메뉴 건너뛰기




Volumn 47, Issue 11, 2012, Pages 386-389

Dimethyl fiimarate: A fumaric acid ester under investigation for the treatment of relapsing-remitting multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

FUMADERM; FUMARIC ACID DIMETHYL ESTER; PLACEBO;

EID: 84869803257     PISSN: 1082801X     EISSN: 19381166     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (30)
  • 1
    • 84870770708 scopus 로고    scopus 로고
    • Neurological disorders: A public health approach
    • World Health Organization. Geneva, Switzerland: WHO Press, Accessed September 12,2012
    • Neurological disorders: A public health approach. In: Neurobgical Disorders: Public Health Challenges. World Health Organization. Geneva, Switzerland: WHO Press; 2007. http://www.who.int/mental_health/neurology/neurodiso/en/index.html. Accessed September 12,2012.
    • (2007) Neurobgical Disorders: Public Health Challenges
  • 2
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502-1517.
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 3
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology. 1996; 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 4
    • 0037154192 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines
    • Goodin DS, Frohman EM, Garmany GP Jr., et al. Disease modifying therapies in multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology. 2002;58:169-178.
    • (2002) Neurology , vol.58 , pp. 169-178
    • Goodin, D.S.1    Frohman, E.M.2    Garmany Jr., G.P.3
  • 5
    • 84870766005 scopus 로고    scopus 로고
    • Drugs@FDA. Gilenya (fingolimod) package insert. Basel, Switzerland: Novartis; revised May 2012, Accessed September 12, 2012
    • Drugs@FDA. Gilenya (fingolimod) package insert. Basel, Switzerland: Novartis; revised May 2012. http://www.accessdata.fda.gov/drugsatf-da_docs/label/2012/022527s0081bl.pdf. Accessed September 12,2012.
  • 6
    • 84870756526 scopus 로고    scopus 로고
    • FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod), Accessed September 12,2012
    • FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod). http://www.fda.gov/Drugs/DrugSafety/ucm303192.htm. Accessed September 12,2012.
  • 7
    • 77949374589 scopus 로고    scopus 로고
    • BG-00012-A novel oral therapy in development for the treatment of multiple sclerosis
    • Fox RJ. BG-00012-A novel oral therapy in development for the treatment of multiple sclerosis. Eur Neurol Rev. 2008;3:100-103.
    • (2008) Eur Neurol Rev , vol.3 , pp. 100-103
    • Fox, R.J.1
  • 9
    • 22244480985 scopus 로고    scopus 로고
    • Adis R&D profile. BG 12: BG 00012, BG 12/ oral fumarate, FAG-201, second-generation fumarate derivative-Fumapharm/Biogen Idee
    • Adis R&D profile. BG 12: BG 00012, BG 12/ oral fumarate, FAG-201, second-generation fumarate derivative-Fumapharm/Biogen Idee. Drug RD. 2005;6:229-230.
    • (2005) Drug RD , vol.6 , pp. 229-230
  • 10
    • 84863203007 scopus 로고    scopus 로고
    • New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis
    • Fox EJ, Rhoades RW. New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis. Curr Opin Neurol. 2012; 25 Suppl: Sll-S19.
    • (2012) Curr Opin Neurol , Issue.25 SUPPL.
    • Fox, E.J.1    Rhoades, R.W.2
  • 11
    • 51649088304 scopus 로고    scopus 로고
    • Activation of Nrf2 and modulation of disease progression in EAE models by BG00012 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities
    • Abstract P503
    • Lukashev M, Zeng W, Goelz S, et al. Activation of Nrf2 and modulation of disease progression in EAE models by BG00012 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities. Abstract P503. Mult Scler. 2007;13(2 Suppl):S149.
    • (2007) Mult Scler , vol.13 , Issue.2 SUPPL.
    • Lukashev, M.1    Zeng, W.2    Goelz, S.3
  • 12
    • 0030828067 scopus 로고    scopus 로고
    • Influence of monomethylfumarate on monocytic cytokine formation-Explanation for adverse and therapeutic effects in psoriasis?
    • Asadullah K, Schmid H, Friedrich M, et al. Influence of monomethylfumarate on monocytic cytokine formation-Explanation for adverse and therapeutic effects in psoriasis? Arch Dermatol Res. 1997;289:623-630.
