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Volumn 20, Issue 24, 2012, Pages 7101-7111
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Synthesis and biological evaluation of new fluorine substituted derivatives as angiotensin II receptor antagonists with anti-hypertension and anti-tumor effects
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Author keywords
Angiotensin II receptor antagonist; Anti hypertension; Anti tumor; Prostate cancer; Synthesis
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Indexed keywords
2 BUTYL 1 [(2' CARBOXY 4' FLUOROBIPHENYL 4 YL)METHYL] 4 CHLORO 1H IMIDAZOLE 5 CARBOXYLIC ACID;
2 BUTYL 1 [(2' CARBOXY 4',5' DIFLUOROBIPHENYL 4 YL)METHYL] 4 CHLORO 1H IMIDAZOLE 5 CARBOXYLIC ACID;
2 BUTYL 1 [(2' CARBOXY 5' FLUOROBIPHENYL 4 YL)METHYL] 4 CHLORO 1H IMIDAZOLE 5 CARBOXYLIC ACID;
4' [(2 BUTYL 4 CHLORO 5 HYDROXY 1H IMIDAZOLE 1 YL)METHYL] 4 FLUOROBIPHENYL 2 CARBOXYLIC ACID;
4' [(2 BUTYL 4 OXO 1,3 DIAZASPIRO[4.4]NON 1 EN 3 YL)METHYL] 4 FLUOROBIPHENYL 2 CARBOXYLIC ACID;
4' [[N (1 CARBOXY 2 METHYLPROPYL)BUTYRAMIDO]METHYL] 4 FLUOROBIPHENYL 2 CARBOXYLIC ACID;
ANGIOTENSIN 1 RECEPTOR;
ANGIOTENSIN RECEPTOR;
ANGIOTENSIN RECEPTOR ANTAGONIST;
FLUORINE DERIVATIVE;
IRBESARTAN;
LOSARTAN;
UNCLASSIFIED DRUG;
VALSARTAN;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTIHYPERTENSIVE ACTIVITY;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER INHIBITION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DOSE RESPONSE;
DRUG CONFORMATION;
DRUG DESIGN;
DRUG RECEPTOR BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ESSENTIAL HYPERTENSION;
IC 50;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
MOUSE;
NONHUMAN;
PROSTATE CARCINOMA;
RAT;
RECEPTOR AFFINITY;
RENOVASCULAR HYPERTENSION;
ANGIOTENSIN RECEPTOR ANTAGONISTS;
ANIMALS;
ANTIHYPERTENSIVE AGENTS;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
HUMANS;
HYDROCARBONS, FLUORINATED;
HYPERTENSION;
MALE;
MICE;
MICE, NUDE;
PROSTATIC NEOPLASMS;
RATS;
RATS, INBRED SHR;
RATS, SPRAGUE-DAWLEY;
STRUCTURE-ACTIVITY RELATIONSHIP;
XENOGRAFT MODEL ANTITUMOR ASSAYS;
RATTUS;
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EID: 84870055812
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.09.065 Document Type: Article |
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Times cited : (21)
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References (18)
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