Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 12, 2012, Pages 2855-2861

  Lipinski, Michael J ^a,c   Campbell, Kirsti A ^a   Duong, Son Q ^a   Welch, Thomas J ^a   Garmey, James C ^a   Doran, Amanda C ^a,c   Skaflen, Marcus D ^a   Oldham, Stephanie N ^a,b   Kelly, Kimberly A ^a,d   McNamara, Coleen A ^a,b,c  

^a Cardiovascular Research Center   (United States)

^b Department of Medicine   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d University of Virginia   (United States)

Author keywords

Loss of Id3 Increases VCAM 1 Expression, Macrophage Accumulation, and Atherogenesis in Ldlr Mice

Indexed keywords

CHEMOKINE; E12 PROTEIN; INHIBITOR OF DIFFERENTIATION 3; LIPID; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENESIS; B LYMPHOCYTE; CELL DENSITY; CHEMOTAXIS; CHROMATIN IMMUNOPRECIPITATION; GAIN OF FUNCTION MUTATION; GENE INACTIVATION; GENOTYPE; IMMUNOHISTOCHEMISTRY; LIPID BLOOD LEVEL; LOSS OF FUNCTION MUTATION; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; ATHEROSCLEROSIS; B-LYMPHOCYTES; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CCL20; DISEASE MODELS, ANIMAL; INHIBITOR OF DIFFERENTIATION PROTEINS; MACROPHAGES; MICE; MICE, KNOCKOUT; PREVALENCE; RECEPTORS, LDL; RISK FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84870063104     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300352     Document Type: Article

References (23)

1. Roger VL, Go AS, LloydJones DM, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation. 2011;123:e18-e209.
2. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317-325.
3. Doran AC, Lipinski MJ, Oldham SN, et al. Bcell aortic homing and atheroprotection depend on Id3. Circ Res. 2012;110:e1-12.
4. Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA. Id3 is a novel atheroprotective factor containing a functionally significant singlenucleotide polymorphism associated with intimamedia thickness in humans. Circ Res. 2010;106:1303-1311.
5. Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basichelixloophelix transcription factors. J Biol Chem. 1997;272:19785-19793. (Pubitemid 27340071)
6. Engel I, Murre C. The function of E and Id proteins in lymphocyte development. Nat Rev Immunol. 2001;1:193-199.
7. Chen B, Han BH, Sun XH, Lim RW. Inhibition of musclespecific gene expression by Id3: requirement of the Cterminal region of the protein for stable expression and function. Nucleic Acids Res. 1997;25:423-430. (Pubitemid 27303338)
8. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470-475.
9. Roeschlau P, Bernt E, Gruber W. Enzymatic determination of total cholesterol in serum. Z Klin Chem Klin Biochem. 1974;12:226.
10. Daugherty A, Whitman SC. Quantification of atherosclerosis in mice. Methods Mol Biol. 2003;209:293-309.
11. Movat HZ. Demonstration of all connective tissue elements in a single section; pentachrome stains. AMA Arch Pathol. 1955;60:289-295.
12. Kitamura D, Roes J, Kühn R, Rajewsky K. A B celldeficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991;350:423-426. (Pubitemid 21912244)
13. Galkina E, Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27:2292-2301. (Pubitemid 350203942)
14. Lusis AJ, Mar R, Pajukanta P. Genetics of atherosclerosis. Annu Rev Genomics Hum Genet. 2004;5:189-218. (Pubitemid 39362746)
15. Klingenberg R, Hansson GK. Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies. Eur Heart J. 2009;30:2838-2844.
16. Norton JD, Deed RW, Craggs G, Sablitzky F. Id helixloophelix proteins in cell growth and differentiation. Trends Cell Biol. 1998;8:58-65. (Pubitemid 28056812)
17. Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, Murre C. The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat Immunol. 2011;12:992-1001.
18. Calvayrac O, RodríguezCalvo R, Alonso J, Orbe J, MartínVentura JL, Guadall A, Gentile M, JuanBabot O, Egido J, Beloqui O, Paramo JA, Rodríguez C, MartínezGonzález J. CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: role of NFκB. Arterioscler Thromb Vasc Biol. 2011;31:2733-2741.
19. Wan W, Lim JK, Lionakis MS, Rivollier A, McDermott DH, Kelsall BL, Farber JM, Murphy PM. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoEdeficient mice. Circ Res. 2011;109:374-381.
20. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR. VCAM1 on activated endothelium interacts with the leukocyte integrin VLA4 at a site distinct from the VLA4/fibronectin binding site. Cell. 1990;60:577-584.
21. Huo Y, HafeziMoghadam A, Ley K. Role of vascular cell adhesion molecule1 and fibronectin connecting segment1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ Res. 2000;87:153-159. (Pubitemid 30616912)
22. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, GutierrezRamos JC, Connelly PW, Milstone DS. A major role for VCAM1, but not ICAM1, in early atherosclerosis. J Clin Invest. 2001;107:1255-1262. (Pubitemid 32494542)
23. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J, Cybulsky MI, Smith JD. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule1 gene dosage. Arterioscler Thromb Vasc Biol. 2001;21:1662-1667. (Pubitemid 34215588)