidbach H, Schneider C, Hugel O, Yildirim C, Lippert H, Kockerling F Laparoscopic surgery in the old patient: do indications and outcomes differ?. Langenbeck Arch Surg 2005, 390:328-332.
58. Chautard J, Alves A, Zalinski S, Bretagnol F, Valleur P, Panis Y Laparoscopic colorectal surgery in elderly patients: a matched case-control study in 178 patients. J Am Coll Surg 2008, 206:255-260.
59. Akiyoshi T, Kuroyanagi H, Oya M, et al. Short-term outcomes of laparoscopic rectal surgery for primary rectal cancer in elderly patients: is it safe and beneficial?. J Gastrointest Surg 2009, 13:1614-1618.
60. Kang SB, Park JW, Jeong SY, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol 2010, 11:637-645.
61. Extermann M, Aapro M, Bernabei R, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hemat 2005, 55:241-252.
62. Audisio RA, Pope D, Ramesh HS, et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study. Crit Rev Oncol Hematol 2008, 65:156-163.
63. Papamichael D, Audisio R, Horiot JC, et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol 2009, 20:5-16.
64. Heriot AG, Tekkis PP, Smith JJ, et al. Prediction of postoperative mortality in elderly patients with colorectal cancer. Dis Colon Rectum 2006, 49:816-824.
65. Ramesh HS, Pope D, Gennari R, Audisio RA Optimising surgical management of elderly cancer patients. World J Surg Oncol 2005, 3:17.
66. Fang W, Igaki H, Tachimori Y, Sato H, Daiko H, Kato H Three-field lymph node dissection for esophageal cancer in elderly patients over 70 years of age. Ann Thorac Surg 2001, 72:867-871.
67. Hsu JT, Liu MS, Wang F, et al. Standard radical gastrectomy in octogenarians and nonagenarians with gastric cancer: are short-term surgical results and long-term survival substantial?. J Gastrointest Surg 2012, 16:728-737.
68. Whitehead WE, Borrud L, Goode PS, et al. Fecal incontinence in US adults: epidemiology and risk factors. Gastroenterology 2009, 137:512-517.
69. Higgins PD, Johanson JF Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004, 99:750-759.
70. Lee KF Patient preference and outcomes-based surgical care among octogenarians and nonagenarians. J Am Coll Surg 2006, 202:356-372.
71. Cornish JA, Tilney HS, Heriot AG, Lavery IC, Fazio VW, Tekkis PP A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer. Ann Surg Oncol 2007, 14:2056-2068.
72. Pachler J, Wille-Jorgensen P Quality of life after rectal resection for cancer, with or without permanent colostomy. Cochrane Database Syst Rev 2005, 2. CD004323.
73. Kasparek MS, Hassan I, Cima RR, Larson DR, Gullerud RE, Wolff BG Quality of life after rectal excision and coloanal anastomosis for distal rectal cancers: sphincter preservation versus quality of life. Colorectal Dis 2011, 13:872-877.
74. Jarry J, Faucheron JL, Moreno W, Bellera CA, Evrard S Delayed colo-anal anastomosis is an alternative to prophylactic diverting stoma after total mesorectal excision for middle and low rectal carcinomas. Eur J Surg Oncol 2011, 37:127-133.
75. Schwenk W, Bohm B, Witt C, Junghans T, Grundel K, Muller JM Pulmonary function following laparoscopic or conventional colorectal resection: a randomized controlled evaluation. Arch Surg 1999, 134:6-12.
76. Abraham NS, Young JM, Solomon MJ Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer. Br J Surg 2004, 91:1111-1124.
77. Veldkamp R, Kuhry E, Hop WC, et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 2005, 6:477-484.
78. A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004, 350:2050-2059. The Clinical Outcomes of Surgical Therapy Study Group.
79. Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005, 365:1718-1726.
80. Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg 2010, 97:1638-1645.
81. Huang MJ, Liang JL, Wang H, Kang L, Deng YH, Wang JP Laparoscopic-assisted versus open surgery for rectal cancer: a meta-analysis of randomized controlled trials on oncologic adequacy of resection and long-term oncologic outcomes. Int J Colorectal Dis 2011, 26:415-421.