Q fever: Single-point source outbreak with high attack rates and massive numbers of undetected infections across an entire region

Clinical Infectious Diseases

Volumn 55, Issue 12, 2012, Pages 1591-1599

  Hackert, Volker H ^a,b   Van Der Hoek, Wim ^c   Dukers Muijrers, Nicole ^a,b   De Bruin, Arnout ^c   Al Dahouk, Sascha ^d,e   Neubauer, Heinrich ^f   Bruggeman, Cathrien A ^b   Hoebe, Christian J P A ^a,b  

^a South Limburg Public Health Service   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^f FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; AEROSOL; AGRICULTURAL WORKER; ANTIBODY TITER; ARTICLE; BACTERIAL LOAD; BIOLOGICAL WARFARE; CASE STUDY; COXIELLA BURNETII; DISEASE TRANSMISSION; EPIDEMIC; FEMALE; GEOGRAPHIC INFORMATION SYSTEM; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PUBLIC HEALTH; Q FEVER; QUASI EXPERIMENTAL STUDY; RISK ASSESSMENT; SEROLOGY; SEROPREVALENCE;

ADULT; AGED; AGRICULTURE; ANIMALS; ANTIBODIES, BACTERIAL; CONTACT TRACING; COXIELLA BURNETII; DISEASE OUTBREAKS; FEMALE; GOAT DISEASES; GOATS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NETHERLANDS; PREGNANCY; Q FEVER; SHEEP; SHEEP DISEASES; ZOONOSES;

EID: 84870196826     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis734     Document Type: Article

References (29)

1. Parker NR, Barralet JH, Bell AM. Q fever. Lancet 2006; 367:679-88.
2. Cutler SJ, Bouzid M, Cutler RR. Q fever. J Infect 2007; 54:313-8. (Pubitemid 46401684)
3. Maurin M, Raoult D. Q fever. Clin Microbiol Rev 1999; 12:518-53. (Pubitemid 29484745)
4. Madariaga MG, Rezai K, Trenholme GM, Weinstein RA. Q fever: A biological weapon in your backyard. Lancet Infect Dis 2003; 3:709-21. (Pubitemid 37345350)
5. Roest HI, Tilburg JJ, van der Hoek W, et al. The Q fever epidemic in the Netherlands: History, onset, response and reflection. Epidemiol Infect 2010; 139:1-12.
6. Karagiannis I, Schimmer B, Van Lier A, et al. Investigation of a Q fever outbreak in a rural area of the Netherlands. Epidemiol Infect 2009; 137:1283-94.
7. Schimmer B, Ter Schegget R, Wegdam M, et al. The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak. BMC Infect Dis 2010; 10:69.
8. Roest HI, Ruuls RC, Tilburg JJ, et al. Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands. Emerg Infect Dis 2011; 17:668-75.
9. Eilers PH, Marx BD. Flexible smoothing with B-splines and penalties. Statistical Science 1996; 11:89-121.
10. Schneeberger PM, Hermans MH, van Hannen EJ, Schellekens JJ, Leenders AC, Wever PC. Real-Time PCR with serum samples is indispensable for early diagnosis of acute Q fever. Clin Vaccine Immunol 2010; 17:286-90.
11. Klee SR, Tyczka J, Ellerbrok H, et al. Highly sensitive real-Time PCR for specific detection and quantification of Coxiella burnetii. BMC Microbiol 2006; 6:2.
12. Hawker JI, Ayres JG, Blair I, et al. A large outbreak of Q fever in the West Midlands: Windborne spread into a metropolitan area?. Commun Dis Public Health 1998; 1:180-7.
13. Amitai Z, Bromberg M, Bernstein M, et al. A large Q fever outbreak in an urban school in central Israel. Clin Infect Dis 2010; 50:1433-8.
14. Tissot-Dupont H, Amadei MA, Nezri M, Raoult D. A pedagogical farm as a source of Q fever in a French city. Eur J Epidemiol 2005; 20:957-61.
15. Koene RP, Schimmer B, Rensen H, et al. A Q fever outbreak in a psychiatric care institution in the Netherlands. Epidemiol Infect 2011; 139:13-8.
16. Porten K, Rissland J, Tigges A, et al. A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany. BMC Infect Dis 2006; 6:147.
17. Lyytikainen O, Ziese T, Schwartlander B, et al. An outbreak of sheepassociated Q fever in a rural community in Germany. Eur J Epidemiol 1998; 14:193-9. (Pubitemid 28138918)
18. Carrieri MP, Tissot-Dupont H, Rey D, et al. Investigation of a slaughterhouse-related outbreak of Q fever in the French Alps. Eur J Clin Microbiol Infect Dis 2002; 21:17-21.
19. Lyytikainen O, Ziese T, Schwartlander B, et al. Outbreak of Q fever in Lohra-Rollshausen, Germany, spring 1996. Euro Surveill 1997; 2:9-11.
20. Wallensten A, Moore P, Webster H, et al. Q fever outbreak in Cheltenham, United Kingdom, in 2007 and the use of dispersion modelling to investigate the possibility of airborne spread. Euro Surveill 2010; 15:16-22.
21. Brouqui P, Badiaga S, Raoult D. Q fever outbreak in homeless shelter. Emerg Infect Dis 2004; 10:1297-9. (Pubitemid 38890944)
22. van Woerden HC, Mason BW, Nehaul LK, et al. Q fever outbreak in industrial setting. Emerg Infect Dis 2004; 10:1282-9. (Pubitemid 38890941)
23. Gilsdorf A, Kroh C, Grimm S, Jensen E, Wagner-Wiening C, Alpers K. Large Q fever outbreak due to sheep farming near residential areas, Germany, 2005. Epidemiol Infect 2008; 136:1084-7. (Pubitemid 351982929)
24. de Bruin A, van der Plaats RQ, de Heer L, et al. Detection of Coxiella burnetii DNA on small ruminant farms during a Q fever outbreak in the Netherlands. Appl Environ Microbiol 2012; 78:1652-7.
25. Meekelenkamp JC, Schneeberger PM, Wever PC, Leenders AC. Comparison of ELISA and indirect immunofluorescent antibody assay detecting Coxiella burnetii IgM phase II for the diagnosis of acute Q fever. Eur J Clin Microbiol Infect Dis 2012; 31:1267-70.
26. Jager MM, Weers-Pothoff G, Hermans MH, et al. Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting. Clin Vaccine Immunol 2011; 18:963-8.
27. van der Hoek W, Hogema B, Dijkstra F, et al. Relation between Q fever notifications and Coxiella burnetii infections during the 2009 outbreak in the Netherlands. Euro Surveill 2012; 17:11-5.
28. van der Hoek W, Hunink J, Vellema P. Q fever in the Netherlands: The role of local environmental conditions. Int J Environ Health Res 2011; 21:441-51.
29. Rachael M, Jones MN, Hubbard AE, Reingold AL. The infectious dose of Coxiella burnetii (Q fever). Applied Biosafety 2006; 11:32-41.