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Volumn 7263 LNAI, Issue , 2012, Pages 124-131

MKL-based sample enrichment and customized outcomes enable smaller AD clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; CLINICAL TRIAL; DRUG DEVELOPMENT CYCLE; HIGHER EFFICIENCY; IMAGING MODALITY; MACHINE LEARNING METHODS; MULTI-KERNEL; PREDICTIVE ABILITIES; REDUCED COST; SAMPLE ENRICHMENT; SAMPLE SIZES;

EID: 84870013120     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-642-34713-9_16     Document Type: Conference Paper
Times cited : (5)

References (17)
  • 1
    • 58149386194 scopus 로고    scopus 로고
    • Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: Results from ADNI
    • Misra, C., Fan, Y., Davatzikos, C.: Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: Results from ADNI. Neuroimage 44(4), 1415-1422 (2008)
    • (2008) Neuroimage , vol.44 , Issue.4 , pp. 1415-1422
    • Misra, C.1    Fan, Y.2    Davatzikos, C.3
  • 2
    • 67651171190 scopus 로고    scopus 로고
    • Neural correlates of alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients
    • Schroeter, M.L., Stein, T., Maslowski, N., Neumann, J.: Neural correlates of alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients. Neuroimage 47(4), 1196-1206 (2009)
    • (2009) Neuroimage , vol.47 , Issue.4 , pp. 1196-1206
    • Schroeter, M.L.1    Stein, T.2    Maslowski, N.3    Neumann, J.4
  • 3
    • 67749130881 scopus 로고    scopus 로고
    • Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: The SPARE-AD index
    • Davatzikos, C., Xu, F., An, Y., Fan, Y., Resnick, S.M.: Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain 132(8), 2026-2035 (2009)
    • (2009) Brain , vol.132 , Issue.8 , pp. 2026-2035
    • Davatzikos, C.1    Xu, F.2    An, Y.3    Fan, Y.4    Resnick, S.M.5
  • 5
    • 79551576499 scopus 로고    scopus 로고
    • Predictive markers for AD in a multimodality framework: An analysis of MCI progression in the ADNI population
    • Hinrichs, C., Singh, V., Xu, G., Johnson, S.C.: Predictive markers for AD in a multimodality framework: An analysis of MCI progression in the ADNI population. Neuroimage 55(2), 574-589 (2011)
    • (2011) Neuroimage , vol.55 , Issue.2 , pp. 574-589
    • Hinrichs, C.1    Singh, V.2    Xu, G.3    Johnson, S.C.4
  • 6
    • 79952073234 scopus 로고    scopus 로고
    • Multimodal Classification of Alzheimer's Disease and Mild Cognitive Impairment
    • Zhang, D., Wang, Y., Zhou, L., Yuan, H., Shen, D.: Multimodal Classification of Alzheimer's Disease and Mild Cognitive Impairment. NeuroImage 55(3), 856-867 (2011)
    • (2011) NeuroImage , vol.55 , Issue.3 , pp. 856-867
    • Zhang, D.1    Wang, Y.2    Zhou, L.3    Yuan, H.4    Shen, D.5
  • 8
    • 25444442819 scopus 로고    scopus 로고
    • Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?
    • Visser, P.J., Scheltens, P., Verhey, F.R.J.: Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease? Journal of Neurology, Neurosurgery & Psychiatry 76(10), 1348 (2005)
    • (2005) Journal of Neurology, Neurosurgery & Psychiatry , vol.76 , Issue.10 , pp. 1348
    • Visser, P.J.1    Scheltens, P.2    Verhey, F.R.J.3
  • 9
    • 20344381835 scopus 로고    scopus 로고
    • Donepezil and vitamin E in the treatment of mild cognitive impairment
    • Petersen, R.C., Thomas, R.G., Grundman, M., et al.: Donepezil and vitamin E in the treatment of mild cognitive impairment. N. Engl. J. Med. 352, 2379-2388 (2005)
    • (2005) N. Engl. J. Med. , vol.352 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 11
    • 69249231987 scopus 로고    scopus 로고
    • Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with TBM: An ADNI study of 515 subjects
    • Hua, X., Lee, S., Yanovsky, I., Leow, A.D., et al.: Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with TBM: An ADNI study of 515 subjects. Neuroimage 48(4), 668-681 (2009)
    • (2009) Neuroimage , vol.48 , Issue.4 , pp. 668-681
    • Hua, X.1    Lee, S.2    Yanovsky, I.3    Leow, A.D.4
  • 12
    • 34249753618 scopus 로고
    • Support-vector networks
    • Cortes, C., Vapnik, V.: Support-vector networks. Machine Learning 20(3), 273-297 (1995)
    • (1995) Machine Learning , vol.20 , Issue.3 , pp. 273-297
    • Cortes, C.1    Vapnik, V.2
  • 15
    • 33144484244 scopus 로고    scopus 로고
    • Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's and Dementia
    • Mueller, S.G., Weiner, M.W., Thal, L.J., Petersen, R.C., et al.: Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimer's and Dementia: The Journal of the Alzheimer's Association 1(1), 55-66 (2005)
    • (2005) The Journal of the Alzheimer's Association , vol.1 , Issue.1 , pp. 55-66
    • Mueller, S.G.1    Weiner, M.W.2    Thal, L.J.3    Petersen, R.C.4
  • 16
    • 77953994020 scopus 로고    scopus 로고
    • Reduced sample sizes for atrophy outcomes in alzheimer's disease trials: Baseline adjustment
    • Schott, J.M., Bartlett, J.W., Barnes, J., Leung, K.K., Ourselin, S., Fox, N.C.: Reduced sample sizes for atrophy outcomes in alzheimer's disease trials: baseline adjustment. Neurobiology of Aging 31(8), 1452-1462 (2010)
    • (2010) Neurobiology of Aging , vol.31 , Issue.8 , pp. 1452-1462
    • Schott, J.M.1    Bartlett, J.W.2    Barnes, J.3    Leung, K.K.4    Ourselin, S.5    Fox, N.C.6
  • 17
    • 79951908346 scopus 로고    scopus 로고
    • A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease
    • Zhang, R.Y., Leon, A.C., Chuang-Stein, C., Romano, S.J.: A new proposal for randomized start design to investigate disease-modifying therapies for Alzheimer disease. Clinical Trials 8(1), 5 (2011)
    • (2011) Clinical Trials , vol.8 , Issue.1 , pp. 5
    • Zhang, R.Y.1    Leon, A.C.2    Chuang-Stein, C.3    Romano, S.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.