-
1
-
-
84870770708
-
Neurological disorders: A public health approach
-
World Health Organization. Geneva, Switzerland: WHO Press, Accessed September 12,2012
-
Neurological disorders: A public health approach. In: Neurobgical Disorders: Public Health Challenges. World Health Organization. Geneva, Switzerland: WHO Press; 2007. http://www.who.int/mental_health/neurology/neurodiso/en/index.html. Accessed September 12,2012.
-
(2007)
Neurobgical Disorders: Public Health Challenges
-
-
-
2
-
-
54149084585
-
Multiple sclerosis
-
Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372:1502-1517.
-
(2008)
Lancet
, vol.372
, pp. 1502-1517
-
-
Compston, A.1
Coles, A.2
-
3
-
-
0029913882
-
Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
-
Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology. 1996; 46:907-911.
-
(1996)
Neurology
, vol.46
, pp. 907-911
-
-
Lublin, F.D.1
Reingold, S.C.2
-
4
-
-
0037154192
-
Disease modifying therapies in multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines
-
Goodin DS, Frohman EM, Garmany GP Jr., et al. Disease modifying therapies in multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology. 2002;58:169-178.
-
(2002)
Neurology
, vol.58
, pp. 169-178
-
-
Goodin, D.S.1
Frohman, E.M.2
Garmany Jr., G.P.3
-
5
-
-
84870766005
-
-
Drugs@FDA. Gilenya (fingolimod) package insert. Basel, Switzerland: Novartis; revised May 2012, Accessed September 12, 2012
-
Drugs@FDA. Gilenya (fingolimod) package insert. Basel, Switzerland: Novartis; revised May 2012. http://www.accessdata.fda.gov/drugsatf-da_docs/label/2012/022527s0081bl.pdf. Accessed September 12,2012.
-
-
-
-
6
-
-
84870756526
-
-
FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod), Accessed September 12,2012
-
FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod). http://www.fda.gov/Drugs/DrugSafety/ucm303192.htm. Accessed September 12,2012.
-
-
-
-
7
-
-
77949374589
-
BG-00012-A novel oral therapy in development for the treatment of multiple sclerosis
-
Fox RJ. BG-00012-A novel oral therapy in development for the treatment of multiple sclerosis. Eur Neurol Rev. 2008;3:100-103.
-
(2008)
Eur Neurol Rev
, vol.3
, pp. 100-103
-
-
Fox, R.J.1
-
9
-
-
22244480985
-
-
Adis R&D profile. BG 12: BG 00012, BG 12/ oral fumarate, FAG-201, second-generation fumarate derivative-Fumapharm/Biogen Idee
-
Adis R&D profile. BG 12: BG 00012, BG 12/ oral fumarate, FAG-201, second-generation fumarate derivative-Fumapharm/Biogen Idee. Drug RD. 2005;6:229-230.
-
(2005)
Drug RD
, vol.6
, pp. 229-230
-
-
-
10
-
-
84863203007
-
New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis
-
Fox EJ, Rhoades RW. New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis. Curr Opin Neurol. 2012; 25 Suppl: Sll-S19.
-
(2012)
Curr Opin Neurol
, Issue.25 SUPPL.
-
-
Fox, E.J.1
Rhoades, R.W.2
-
11
-
-
51649088304
-
Activation of Nrf2 and modulation of disease progression in EAE models by BG00012 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities
-
Abstract P503
-
Lukashev M, Zeng W, Goelz S, et al. Activation of Nrf2 and modulation of disease progression in EAE models by BG00012 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities. Abstract P503. Mult Scler. 2007;13(2 Suppl):S149.
-
(2007)
Mult Scler
, vol.13
, Issue.2 SUPPL.
-
-
Lukashev, M.1
Zeng, W.2
Goelz, S.3
-
12
-
-
0030828067
-
Influence of monomethylfumarate on monocytic cytokine formation-Explanation for adverse and therapeutic effects in psoriasis?
