Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp

Phytomedicine

Volumn 19, Issue 14, 2012, Pages 1256-1262

  Dai, Haixue ^a   Li, Xiaorong ^a   Li, Xiaoli ^a   Bai, Lu ^a   Li, Yuhang ^a   Xue, Ming ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Absorption; Cryptotanshinone; Everted rat gut sacs; HPLC; Interaction; P glycoprotein inhibitor; Salvia miltiorrhiza

Indexed keywords

CRYPTOTANSHINONE; DANXINGFANG; DITERPENOID; GLYCOPROTEIN P INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; TANSHINONE; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; GASTROINTESTINAL SECRETION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; MALE; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; RAT; SALVIA MILTIORRHIZA;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; INTESTINAL ABSORPTION; INTESTINES; P-GLYCOPROTEIN; PHENANTHRENES; PLANT ROOTS; RATS; SALVIA; SALVIA MILTIORRHIZA;

RATTUS; SALVIA MILTIORRHIZA; SALVIA PRZEWALSKII;

EID: 84870056649     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.08.007     Document Type: Article

References (33)

1. R. An, X.H. Wang, S.L. Zhou, L.S. You, Z.H. Wang, X.K. Hong, and Y.Q. Wang Determination of fat-soluble component in Radix Salvia miltiorrhizae from different sources Chinese Traditional Patent Medicine 26 2004 294 297
2. R. An, X.H. Wang, Y. Tang, and J.Z. Zhang Comparison of water-soluble component in danshen from different sources Chinese Traditional Patent Medicine 27 2005 812 815
3. L. Barthe, M. Bessouet, J.F. Woodley, and G.T. Houin The improved everted gut sac: a simple method to study intestinal P-glycoprotein International Journal of Pharmaceutics 173 1998 255 258
4. R. Bouer, L. Barthe, C. Philibert, C. Tournaire, J. Woodley, and G. Houin The role of P-glycorprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac Fundamental Clinical Pharmacology 13 1999 494 500
5. B. Carreno-Gomez, and R. Duncan Everted rat intestinal sacs: a new model for the quantitation of P-glycoprotein mediated-efflux of anticancer agents Anticancer Research 20 2000 3157 3161
6. M.L. Chen, Q.Y. Shou, Y.M. Pan, J.B. Zhang, R. Sang, M.W. Guan, and B.Y. Wu Inhibitive and protective effects of guanxinning tablets on platelet aggregation and vascular endothelium in qi stagnation and blood stasis rats Chinese Journal of Clinical Pharmacology and Therapeutics 5 2005 586 589
7. Y. Chen, X.R. Li, J. Gao, Y. Tang, M.M. Wang, and M. Xue Protective effect of dangxiongfang on brain in hypoxia mice Traditional Chinese Drug Research & Clinical Pharmacology 19 2008 366 368
8. Y. Cui, M. Xue, Y.J. Luo, B. Zhang, and Z.T. Zhou Pharmacokinetics and excretion of cryptotanshinone after intravenous injection in pigs Asian Journal of Drug Metabolism and Pharmacokinetics 5 2005 231 235
9. n Journal of Pharmaceutical and Biomedical Analysis 48 2008 885 896
10. C.A. Doige, and G.F. Ames ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistance Annual Review of Microbiology 47 1993 291 319
11. Y. Emi, D. Tsunashima, K. Ogawara, K. Higaki, and T. Kimura Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine Journal of Pharmaceutical Sciences 87 1998 295 299
12. Y.G. Gao, Y.M. Song, Y.Y. Yang, J.X. Tang, and W.F. Liu Pharmacology of tanshinone Acta Pharmaceutica Sinica 14 1979 75 82
13. D.Y. Kong Chemical constituents of Salvia miltiorrhiza Chinese Journal of Pharmaceutical 20 1989 279 285
