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Volumn 13, Issue 15, 2012, Pages 1671-1673

Current status of clopidogrel pharmacogenomics

Author keywords

acute coronary syndrome; antiaggregant; bioinformatics; clopidogrel; genetic testing; pharmacogenetics; pharmacogenomics; predictive algorithms

Indexed keywords

ACETYLSALICYLIC ACID; CANGRELOR; CILOSTAZOL; CLOPIDOGREL; CYTOCHROME P450 2C19; ILOPROST; PLACEBO; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; TICAGRELOR;

EID: 84870002919     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.12.153     Document Type: Review
Times cited : (9)

References (22)
  • 1
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J. Am. Coll. Cardiol. 56(12), 919-933 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , Issue.12 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 2
    • 77952075376 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness and risk of cardiovascular morbidity: An updated meta-analysis
    • Sofi F, Marcucci R, Gori AM, Giusti B, Abbate R, Gensini GF. Clopidogrel nonresponsiveness and risk of cardiovascular morbidity: an updated meta-analysis. Thromb. Haemost. 103(4), 841-848 (2010).
    • (2010) Thromb. Haemost. , vol.103 , Issue.4 , pp. 841-848
    • Sofi, F.1    Marcucci, R.2    Gori, A.M.3    Giusti, B.4    Abbate, R.5    Gensini, G.F.6
  • 3
    • 80053080512 scopus 로고    scopus 로고
    • High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI
    • Parodi G, Marcucci R, Valenti R et al. High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI. JAMA 306(11), 1215-1223 (2011).
    • (2011) JAMA , vol.306 , Issue.11 , pp. 1215-1223
    • Parodi, G.1    Marcucci, R.2    Valenti, R.3
  • 5
    • 84858430231 scopus 로고    scopus 로고
    • Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: The role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven
    • Krishna V, Diamond GA, Kaul S. Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: the role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven. Circulation 125(10), 1288-1303 (2012).
    • (2012) Circulation , vol.125 , Issue.10 , pp. 1288-1303
    • Krishna, V.1    Diamond, G.A.2    Kaul, S.3
  • 6
    • 84858407916 scopus 로고    scopus 로고
    • Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: Platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents
    • Gurbel PA, Tantry US. Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents. Circulation 125(10), 1276-1287 (2012).
    • (2012) Circulation , vol.125 , Issue.10 , pp. 1276-1287
    • Gurbel, P.A.1    Tantry, U.S.2
  • 8
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 9
    • 38449103046 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10+12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients
    • DOI 10.1097/FPC.0b013e3282f1b2be, PII 0121301120071200000006
    • Giusti B, Gori AM, Marcucci R et al. Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients. Pharmacogenet. Genomics 17, 1057-1064 (2007). (Pubitemid 351339490)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.12 , pp. 1057-1064
    • Giusti, B.1    Gori, A.M.2    Marcucci, R.3    Saracini, C.4    Sestini, I.5    Paniccia, R.6    Valente, S.7    Antoniucci, D.8    Abbate, R.9    Gensini, G.F.10
  • 10
    • 78049433100 scopus 로고    scopus 로고
    • Effects of CYP2C19 genotype on outcomes of clopidogrel treatment
    • Paré G, Mehta SR, Yusuf S et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N. Engl. J. Med. 363(18), 1704-1714 (2010).
    • (2010) N. Engl. J. Med , vol.363 , Issue.18 , pp. 1704-1714
    • Paré, G.1    Mehta, S.R.2    Yusuf, S.3
  • 11
    • 79957472412 scopus 로고    scopus 로고
    • Cytochrome P4502C19 2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: A meta-analysis
    • Sofi F, Giusti B, Marcucci R, Gori AM, Abbate R, Gensini GF. Cytochrome P4502C19 2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis. Pharmacogenomics J. 11(3), 199-206 (2011).
    • (2011) Pharmacogenomics J. , vol.11 , Issue.3 , pp. 199-206
    • Sofi, F.1    Giusti, B.2    Marcucci, R.3    Gori, A.M.4    Abbate, R.5    Gensini, G.F.6
  • 12
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C192 loss-of-function allele or proton pump inhibitor coadministration: A systematic meta-analysis
    • Hulot JS, Collet JP, Silvain J et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C192 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis. J. Am. Coll. Cardiol. 56(2), 134-143 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , Issue.2 , pp. 134-143
    • Hulot, J.S.1    Collet, J.P.2    Silvain, J.3
  • 13
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 304(16), 1821-1830 (2010).
    • (2010) JAMA , vol.304 , Issue.16 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 14
    • 84555195438 scopus 로고    scopus 로고
    • CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: A systematic review and meta-analysis
    • Holmes MV, Perel P, Shah T, Hingorani AD, Casas JP. CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis. JAMA 306(24), 2704-2714 (2011).
    • (2011) JAMA , vol.306 , Issue.24 , pp. 2704-2714
    • Holmes, M.V.1    Perel, P.2    Shah, T.3    Hingorani, A.D.4    Casas, J.P.5
  • 15
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing D, Koch W, Gebhard D et al. Cytochrome 2C19 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 121(4), 512-518 (2010).
    • (2010) Circulation , vol.121 , Issue.4 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 16
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet 376(9749), 1312-1319 (2010).
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 17
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 376(9749), 1320-1328 (2010).
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 18
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efficacy
    • Bouman HJ, Schömig E, van Werkum JW et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat. Med. 17(1), 110-116 (2011).
    • (2011) Nat. Med , vol.17 , Issue.1 , pp. 110-116
    • Bouman, H.J.1    Schömig, E.2    Van Werkum, J.W.3
  • 19
    • 80054919425 scopus 로고    scopus 로고
    • Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis
    • Cayla G, Hulot JS, O'Connor SA et al. Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis. JAMA 306(16), 1765-1774 (2011).
    • (2011) JAMA , vol.306 , Issue.16 , pp. 1765-1774
    • Cayla, G.1    Hulot, J.S.2    O'connor, S.A.3
  • 20
    • 84860538806 scopus 로고    scopus 로고
    • Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): A prospective, randomised, proof-of-concept trial
    • Roberts JD, Wells GA, Le May MR et al. Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Lancet 379(9827), 1705-1711 (2012).
    • (2012) Lancet , vol.379 , Issue.9827 , pp. 1705-1711
    • Roberts, J.D.1    Wells, G.A.2    Le May, M.R.3
  • 21
    • 79958110089 scopus 로고    scopus 로고
    • Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome
    • Campo G, Parrinello G, Ferraresi P et al. Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome. J. Am. Coll. Cardiol. 57(25), 2474-2483 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.57 , Issue.25 , pp. 2474-2483
    • Campo, G.1    Parrinello, G.2    Ferraresi, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.