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Volumn 18, Issue 49, 2012, Pages 15772-15781

Amycolamicin: A novel broad-spectrum antibiotic inhibiting bacterial topoisomerase

(22) Sawa, Ryuichi a Takahashi, Yoshiaki b Hashizume, Hideki a Sasaki, Kazushige b Ishizaki, Yoshimasa a Umekita, Maya a Hatano, Masaki a Abe, Hikaru a Watanabe, Takumi a Kinoshita, Naoko a Homma, Yoshiko a Hayashi, Chigusa a Inoue, Kunio a Ohba, Syunichi c Masuda, Toru c Arakawa, Masayuki a Kobayashi, Yoshihiko b Hamada, Masa a Igarashi, Masayuki a Adachi, Hayamitsu a more..

a INSTITUTE OF MICROBIAL CHEMISTRY (Japan)

b Institute of Microbial Chemistry (BIKAKEN) Hiyoshi (Japan)

c Institute of Microbial Chemistry (BIKAKEN) Numazu (Japan)

Author keywords

antibiotics; DNA replication; natural products; structure elucidation

Indexed keywords

ABSOLUTE STRUCTURE; ANOMERIZATION; ANTIBACTERIAL DRUGS; BINDING MODES; BROAD SPECTRUM ANTIBIOTICS; CHEMICAL DEGRADATION; DNA GYRASES; DNA REPLICATIONS; EQUILIBRIUM STRUCTURES; HUMAN TOPOISOMERASE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; NATURAL PRODUCTS; NOVOBIOCIN; PATHOGENIC BACTERIUM; PYRANOSE; SELECTION PRESSURES; SELECTIVE INHIBITORS; STRUCTURE ELUCIDATION; TETRAMIC ACIDS; TOPOISOMERASES;

ANTIBIOTICS; BACTERIA; BINDING ENERGY; CARBOXYLIC ACIDS; CHEMICAL MODIFICATION; FUNCTIONAL GROUPS; METHANOL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC SOLVENTS;

DNA;

AMYCOLAMICIN; ANTIINFECTIVE AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; GLUCOSIDE; PYRROLE DERIVATIVE;

ARTICLE; BACTERIUM; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MICROBIAL SENSITIVITY TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTI-BACTERIAL AGENTS; BACTERIA; DNA GYRASE; DNA TOPOISOMERASE IV; GLUCOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; PYRROLES;

EID: 84870024615 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201202645 Document Type: Article

Times cited : (42)

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