14. X.L. Li, X.R. Li, L.J. Wang, Y.H. Li, Y.X. Xu, and M. Xue Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang Journal of Pharmaceutical and Biomedical Analysis 44 2007 1106 1112
15. X.L. Li, X.R. Li, L.J. Wang, Y.H. Li, and M. Xue Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone II A in danxiongfang prescription by HPLC Chinese Traditional Patent Medicine 30 2008 77 80
16. X.R. Li, X.L. Li, L.J. Wang, Y.H. Li, Y.X. Xu, and M. Xue Pharmacokinetic interaction of ferulic acid and danshensu, the hydrophilic principal components of danshen and chuanxiong Chinese Pharmacological Bulletin 23 2007 968 972
17. 4 in mice China Journal of Chinese Materia Medica 32 2007 2177 2181
18. X.R. Li, L.J. Wang, Y.H. Li, Y.X. Xu, Y. Chen, J.X. Ruan, and M. Xue Effect of danxiongfang on reducing serum lipids level in rat model with hyperlipidemia induced by high lipid diet Chinese Journal of Experimental Traditional medical Formulae 14 2008 42 45
19. X.R. Li, Y.J. Luo, L.J. Wang, Y.H. Li, Y.B. Shi, Y. Cui, and M. Xue Acute and subcute toxicity of ethanol extracts from Salvia przewalskii Maxim in rodents Journal of Ethnopharmacology 126 2010 197 206
20. Y. Liu, X.R. Li, Y.H. Li, L.J. Wang, and M. Xue Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats Journal of Pharmaceutical and Biomedical Analysis 53 2010 698 704
21. M. Song, T.J. Hang, Z.X. Zhang, and H.Y. Chen Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanhinone IIA in rat European Journal of Pharmaceutical Sciences 32 2007 247 253
22. B.H. Stewart, O.H. Chan, R.H. Lu, E.L. Reyner, H.L. Schmid, H.W. Hamilton, B.A. Steinbaugh, and M.D. Taylor Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans Pharmaceutical research 12 1995 693 699
23. L. Su, and Q.D. Liu Recent researches on pharmacological actions of tanshinone II A Chinese Journal of Pharmaceutical Technology Economics and Management 3 2009 39 45
24. J.W. Xu, and C.M. Fu Progress of Salvia militiorrhiza in pharmaceutical action Medical Recapitulate 12 2006 1467 1468
25. R.S. Xu Biological and Application of Salvia miltiorrhiza Bunge 1990 Scientific Publishing Company Beijing pp. 81-184
26. M. Xue, Y. Cui, H.Q. Wang, Z.Y. Hu, and B. Zhang Reversed-phase liquid chromatographic determination of cryptotanshinone and its active metabolite in pig plasma and urine Journal of Pharmaceutical and Biomedical Analysis 21 1999 207 211
27. M. Xue, Y.B. Shi, Y. Cui, H.Q. Wang, B. Zhang, and Y.J. Luo Study on the chemical constituents from Salvia przewalskii Maxim Natural Product Research and Development 12 2000 27 32
28. M. Xue, Y. Cui, H.Q. Wang, B. Zhang, Y.J. Luo, Y.B. Shi, Z.T. Zhou, and W.J. Xia Identification and determination of phase I metabolites of cryptotanshinone in pigs Asian Journal of Drug Metabolism and Pharmacokinetics 2 2002 271 276
29. H. Wang, X.M. Gao, and B.L. Zhang Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells Journal of Ethnopharmacology 99 2005 93 98
30. L.J. Wang, X.R. Li, Y.H. Li, Y.X. Xu, and M. Xue Study on antiinflammatory effect of danxiongfang prescription Herald of Medicine 27 2008 1022 1024
31. T.H. Wilson, and G. Wiseman The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface Journal of Physiology 123 1954 116 125
32. L. Wu, X.R. Li, Y.H. Li, L.J. Wang, Y. Tang, and M. Xue Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide Journal of Ethnopharmacology 126 2009 197 206
33. F.Q. Zhang, P.L. Lv, and Y. Lan Research progress of Salvia przewalskii Maxim Modern Chinese Medicine 10 2008 13 14