Progressive transformation of germinal centers in children and adolescents: An intriguing cause of lymphadenopathy

Pediatric Blood and Cancer

Volumn 60, Issue 1, 2013, Pages 26-30

  Shaikh, Furqan ^a   Ngan, Bo Yee ^a   Alexander, Sarah ^a   Grant, Ronald ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Anatomic pathology; Immune cytopenias; Lymphoma; Reactive follicular hyperplasia

Indexed keywords

ADOLESCENT; ADULT; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; CHILD; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HODGKIN DISEASE; HUMAN; INFANT; LUPUS VULGARIS; LYMPH NODE BIOPSY; LYMPHADENOPATHY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGRESSIVE TRANSFORMATION OF GERMINAL CENTER; RECURRENT DISEASE; RETROSPECTIVE STUDY; SCHOOL CHILD;

ADOLESCENT; BIOPSY; CHILD; CHILD, PRESCHOOL; FEMALE; GERMINAL CENTER; HODGKIN DISEASE; HUMANS; INFANT; LYMPHATIC DISEASES; MALE; RETROSPECTIVE STUDIES;

EID: 84870178691     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24234     Document Type: Article

References (25)

1. Hicks J, Flaitz C. Progressive transformation of germinal centers: Review of histopathologic and clinical features. Int J Pediatr Otorhinolaryngol 2002; 65: 195-202.
2. Hansmann ML, Fellbaum C, Hui PK, et al. Progressive transformation of germinal centers with and without association to Hodgkin's disease. Am J Clin Pathol 1990; 93: 219-226.
3. Lennert K, Muller-Hermelink HK. Lymphocten and ihre funktionsformen morphologie, organisation and immunologische bedeutung. Verh Anat GEs 1975; 69: 19-62.
4. Poppema S, Kaiserling E, Lennert K. Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings. Virchows Arch B Cell Pathol 1979; 31: 211-225.
5. Chang C-C, Osipov V, Wheaton S, et al. Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasia. Am J Clin Pathol 2003; 120: 322-326.
6. Burns BF, Colby TV, Dorfman RF. Differential diagnostic features of nodular L&H Hodgkin's disease, including progressive transformation of germinal centers. Am J Surg Pathol 1984; 8: 253-261.
7. Brauninger A, Yang W, Wacker HH, et al. B-cell development in progressively transformed germinal centers: Similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease. Blood 2001; 97: 714-719.
8. Nguyen PL, Ferry JA, Harris NL. Progressive transformation of germinal centers and nodular lymphocyte predominance Hodgkin's disease: A comparative immunohistochemical study. Am J Surg Pathol 1999; 23: 27-33.
9. Ferry JA, Zukerberg LR, Harris NL. Florid progressive transformation of germinal centers. A syndrome affecting young men, without early progression to nodular lymphocyte predominance Hodgkin's disease. Am J Surg Pathol 1992; 16: 252-258.
10. Licup AT, Campisi P, Ngan B-Y, et al. Progressive transformation of germinal centers: An uncommon cause of pediatric cervical lymphadenopathy. Arch Otolaryngol Head Neck Surg 2006; 132: 797-801.
11. Verma A, Stock W, Norohna S, et al. Progressive transformation of germinal centers. Report of 2 cases and review of the literature. Acta Haematol 2002; 108: 33-38.
12. Kojima M, Nakamura S, Motoori T, et al. Progressive transformation of germinal centers: A clinicopathological study of 42 Japanese patients. Int J Surg Pathol 2003; 11: 101-107.
13. Osborne BM, Butler JJ, Gresik MV. Progressive transformation of germinal centers: Comparison of 23 pediatric patients to the adult population. Mod Pathol 1992; 5: 135-140.
14. Osborne BM, Butler JJ. Clinical implications of progressive transformation of germinal centers. Am J Surg Pathol 1984; 8: 725-733.
15. Poppema S, Kaiserling E, Lennert K. Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres-A cytohistological study. Histopathology 1979; 3: 295-308.
16. Soglio DB, Truong F, Fetni R, et al. A B-cell lymphoma-associated chromosomal translocation in a progressive transformation of germinal center. Hum Pathol 2008; 39: 292-297.
17. Nicholas DS, Harris S, Wright DH. Lymphocyte predominance Hodgkin's disease-An immunohistochemical study. Histopathology 1990; 16: 157-165.
18. Crossley B, Heryet A, Gatter KC. Does nodular lymphocyte predominant Hodgkin's disease arise from progressively transformed germinal centres? A case report with an unusually prolonged history. Histopathology 1987; 11: 621-630.
19. Lee AI, LaCasce AS. Nodular lymphocyte predominant Hodgkin lymphoma. Oncologist 2009; 14: 739-751.
20. Epelbaum R, Ben-Arie Y, Bar-Shalom R, et al. Benign proliferative lesions mimicking recurrence of Hodgkin's disease. Med Pediatr Oncol 1997; 28: 187-190.
21. Makis W, Ciarallo A, Novales-Diaz J-A, et al. Progressive transformation of germinal centers in a pediatric patient: Initial evaluation and follow-up with serial F-18 FDG PET/CT imaging. Clin Nucl Med 2011; 36: e139-e141.
22. Levine JM, Weiner M, Kelly KM. Routine use of PET scans after completion of therapy in pediatric Hodgkin disease results in a high false positive rate. J Pediatr Hematol Oncol 2006; 28: 711-714.
23. Grigg A, Ganju V. PET positive progressive transformation of germinal centers masquerading as relapsed Hodgkin lymphoma post-autograft. Leuk Lymphoma 2006; 47: 764-765.
24. Oliveira JB, Bleesing JJ, Dianzani U, et al. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): Report from the 2009 NIH International Workshop. Blood 2010; 116: e35-e40.
25. Lim MS, Straus SE, Dale JK, et al. Pathological findings in human autoimmune lymphoproliferative syndrome. Am J Pathol 1998; 153: 1541-1550.