A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 40, Issue 1, 2013, Pages 347-352

  Supriyanto, Irwan ^a   Watanabe, Yuichiro ^b   Mouri, Kentaro ^a   Shiroiwa, Kyoichi ^a   Ratta Apha, Woraphat ^a   Yoshida, Masakuni ^a   Tamiya, Genki ^a   Sasada, Toru ^a   Eguchi, Noriomi ^a   Okazaki, Kenji ^a   Shirakawa, Osamu ^c   Someya, Toshiyuki ^b   Hishimoto, Akitoyo ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Association study; Cell adhesion molecules; Integrin; Neurofascin; Schizophrenia

Indexed keywords

CELL ADHESION MOLECULE;

ADULT; ARTICLE; CAM GENE; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; ITGA8 GENE; JAPANESE; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NFASC GENE; PILOT STUDY; SCHIZOPHRENIA; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CELL ADHESION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTEGRIN ALPHA CHAINS; JAPAN; MALE; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SEX FACTORS;

EID: 84870187217     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.11.002     Document Type: Article

References (41)

1. Barret J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 2:263-265.
2. Begic I., Cavka A., Mihalj M., Bacun T., Drenjancevic I. Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women. Med Glas 2012, 9(1):32-36.
3. Benoit Y.D., Lussier C., Ducharme P.A., Sivret S., Schnapp L.M., Basora N., et al. Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism. Biol Cell 2009, 101:695-708.
4. Bossy B., Bossy-Wetzel E., Reichardt L.F. Characterization of the integrin α8 subunit: a new integrin β1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos. EMBO J 1991, 10(9):2375-2385.
5. Bramachari S., Pahan K. Gender-specific expression of β 1 integrin of VLA-4 in myelin basic protein-primed T cells: implications for gender bias in multiple sclerosis. J Immunol 2010, 184:6103-6113.
6. Castle D., Sham P., Murray R. Differences in distribution of ages of onset in males and females with schizophrenia. Schizophr Res 1998, 33(3):179-183.
7. Chan C.S., Weeber E.J., Kurup S., Sweatt J.S., Davis R.L. Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci 2003, 23(18):7107-7116.
8. Chan C.S., Levenson J.M., Mukhopadyay P.S., Zong L., Bradley A., Sweatt J.D., et al. α3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem 2007, 14:606-615.
9. Chan M.K., Tsang T.M., Harris L.W., Guest P., Holmes E., Bahn S. Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients. Mol Psychiatry 2010, 16(12):1189-1202.
10. Chan C.S., Chen H., Bradley A., Dragatsis I., Rosemund C., Davis R.L. α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning. Genes Brain Behav 2010, 9:402-410.
11. Chu C.C., Abi-Dargam A., Ackerman B., Cetingok M., Klein H.E. Sex difference in schizophrenia. Int J Soc Psychiatry 1988, 35:237-244.
12. Chun D., Gall C.M., Bi X., Lynch G. Evidence that integrins contribute to multiple stages in the consolidation of long term potentiation in rat hippocampus. Neuroscience 2001, 105:815-829.
13. Corvin A.P. Neuronal cell adhesion genes. Key player in risk for schizophrenia, bipolar disorder, and other neurodevelopmental brain disorder?. Cell Adh Migr 2010, 4(4):511-514.
14. Costa E., Grayson D.R., Guidotti A. Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?. Mol Interv 2003, 3(4):220-229.
15. Devaux J., Gow A. Tight junctions potentiate the insulative properties of small CNS myelinated axons. J Cell Biol 2008, 183(5):909-921.
16. Dupont W.D., Plummer W.D. Power and sample size calculations for studies involving linear regression. Control Clin Trials 1998, 19:589-601.
17. Einheber S., Schnapp L.M., Salzer J.L., Cappiello Z.B., Milner T.A. Regional and ultrastructural distribution of the alpha 8 integrin subunit in developing and adult rat brain suggests a role in synaptic function. J Comp Neurol 1996, 370(1):105-134.
