Serum level of soluble fibrinogen-like protein 2 in renal allograft recipients with acute rejection: A preliminary study

Transplantation Proceedings

Volumn 44, Issue 10, 2012, Pages 2982-2985

  Zhao, Z ^a   Yang, C ^a,b   Tang, Q ^a   Zhao, T ^b   Jia, Y ^a   Ma, Z ^a   Rong, R ^a   Xu, M ^b   Zhu, T ^a,b  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Key Laboratory of Organ Transplantation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; FIBRINOGEN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; SOLUBLE FIBRINOGEN LIKE PROTEIN 2; TACROLIMUS; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BIOPSY; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; T LYMPHOCYTE;

ACUTE DISEASE; ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; CHI-SQUARE DISTRIBUTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOGEN; GRAFT REJECTION; HUMANS; IMMUNITY, CELLULAR; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY; TREATMENT OUTCOME; UP-REGULATION;

EID: 84870182399     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2012.05.082     Document Type: Article

References (21)

1. M. Pascual, T. Theruvath, T. Kawai Strategies to improve long-term outcomes after renal transplantation N Engl J Med 346 2002 580
2. S. Yuwaraj, J. Ding, M. Liu Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant Genomics 71 2001 330
3. C.L. Zhu, W.M. Yan, F. Zhu Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B World J Gastroenterol 11 2005 6936
4. Q. Ning, Y. Sun, M. Han Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection J Immunol 174 2005 7403
5. I. Shalev, H. Liu, C. Koscik Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis J Immunol 180 2008 249
6. M. Mendicino, M. Liu, A. Ghanekar Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts Circulation 112 2005 248
7. A. Ghanekar, M. Mendicino, H. Liu Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection J Immunol 172 2004 5693
8. S. Marazzi, S. Blum, R. Hartmann Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes J Immunol 161 1998 138
9. T.L. Denning, S.W. Granger, D. Mucida Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses J Immunol 178 2007 4230
10. C.W. Chan, L.S. Kay, R.G. Khadaroo Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells J Immunol 170 2003 4036
11. K. Solez, R.B. Colvin, L.C. Racusen Banff 07 classification of renal allograft pathology: updates and future directions Am J Transplant 8 2008 753
12. K.J. Wood Regulatory T cells in transplantation Transplant Proc 43 2011 2135
13. S. Wei, I. Kryczek, W. Zou Regulatory T-cell compartmentalization and trafficking Blood 108 2006 426
14. E.C. Aquino-Dias, G. Joelsons, D.M. da Silva Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function Kidney Int 73 2008 877
15. C. Taflin, D. Nochy, G. Hill Regulatory T cells in kidney allograft infiltrates correlate with initial inflammation and graft function Transplantation 89 2010 194
16. C.D. Dummer, V.N. Carpio, L.F. Goncalves FOXP3+ regulatory T cells: from suppression of rejection to induction of renal allograft tolerance Transpl Immunol 26 2012 1
17. I. Shalev, K.M. Wong, K. Foerster The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis Hepatology 49 2009 387
18. K. Foerster, A. Helmy, Y. Zhu The novel immunoregulatory molecule FGL2: a potential biomarker for severity of chronic hepatitis C virus infection J Hepatol 53 2010 608
19. S.M. Séverine Bézie, T. Laurent, X.L. Li Immunosuppressive role of fibrinogen-like protein 2 (FGL2) in CD8+regulatory T cells-mediated long-term graft survival J Transl Med 9 suppl 2 2011 O5
20. N. Zhang, B. Schroppel, G. Lal Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response Immunity 30 2009 458
21. L. Xie, M. Ichimaru, M. Morita Identification of a novel biomarker gene set with sensitivity and specificity to distinguish between allograft rejection and tolerance Liver Transpl 18 2012 444