Burn Injury Triggered Dysfunction in Dendritic Cell Response to TLR9 Activation and Resulted in Skewed T Cell Functions

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Shen, Haitao ^a,b,c   de Almeida, Patricia E ^a   Kang, Kyung H ^a   Yao, Pamela ^b   Chan, Camie W ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN NORTHERN CALIFORNIA   (United States)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURN; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; IMMUNOREACTIVITY; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ANIMALS; BURNS; CELL DIFFERENTIATION; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MICE; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TH1 CELLS; TH17 CELLS; TOLL-LIKE RECEPTOR 9;

MUS;

EID: 84870028447     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050238     Document Type: Article

References (49)

1. Hoover L, Bochicchio GV, Napolitano LM, Joshi M, Bochicchio K, et al. (2006) Systemic inflammatory response syndrome and nosocomial infection in trauma. J Trauma 61: 310-316; discussion 316-317.
2. Sauaia A, Moore FA, Moore EE, Lezotte DC, (1996) Early risk factors for postinjury multiple organ failure. World J Surg 20: 392-400.
3. Loose LD, Megirian R, Turinsky J, (1984) Biochemical and functional alterations in macrophages after thermal injury. Infect Immun 44: 554-558.
4. Rodeberg DA, Meyer JG, Babcock GF, (1999) Heat shock response: presence and effects in burn patient neutrophils. J Leukoc Biol 66: 773-780.
5. Calum H, Moser C, Jensen PO, Christophersen L, Maling DS, et al. (2009) Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection. Clin Exp Immunol 156: 102-110.
6. Winslow GA, Shelby J, Nelson EW, Saffle JR, (1996) Influence of allogeneic blood transfusion on natural killer cell activity in burn-injured mice. J Burn Care Rehabil 17: 117-123.
7. Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA, (1997) Anti-interleukin-10 antibody restores burn-induced defects in T-cell function. Surgery 122: 146-152.
8. Kelly JL, O'Suilleabhain CB, Soberg CC, Mannick JA, Lederer JA, (1999) Severe injury triggers antigen-specific T-helper cell dysfunction. Shock 12: 39-45.
9. Lederer JA, Rodrick ML, Mannick JA, (1999) The effects of injury on the adaptive immune response. Shock 11: 153-159.
10. Hultman CS, Cairns BA, deSerres S, Frelinger JA, Meyer AA (1995) Early, complete burn wound excision partially restores cytotoxic T lymphocyte function. Surgery 118: 421-429; discussion 429-430.
11. Guo Z, Kavanagh E, Zang Y, Dolan SM, Kriynovich SJ, et al. (2003) Burn injury promotes antigen-driven Th2-type responses in vivo. J Immunol 171: 3983-3990.
12. Teodorczyk-Injeyan JA, Sparkes BG, Falk RE, Peters WJ, Mills GB, (1988) Interleukin-2 secretion and transmembrane signalling in burned patients. J Trauma 28: 152-157.
13. Villadangos JA, Schnorrer P, (2007) Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol 7: 543-555.
14. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, et al. (1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284: 1835-1837.
15. Santini SM, Lapenta C, Logozzi M, Parlato S, Spada M, et al. (2000) Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J Exp Med 191: 1777-1788.
16. Lande R, Gilliet M, (2010) Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann N Y Acad Sci 1183: 89-103.
17. Di Pucchio T, Chatterjee B, Smed-Sorensen A, Clayton S, Palazzo A, et al. (2008) Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I. Nat Immunol. 9: 551-557.
18. Swiecki M, Gilfillan S, Vermi W, Wang Y, Colonna M, (2010) Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity 33: 955-966.
19. Chan CW, Crafton E, Fan HN, Flook J, Yoshimura K, et al. (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 12: 207-213.
20. Pletneva M, Fan H, Park JJ, Radojcic V, Jie C, et al. (2009) IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity. Cancer Res 69: 6607-6614.
21. GeurtsvanKessel CH, Bergen IM, Muskens F, Boon L, Hoogsteden HC, et al. (2009) Both conventional and interferon killer dendritic cells have antigen-presenting capacity during influenza virus infection. PLoS One 4: e7187.
22. Kumar H, Kawai T, Akira S, (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30: 16-34.
