CD4 T-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Wang, Li Chiu ^a   Kao, Chia Min ^a   Ling, Pin ^a   Su, Ih Jen ^b   Chang, Tung Miao ^c   Chen, Shun Hua ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c TAINAN UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; NEUTRALIZING ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENTEROVIRUS 71; ENTEROVIRUS 71 INFECTION; ENTEROVIRUS INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; T CELL DEPLETION; VIRUS LOAD; VIRUS STRAIN; WILD TYPE; ANIMAL; ANTIBODY PRODUCTION; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; ENTEROVIRUS; IMMUNOLOGY; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIBODY FORMATION; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MICE; MICE, INBRED C57BL; VIRAL LOAD;

EID: 84870169234     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/580696     Document Type: Article

References (32)

1. Chang L. Y., Huang L. M., Gau S. S. F., Wu Y. Y., Hsia S. H., Fan T. Y., Lin K. L., Huang Y. C., Lu C. Y., Lin T. Y., Neurodevelopment and cognition in children after enterovirus 71 infection. The New England Journal of Medicine 2007 356 12 1226 1234 2-s2.0-33947531683 10.1056/NEJMoa065954 (Pubitemid 46465598)
2. Ho M., Chen E. R., Hsu K. H., Twu S. J., Chen K. T., Tsai S. F., Wang J. R., Shih S. R., An epidemic of enterovirus 71 infection in Taiwan. The New England Journal of Medicine 1999 341 13 929 935 2-s2.0-0033598371 10.1056/NEJM199909233411301 (Pubitemid 29441546)
3. Huang C. C., Liu C. C., Chang Y. C., Chen C. Y., Wang S. T., Yeh T. F., Neurologic complications in children with enterovirus 71 infection. The New England Journal of Medicine 1999 341 13 936 942 2-s2.0-0033598405 10.1056/NEJM199909233411302 (Pubitemid 29441547)
4. Qiu J., Enterovirus 71 infection: a new threat to global public health? The Lancet Neurology 2008 7 10 868 869 2-s2.0-51449094803 10.1016/S1474-4422(08) 70207-2
5. Chang L. Y., Hsiung C. A., Lu C. Y., Lin T. Y., Huang F. Y., Lai Y. H., Chiang Y. P., Chiang B. L., Lee C. Y., Huang L. M., Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatric Research 2006 60 4 466 471 2-s2.0-33748897695 10.1203/01.pdr. 0000238247.86041.19 (Pubitemid 44427602)
6. Wang S. M., Lei H. Y., Huang K. J., Wu J. M., Wang J. R., Yu C. K., Su I. J., Liu C. C., Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. Journal of Infectious Diseases 2003 188 4 564 570 2-s2.0-0041941423 10.1086/376998 (Pubitemid 37011809)
7. Chang L. Y., Hsia S. H., Wu C. T., Huang Y. C., Lin K. L., Fang T. Y., Lin T. Y., Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002. Pediatric Infectious Disease Journal 2004 23 4 327 332 2-s2.0-1942451895 10.1097/00006454-200404000-00010 (Pubitemid 38508885)
8. Hsia S. H., Wu C. T., Chang J. J., Lin T. Y., Chung H. T., Lin K. L., Hwang M. S., Chou M. L., Chang L. Y., Predictors of unfavorable outcomes in enterovirus 71-related cardiopulmonary failure in children. Pediatric Infectious Disease Journal 2005 24 4 331 334 2-s2.0-17144369122 10.1097/01.inf.0000157219. 19674.98 (Pubitemid 40525341)
9. Lum L. C. S., Wong K. T., Lam S. K., Chua K. B., Goh A. Y. T., Lim W. L., Ong B. B., Paul G., AbuBakar S., Lambert M., Fatal enterovirus 71 encephalomyelitis. Journal of Pediatrics 1998 133 6 795 798 2-s2.0-0031674713 (Pubitemid 28563953)
10. Wang S. M., Liu C. C., Tseng H. W., Wang J. R., Huang C. C., Chen Y. J., Yang Y. J., Lin S. J., Yeh T. F., Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications. Clinical Infectious Diseases 1999 29 1 184 190 2-s2.0-0032766008
11. Yan J. J., Wang J. R., Liu C. C., Yang H. B., Su I. J., An outbreak of enterovirus 71 infection in Taiwan 1998: a comprehensive pathological, virological, and molecular study on a case of fulminant encephalitis. Journal of Clinical Virology 2000 17 1 13 22 2-s2.0-0034063305 10.1016/S1386-6532(00) 00067-6 (Pubitemid 30256287)
12. McMinn P., Stratov I., Nagarajan L., Davis S., Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clinical Infectious Diseases 2001 32 2 236 242 2-s2.0-0035245224 10.1086/318454 (Pubitemid 32524793)
13. Nolan M. A., Craig M. E., Lahra M. M., Rawlinson W. D., Prager P. C., Williams G. D., Bye A. M. E., Andrews P. I., Survival after pulmonary edema due to enterovirus 71 encephalitis. Neurology 2003 60 10 1651 1656 2-s2.0-0037799494 (Pubitemid 36618093)
