Histrionicotoxin alkaloids finally detected in an ant

Journal of Natural Products

Volumn 75, Issue 11, 2012, Pages 1930-1936

  Jones, Tappey H ^a   Adams, Rachelle M M ^b   Spande, Thomas F ^c   Garraffo, H Martin ^c   Kaneko, Tetsuo ^c   Schultz, Ted R ^d  

^a VIRGINIA MILITARY INSTITUTE   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d SMITHSONIAN INSTITUTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; DECAHYDROQUINOLINE DERIVATIVE; HISTRIONICOTOXIN;

ANT; ANURA; ARTICLE; CAREBARELLA BICOLOR; CONTROLLED STUDY; COSTA RICA; NONHUMAN; OOPHAGA GRANULIFERA; PANAMA; SOLENOPSIS;

EID: 84870214311     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np300485v     Document Type: Article

References (26)

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15. Daly, J. W.; Highet, R. J.; Myers, C. W. Toxicon 1984, 22, 905-919. A single specimen of this frog was supplied by a commercial dealer and was identified by C. W. Myers at the AMNH, where a voucher is kept. Myers was familiar in 1984 also with M. aurantiaca. A misidentification or the frog being raised outside of Madagascar was proposed by a reviewer to explain this one-time finding of histrionicotoxins in a mantellid. A misidentification seems unlikely in view of the expertise of Myers, and the source being a commercial dealer makes it unlikely we will ever know the relevant history of that one specimen. It could well have been raised outside of Madagascar. John Daly in The Alkaloids, Vol. 43; Cordell, G. A., Ed.; Academic Press: New York, 1993; p 206, pointed out that HTXs had never been found as a skin alkaloid in dozens of collections of many mantellid species that we and others had made over the years. The pet trade sample implies however that an uptake mechanism for HTXs does exist in mantellids as a reviewer notes.
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21. 19 HTXs found in frogs (285E and 287B are the only known HTXs not present) diminishes the likely generality of such a proposal. Our finding that collections of Dendrobates auratus differed in HTXs certainly does indicate ant species having a variety of HTXs are being consumed as prey. These collections in Panama and Costa Rica had two to four HTXs(13) (see text)
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