18. Ekwa-Ekoka C., Diaz G.A., Carlson C., Hasegawa T., Samudrala R., Lim K., et al. Genomic organization and sequence variation of the human integrin subunit α8 gene (ITGA8). Matrix Biol 2004, 23:487-496.
19. Gaur N., Gautam S., Gaur M., Sharma P., Dadheech G., Mishra S. The biochemical womb of schizophrenia: a review. Indian J Clin Biochem 2008, 23(4):307-327.
20. Giagtzoglou N., Ly C.V., Bellen H.J. Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol 2009, 1(aa003079):1-26.
21. Goh E.L.K., Young J.K., Kuwako K., Tessier-Lavigne M., He Z., Griffin J.W., et al. Beta I-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cone. Mol Brain 2008, 1-14.
22. Hildebrandt H., Muhlenhoff M., Oltmann-Norden I., Rockle I., Burkhardt H., Weinhold B., et al. Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain 2009, 132:2831-2838.
23. Honer W.G. Assessing the machinery of mind: synapse in neuropsychiatric disorder. J Psychiatry Neurosci 1999, 24(2):116-121.
24. Jones P., Murray R.M. The genetics of schizophrenia is the genetics of neurodevelopment. BJP 1991, 158:615-623.
25. Kirov G., O'Donovan M.C., Owen M.J. Finding schizophrenia genes. J Clin Invest 2005, 115:1440-1448.
26. Kramar E.A., Bernard J.A., Gall C.M., Lynch G. Alpha3 integrin receptors contribute to the consolidation of long-term potentiation. Neuroscience 2002, 110:29-39.
27. Kriebel M., Metzger J., Trinks S., Chugh D., Harvey R.J., Harvey K., et al. The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminal at the axon initial segment. J Biol Chem 2011, 286(27):24385-24393.
28. Lips E.S., Cornelisse L.N., Toonen R.F., Min J.L., Hultman C.M., the International Schizophrenia Consortium, et al. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry 2011, 1-11. [Epub ahead pints].
29. Maynard T.M., Sikich L., Lieberman J.A., LaMantia A.S. Neural development, cell-cell signaling, and the "Two hit" hypothesis of schizophrenia. Schizophr Bull 2001, 27(3):457-476.
30. Moresco E.M., Donaldson S., Williamson A., Koleske A.J. Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinase. J Neurosci 2005, 25(26):6105-6118.
31. Myers J.P., Gomez T.M. Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones. J Neurosci 2011, 31(38):13585-13595.
32. Nakamoto T., Kain K.H., Ginsberg M.H. Neurobiology: new connections between integrins and axon guidance. Curr Biol 2004, 14:121-123.
33. O'Dushlaine C., Kenny E., Heron E., Donohoe G., Gill M., The International Schizophrenia Consortium, et al. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry 2011, 16(3):286-292.
34. Pillai-Nair N., Panicker A.K., Rodriguiz R.M., Gilmore K.L., Demyanenko G.P., Huang J.Z., et al. Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. J Neurosci 2005, 25(18):4659-4671.
35. Ponthieux A., Herbeth B., Droesch S., Lambert D., Visvikis S. Age- and sex-related reference values for serum adhesion molecule concentrations in healthy individuals: intercellular adhesion molecule-1 and E-, P-, and L-selectin. Clin Chem 2003, 49(9):1544-1546.
36. Robertson G.S., Hori S.E., Powell K.J. Schizophrenia: an integrative approach to modeling a complex disorder. J Psychiatry Neurosci 2006, 31(3):157-167.
37. Stanco A., Szekeres C., Patel N., Rao S., Campbell K., Kreidberg J.A., et al. Netrin-1-αβ1 integrin interactions regulate the migration of interneurons through the cortical marginal zone. Proc Natl Acad Sci 2009, 106(18):7595-7600.
38. Takada Y., Ye X., Simon S. The integrins. Genome Biol 2007, 8(5):215.
39. Walsh T., McClellan J.M., McCarthy S.E., Addington A.M., Pierce S.B., Cooper G.M., et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 2008, 320:539-543.
40. Watanabe Y., Muratake T., Kaneko N., Nunokawa A., Someya T. No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Schizophr Res 2006, 84(1):29-35.
41. Yoshida M., Shiroiwa K., Mouri K., Ishiguro H., Supriyanto I., Ratta-Apha W., et al. Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia. Schizophr Res 2012, 140(1-3):185-192.