An in vitro assessment of the interaction of cadmium selenide quantum dots with DNA, iron, and blood platelets

IUBMB Life

Volumn 64, Issue 12, 2012, Pages 995-1002

  Dunpall, Rekha ^a   Nejo, Adeola Ayodeji ^a   Pullabhotla, Viswanadha Srirama Rajasekhar ^a   Opoku, Andy R ^a   Revaprasadu, Neerish ^a   Shonhai, Addmore ^a  

^a UNIVERSITY OF ZULULAND   (South Africa)

Author keywords

cadmium selenide; DNA damage; platelets; quantum dots; red blood cell; toxicity; water soluble

Indexed keywords

BIOMATERIAL; CADMIUM SELENIDE; DNA; EDETIC ACID; FERRIC CHLORIDE; FERROUS ION; FERROZINE; HEMOGLOBIN; IRON; NANOCRYSTAL; PLASMID DNA; POTASSIUM FERRICYANIDE; QUANTUM DOT; THROMBIN; TRICHLOROACETIC ACID;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BLOOD CLOTTING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DAMAGE; ERYTHROCYTE; IN VITRO STUDY; IRON CHELATION; NONHUMAN; PARTICLE SIZE; PHOTOLUMINESCENCE; RAT; THROMBOCYTE; THROMBOCYTE AGGREGATION;

BLOOD PLATELETS; CADMIUM COMPOUNDS; CYSTEINE; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IRON; IRON CHELATING AGENTS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR PROBES; NUCLEIC ACID DENATURATION; OXIDATION-REDUCTION; PARTICLE SIZE; PLATELET AGGREGATION; QUANTUM DOTS; SELENIUM COMPOUNDS; WATER;

EID: 84870157309     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1100     Document Type: Article

References (22)

1. De, M., Partha, S., Ghosh, S., and, Rotello, V. M., (2008) Applications of nanoparticles in biology. Adv. Mater. 20, 4225-4241.
2. Lewinski, N., Colvin, V., and, Drezek, R., (2008) Cytotoxicity of nanoparticles. Small 4, 26-49.
3. Oberdorster, G., Oberdorster, E., and, Oberdorster, J., (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113, 823.
4. Chan, W. H., and, Shiao, N. H., (2008) Cytotoxic effect of CdSe quantum dots on mouse embryonic development. Acta Pharmacol. Sin. 29, 259-66.
5. Nazem, A., and, Mansoori, G. A., (2011) Nanotechnology for Alzheimer's disease detection and treatment. Insciences J. 1, 169-193.
6. Ghaderi, S., Ramesh, B., and, Seifalian, A. M., (2011) Fluorescence nanoparticles "quantum dots" as drug delivery system and their toxicity: a review. J. Drug Target. 19, 475-486.
7. Derfus, A. M., Chan, W.C.W., and, Bhatia, S. N., (2003) Probing the cytotoxicity of semiconductor quantum dots. Nano. Lett. 4, 11-18.
8. Liu, W., Zhang, S., Wang, L., Qu, C., Zhang, C., Hong, L., Yuan, L., Huang, Z., Wang, Z., Liu, S., and, Jiang, G., (2011) CdSe quantum dot (QD)-induced morphological and functional impairments to liver in mice. PLoS ONE 6, e24406.
9. Pace, H. E., Lesher, E. K., and, Ranville, J. F., (2010) Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna. Environ. Toxicol. Chem. 29, 1338-1344.
10. Brus, L. E., (1986) Semiconductor quantum dots. J. Chem. Phys. 90, 2555-2560.
11. Oluwafemi, S. O., Revaprasadu, N., and, Ramirez, A., (2008) A novel one-pot route for the synthesis of water soluble CdSe nanoparticles. J. Cryst. Growth 310, 3230.
12. Posgai, R., Ahamed, M., Hussain, S. M., Rowe, J. J., and, Nielsen, M. G., (2009). Inhalation method for delivery of nanoparticles to the Drosophila respiratory system for toxicity testing. Sci. Total Environ. 408, 439-443.
13. Nagy, A., Steinbrück, A., Gao, J., Doggett, N., Hollingsworth, J. A., and, Iyer, R., (2012) Comprehensive Analysis of the effects of CdSe quantum dot size, surface charge, and functionalization on primary human lung cells. ACS Nano. 6, 4748-4762
14. Habib, A., and, Tabata, M., (2004) Oxidative DNA damage induced by HEPES (2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid) buffer in the presence of Au(III). J. Inorg. Biochem. 98, 1696-1702. (Pubitemid 39452678)
15. Trouiller, B., Reliene, R., Westbrook, A., Solaimani, P., and, Schiestl, R. H., (2009) Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res. 69, 8784-8789.
16. Mekhfi, H., ElHaouari, H., Bnouham, M., Aziz, M., Ziyyat, A., and, Legssyer, A., (2006) Effects of extracts and tannins from Arbutus unedo leaves on rat platelet aggregation. Phytother. Res. 20, 135-139. (Pubitemid 43266839)
17. Oyaizu, M., (1986) Studies on products of browning reactions; antioxidant activities of products of browning reactions prepared from glucose amine. Jap. J. Nutrit. 44, 307-315.
18. Derker, E. A., and, Welch, B., (1990) Role of ferritin as a lipid oxidation catalyst in muscle food. J. Agric. Food Chem. 38, 674-677.
19. Kuhlbusch, T. A. J., Asbach, C., Fissan, H., Gohler, D., and, Stinz, M., (2011) Nanoparticle exposure at nanotechnology workplaces: a review. Part Fibre Toxicol. 8, 22
20. Radomski, A., Jurasz, P., Alonso-Escolano, D., Drews, M., Morandi, M., Malinski, T., and, Radomski, M. W., (2005) Nanoparticle-induced platelet aggregation and vascular thrombosis. Br. J. Pharmacol. 146, 882-893. (Pubitemid 41622255)
21. Oslakovic, C., Cedervall, T., Linse, S., and, Dahlbäck, B., (2011) Polystyrene nanoparticles affecting blood coagulation. Nanomedicine 8, 981-986.
22. Winnik, F. M., and, Maysinger, D., Quantum dot cytotoxicity and ways to reduce it. Acc. Chem. Res., in press; DOI: 10.1021/ar3000585.