    • (1997) Arch Dermatol Res , vol.289 , pp. 623-630
    • Asadullah, K.1    Schmid, H.2    Friedrich, M.3
  • 13
    • 0029846154 scopus 로고    scopus 로고
    • Selective stimulation of T helper 2 cytokine response by the anti-psoriasis agent monomethylfumarate
    • de Jong R, Bezemer AC, Zomerdijk TP, et al. Selective stimulation of T helper 2 cytokine response by the anti-psoriasis agent monomethylfumarate. Eur J Immunol. 1996;26:2067-2074.
    • (1996) Eur J Immunol , vol.26 , pp. 2067-2074
    • de Jong, R.1    Bezemer, A.C.2    Zomerdijk, T.P.3
  • 14
    • 33745162188 scopus 로고    scopus 로고
    • Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
    • Schilling S, Goelz S, Linker R, Luehder F, Gold R. Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. Clin Exp Immunol. 2006;145:101-107.
    • (2006) Clin Exp Immunol , vol.145 , pp. 101-107
    • Schilling, S.1    Goelz, S.2    Linker, R.3    Luehder, F.4    Gold, R.5
  • 15
    • 13644268144 scopus 로고    scopus 로고
    • Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    • Li J, Johnson D, Calkins M, et al. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. ToxicolSci. 2005;83:313-328.
    • (2005) ToxicolSci , vol.83 , pp. 313-328
    • Li, J.1    Johnson, D.2    Calkins, M.3
  • 16
    • 31444447800 scopus 로고    scopus 로고
    • Activation of the Keapl/Nrf2 pathway for neuroprotection by electrophilic phase II inducers
    • Satoh T, Okamoto SI, Cui J, et al. Activation of the Keapl/Nrf2 pathway for neuroprotection by electrophilic phase II inducers. Proc Natl Acad Sci USA. 2006;103:768-773.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 768-773
    • Satoh, T.1    Okamoto, S.I.2    Cui, J.3
  • 17
    • 21844474290 scopus 로고    scopus 로고
    • Fibroblast growth factor-1 induces heme oxygen-ase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: Consequences for motor neuron survival
    • Vargas MR, Pehar M, Cassina P, et al. Fibroblast growth factor-1 induces heme oxygen-ase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: Consequences for motor neuron survival. J Biol Chem. 2005;280:25571-25579.
    • (2005) J Biol Chem , vol.280 , pp. 25571-25579
    • Vargas, M.R.1    Pehar, M.2    Cassina, P.3
  • 18
  • 19
    • 0032858530 scopus 로고    scopus 로고
    • Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference
    • Mrowietz U, Christophers E, Altmeyer P. Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference. Br J Dermatol. 1999;141:424-429.
    • (1999) Br J Dermatol , vol.141 , pp. 424-429
    • Mrowietz, U.1    Christophers, E.2    Altmeyer, P.3
  • 20
  • 21
    • 54149116366 scopus 로고    scopus 로고
    • Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase lib study
    • BG-12 Phase lib Study Investigators
    • Kappos L, Gold R, Miller DH, et al; BG-12 Phase lib Study Investigators. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase lib study. Lancet. 2008;372:1463-1472.
    • (2008) Lancet , vol.372 , pp. 1463-1472
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 22
    • 78649519285 scopus 로고    scopus 로고
    • Baseline characteristics of patients enrolled in a randomized, multicenter, placebo-controlled and active comparator trial evaluating efficacy and safety of BG-12 in relapsing-remitting multiple sclerosis: The CONFIRM trial
    • Abstract P06.158
    • Fox R, Miller D, Phillips T, et al. Baseline characteristics of patients enrolled in a randomized, multicenter, placebo-controlled and active comparator trial evaluating efficacy and safety of BG-12 in relapsing-remitting multiple sclerosis: The CONFIRM trial. Abstract P06.158. Neurology. 2010;74(9 Suppl 2):A549.