14. Wang S. M., Lei H. Y., Su L. Y., Wu J. M., Yu C. K., Wang J. R., Liu C. C., Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clinical Microbiology and Infection 2007 13 7 677 682 2-s2.0-34250316594 10.1111/j.1469-0691.2007.01729.x (Pubitemid 46909344)
15. Lin T. Y., Hsia S. H., Huang Y. C., Wu C. T., Chang L. Y., Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system. Clinical Infectious Diseases 2003 36 3 269 274 2-s2.0-0037310094 10.1086/345905 (Pubitemid 36169660)
16. Lin Y. W., Chang K. C., Kao C. M., Chang S. P., Tung Y. Y., Chen S. H., Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads. Journal of Virology 2009 83 13 6477 6483 2-s2.0-67449100985 10.1128/JVI.00434-09
17. Li Z. H., Li C. M., Ling P., Shen F. H., Chen S. H., Liu C. C., Yu C. K., Chen S. H., Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication. Journal of Infectious Diseases 2008 197 6 854 857 2-s2.0-40949089777 10.1086/527326 (Pubitemid 351417008)
18. Wang Y. F., Chou C. T., Lei H. Y., Liu C. C., Wang S. M., Yan J. J., Su I. J., Wang J. R., Yeh T. M., Chen S. H., Yu C. K., A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. Journal of Virology 2004 78 15 7916 7924 2-s2.0-3242704988 10.1128/JVI.78.15.7916-7924.2004 (Pubitemid 38944277)
19. Yu C. K., Chen C. C., Chen C. L., Wang J. R., Liu C. C., Yan J. J., Su I. J., Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice. Journal of Biomedical Science 2000 7 6 523 528 2-s2.0-0033773155
20. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 1991 353 6340 180 184 2-s2.0-0025817991 10.1038/353180a0 (Pubitemid 21912486)
21. Staats H. F., Oakes J. E., Lausch R. N., Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. Journal of Virology 1991 65 11 6008 6014 2-s2.0-0026044405
22. Alugupalli K. R., Leong J. M., Woodland R. T., Muramatsu M., Honjo T., Gerstein R. M., B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 2004 21 3 379 390 2-s2.0-4444335352 10.1016/j.immuni.2004.06.019 (Pubitemid 39208339)
23. Ochsenbein A. F., Pinschewer D. D., Odermatt B., Carroll M. C., Hengartner H., Zinkernagel R. M., Protective T cell-independent antiviral antibody responses are dependent on complement. Journal of Experimental Medicine 1999 190 8 1165 1174 2-s2.0-0032753625 10.1084/jem.190.8.1165 (Pubitemid 29496509)
24. Bachmann M. F., Zinkernagel R. M., Neutralizing antiviral B cell responses. Annual Review of Immunology 1997 15 235 270 2-s2.0-0030929806 10.1146/annurev.immunol.15.1.235 (Pubitemid 27169281)
25. Berland R., Wortis H. H., Origins and functions of B-1 cells with notes on the role of CD5. Annual Review of Immunology 2002 20 253 300 2-s2.0-0036217975 10.1146/annurev.immunol.20.100301.064833 (Pubitemid 34293426)
26. Lee B. O., Rangel-Moreno J., Moyron-Quiroz J. E., Hartson L., Makris M., Sprague F., Lund F. E., Randall T. D., CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. Journal of Immunology 2005 175 9 5827 5838 2-s2.0-27144530970 (Pubitemid 41508067)
27. Wagner R., The Rhabdoviruses 1987 New York, NY, USA Plenum Press
28. Racaniello V. R., Knipe D. M., Howley P. M., Griffin D. E., Picornaviridae: the viruses and their replication. Fields Virology 2007 Philadelphia, Pa, USA Lippincott Williams & Wilkins 796 838
29. McKinney R. E. Jr., Katz S. L., Wilfert C. M., Chronic enteroviral meningoencephalitis in agammaglobulinemic patients. Reviews of Infectious Diseases 1987 9 2 334 356 2-s2.0-0023299209
30. Wilfert C. M., Buckley R. H., Mohanakumar T., Persistent and fatal central nervous system echovirus infections in patients with agammaglobulinemia. The New England Journal of Medicine 1977 296 26 1485 1489 2-s2.0-0017744543 (Pubitemid 8140558)
31. Abzug M. J., Keyserling H. L., Lee M. L., Levin M. J., Rotbart H. A., Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin. Clinical Infectious Diseases 1995 20 5 1201 1206 2-s2.0-0028997937
32. Wang S. M., Lei H. Y., Huang M. C., Su L. Y., Lin H. C., Yu C. K., Wang J. L., Liu C. C., Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. Journal of Clinical Virology 2006 37 1 47 52 2-s2.0-33747793073 10.1016/j.jcv.2006.05.009 (Pubitemid 44279536)