First report of the use of a saxitoxin-protein conjugate to develop a DNA aptamer to a small molecule toxin

Toxicon

Volumn 61, Issue 1, 2013, Pages 30-37

  Handy, Sara M ^a   Yakes, Betsy Jean ^a   DeGrasse, Jeffrey A ^a   Campbell, Katrina ^b   Elliott, Christopher T ^b   Kanyuck, Kelsey M ^c   DeGrasse, Stacey L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Aptamer; Marine toxin; Paralytic shellfish toxins; Saxitoxin; Surface plasmon resonance

Indexed keywords

APTAMER; KEYHOLE LIMPET HEMOCYANIN; SAXITOXIN; SINGLE STRANDED DNA; SINGLE STRANDED DNA APTAMER; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SEQUENCE; HAPTEN CARRIER COMPLEX; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SENSOR; SURFACE PLASMON RESONANCE; TOXIN ANALYSIS;

ANIMALS; APTAMERS, NUCLEOTIDE; BASE SEQUENCE; CALIBRATION; DNA PRIMERS; DNA, SINGLE-STRANDED; DRUG CARRIERS; HAPTENS; HEMOCYANIN; IMMUNOTOXINS; MAGNETICS; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; SAXITOXIN; SURFACE PLASMON RESONANCE;

ANIMALIA; DINOPHYCEAE;

EID: 84870175600     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.10.015     Document Type: Article

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