    • (2010) Neurology , vol.74 , Issue.9 SUPPL. 2
    • Fox, R.1    Miller, D.2    Phillips, T.3
  • 24
    • 78649516854 scopus 로고    scopus 로고
    • Baseline characteristics of patients in the DEFINE trial: A randomized, multicenter, double-blind, placebo-controlled, randomized, phase 3 study of BG-12 in relapsing-remitting multiple sclerosis
    • Abstract P06.149
    • Gold R, Arnold D, Kappos L, et al. Baseline characteristics of patients in the DEFINE trial: A randomized, multicenter, double-blind, placebo-controlled, randomized, phase 3 study of BG-12 in relapsing-remitting multiple sclerosis. Abstract P06.149. Neurology. 2010;74(9 Suppl 2):A546-A547.
    • (2010) Neurology , vol.74 , Issue.9 SUPPL. 2
    • Gold, R.1    Arnold, D.2    Kappos, L.3
  • 25
    • 84870737934 scopus 로고    scopus 로고
    • BG-12 increases the proportion of patients free of clinical and radiologic disease activity in relapsing-remitting multiple sclerosis: Findings from the DEFINE study
    • (Meeting Abstracts 1): PD5.005, Accessed September 12, 2012
    • Giovannoni G, Gold R, Kappos L, et al. BG-12 increases the proportion of patients free of clinical and radiologic disease activity in relapsing-remitting multiple sclerosis: Findings from the DEFINE study. Neurology. 2012; 78 (Meeting Abstracts 1): PD5.005. http://www.neurology.org/cgi/content/meeting_abstract/78/l_Meet-ingAbstracts/PD5.005. Accessed September 12, 2012.
    • (2012) Neurology , pp. 78
    • Giovannoni, G.1    Gold, R.2    Kappos, L.3
  • 26
    • 84870754109 scopus 로고    scopus 로고
    • Biogen Idee press release. Oral BG-12 (dimethyl fumarate) significantly reduced multiple sclerosis (MS) relapses and disability progression in DEFINE phase 3 clinical trial. October 21, 2011, Accessed September 12, 2012
    • Biogen Idee press release. Oral BG-12 (dimethyl fumarate) significantly reduced multiple sclerosis (MS) relapses and disability progression in DEFINE phase 3 clinical trial. October 21, 2011. http://www.biogenidec.com/press_release_details.aspx?ID=5981&ReqID=1619878. Accessed September 12, 2012.
  • 27
    • 84870752615 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Long-term safety and efficacy study of oral BG00012 monotherapy in relapsing-remitting multiple sclerosis. NCT00835770, Accessed September 12, 2012
    • ClinicalTrials.gov. Long-term safety and efficacy study of oral BG00012 monotherapy in relapsing-remitting multiple sclerosis. NCT00835770. www.clinicaltrials.gov/ct2/show/NCT00835770?term=BG-12&rank=5. Accessed September 12, 2012.
  • 28
    • 0031973909 scopus 로고    scopus 로고
    • The role of magnetic resonance techniques in understanding and managing multiple sclerosis
    • Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain. 1998;121(Pt l):3-24.
    • (1998) Brain , vol.121 , Issue.PART l , pp. 3-24
    • Miller, D.H.1    Grossman, R.I.2    Reingold, S.C.3    McFarland, H.F.4
  • 29
    • 84863284276 scopus 로고    scopus 로고
    • Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: Subgroup analyses from the phase 2b study
    • Kappos L, Gold R, Miller DH, et al. Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: Subgroup analyses from the phase 2b study. Mult Scler. 2012;18:314-321.
    • (2012) Mult Scler , vol.18 , pp. 314-321
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 30
    • 84870737225 scopus 로고    scopus 로고
    • Safety and tolerability of BG-12 in patients with relapsing-remitting multiple sclerosis (RRMS): Analyses from the CONFIRM study
    • (Meeting Abstracts 1), Accessed September 12, 2012
    • Phillips JT, Fox R, Miller D, et al. Safety and tolerability of BG-12 in patients with relapsing-remitting multiple sclerosis (RRMS): Analyses from the CONFIRM study. Neurology. 2012; 78(Meeting Abstracts 1): S41.005. http://www.neurology.org/cgi/content/meeting_abstract/78/l_MeetingAbstracts/S41.005. Accessed September 12, 2012
    • (2012) Neurology , vol.78
    • Phillips, J.T.1    Fox, R.2    Miller, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.