23. Schurr JR, Young E, Byrne P, Steele C, Shellito JE, et al. (2005) Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun 73: 532-545.
24. Magnusson M, Tobes R, Sancho J, Pareja E, (2007) Cutting edge: natural DNA repetitive extragenic sequences from gram-negative pathogens strongly stimulate TLR9. J Immunol 179: 31-35.
25. Bhan U, Ballinger MN, Zeng X, Newstead MJ, Cornicelli MD, et al. (2010) Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One 5: e9896.
26. Gilliet M, Cao W, Liu YJ, (2008) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 8: 594-606.
27. Loof TG, Goldmann O, Medina E, (2008) Immune recognition of Streptococcus pyogenes by dendritic cells. Infect Immun 76: 2785-2792.
28. Carvalho NB, Oliveira FS, Duraes FV, de Almeida LA, Florido M, et al. (2011) Toll-Like Receptor 9 Is Required for Full Host Resistance to Mycobacterium avium Infection but Plays No Role in Induction of Th1 Responses. Infect Immun 79: 1638-1646.
29. Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, et al. (2003) Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol 171: 1473-1483.
30. Proietto AI, Lahoud MH, Wu L, (2008) Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 86: 700-708.
31. Fujimi S, Lapchak PH, Zang Y, MacConmara MP, Maung AA, et al. (2009) Murine dendritic cell antigen-presenting cell function is not altered by burn injury. J Leukoc Biol 85: 862-870.
32. Patenaude J, D'Elia M, Hamelin C, Bernier J, (2010) Selective effect of burn injury on splenic CD11c(+) dendritic cells and CD8alpha(+)CD4(-)CD11c(+) dendritic cell subsets. Cell Mol Life Sci 67: 1315-1329.
33. Kawasaki T, Choudhry MA, Schwacha MG, Fujimi S, Lederer JA, et al. (2008) Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process. Am J Physiol Cell Physiol 294: C754-764.
34. van den Berg LM, de Jong MA, Witte L, Ulrich MM, Geijtenbeek TB, (2011) Burn injury suppresses human dermal dendritic cell and Langerhans cell function. Cell Immunol 268: 29-36.
35. D'Arpa N, D'Amelio L, Accardo-Palumbo A, Pileri D, Mogavero R, et al. (2009) Skin dendritic cells in burn patients. Ann Burns Fire Disasters 22: 175-178.
36. D'Arpa A, Accardo-Palumbo A, Amato G, D'Amelio L, Napoli B, et al. (2007) Decrease of circulating dendritic cells in burn patients. Ann Burns Fire Disasters 20: 199-202.
37. Bohannon J, Cui W, Sherwood E, Toliver-Kinsky T, (2010) Dendritic cell modification of neutrophil responses to infection after burn injury. J Immunol 185: 2847-2853.
38. Lin L, Ibrahim AS, Xu X, Farber JM, Avanesian V, et al. (2009) Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog 5: e1000703.
39. Liu J, Feng Y, Yang K, Li Q, Ye L, et al. (2010) Early production of IL-17 protects against acute pulmonary Pseudomonas aeruginosa infection in mice. FEMS Immunol Med Microbiol.
40. Alli RS, Khar A, (2004) Interleukin-12 secreted by mature dendritic cells mediates activation of NK cell function. FEBS Lett 559: 71-76.
41. Van Kaer L, (2007) NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol 19: 354-364.
42. Moreno SE, Alves-Filho JC, Alfaya TM, da Silva JS, Ferreira SH, et al. (2006) IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J Immunol 177: 3218-3224.
43. Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, et al. (2008) IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 105: 18460-18465.
44. Dalpke A, Frank J, Peter M, Heeg K, (2006) Activation of toll-like receptor 9 by DNA from different bacterial species. Infect Immun 74: 940-946.
45. Sjolinder H, Mogensen TH, Kilian M, Jonsson AB, Paludan SR, (2008) Important role for Toll-like receptor 9 in host defense against meningococcal sepsis. Infect Immun 76: 5421-5428.
46. Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, et al. (2007) Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol 9: 633-644.
47. Carvalho NB, Oliveira FS, Duraes FV, de Almeida LA, Florido M, et al. (2011) TLR9 Is Required For Full Host Resistance to Mycobacterium avium Infection But Plays No Role in Induction of Th1 Responses. Infect Immun.
48. Yoneyama H, Matsuno K, Toda E, Nishiwaki T, Matsuo N, et al. (2005) Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J Exp Med 202: 425-435.
49. Gigley JP, Khan IA, (2011) Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection. PLoS One 6: e20838.