-
Asadullah K, Schmid H, Friedrich M, et al. Influence of monomethylfumarate on monocytic cytokine formation-Explanation for adverse and therapeutic effects in psoriasis? Arch Dermatol Res. 1997;289:623-630.
-
(1997)
Arch Dermatol Res
, vol.289
, pp. 623-630
-
-
Asadullah, K.1
Schmid, H.2
Friedrich, M.3
-
13
-
-
0029846154
-
Selective stimulation of T helper 2 cytokine response by the anti-psoriasis agent monomethylfumarate
-
de Jong R, Bezemer AC, Zomerdijk TP, et al. Selective stimulation of T helper 2 cytokine response by the anti-psoriasis agent monomethylfumarate. Eur J Immunol. 1996;26:2067-2074.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2067-2074
-
-
de Jong, R.1
Bezemer, A.C.2
Zomerdijk, T.P.3
-
14
-
-
33745162188
-
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
-
Schilling S, Goelz S, Linker R, Luehder F, Gold R. Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. Clin Exp Immunol. 2006;145:101-107.
-
(2006)
Clin Exp Immunol
, vol.145
, pp. 101-107
-
-
Schilling, S.1
Goelz, S.2
Linker, R.3
Luehder, F.4
Gold, R.5
-
15
-
-
13644268144
-
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
-
Li J, Johnson D, Calkins M, et al. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. ToxicolSci. 2005;83:313-328.
-
(2005)
ToxicolSci
, vol.83
, pp. 313-328
-
-
Li, J.1
Johnson, D.2
Calkins, M.3
-
16
-
-
31444447800
-
Activation of the Keapl/Nrf2 pathway for neuroprotection by electrophilic phase II inducers
-
Satoh T, Okamoto SI, Cui J, et al. Activation of the Keapl/Nrf2 pathway for neuroprotection by electrophilic phase II inducers. Proc Natl Acad Sci USA. 2006;103:768-773.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 768-773
-
-
Satoh, T.1
Okamoto, S.I.2
Cui, J.3
-
17
-
-
21844474290
-
Fibroblast growth factor-1 induces heme oxygen-ase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: Consequences for motor neuron survival
-
Vargas MR, Pehar M, Cassina P, et al. Fibroblast growth factor-1 induces heme oxygen-ase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: Consequences for motor neuron survival. J Biol Chem. 2005;280:25571-25579.
-
(2005)
J Biol Chem
, vol.280
, pp. 25571-25579
-
-
Vargas, M.R.1
Pehar, M.2
Cassina, P.3
-
18
-
-
0141481019
-
Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters
-
Werdenberg D, Joshi R, Wolffram S, Merkle HP, Langguth P. Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters. Biopharm Drug Dispos. 2003;24:259-273.
-
(2003)
Biopharm Drug Dispos
, vol.24
, pp. 259-273
-
-
Werdenberg, D.1
Joshi, R.2
Wolffram, S.3
Merkle, H.P.4
Langguth, P.5
-
19
-
-
0032858530
-
Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference
-
Mrowietz U, Christophers E, Altmeyer P. Treatment of severe psoriasis with fumaric acid esters: Scientific background and guidelines for therapeutic use. The German Fumaric Acid Ester Consensus Conference. Br J Dermatol. 1999;141:424-429.
-
(1999)
Br J Dermatol
, vol.141
, pp. 424-429
-
-
Mrowietz, U.1
Christophers, E.2
Altmeyer, P.3
-
21
-
-
54149116366
-
Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase lib study
-
BG-12 Phase lib Study Investigators
-
Kappos L, Gold R, Miller DH, et al; BG-12 Phase lib Study Investigators. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase lib study. Lancet. 2008;372:1463-1472.
-
(2008)
Lancet
, vol.372
, pp. 1463-1472
-
-
Kappos, L.1
Gold, R.2
Miller, D.H.3
-
22
-
-
78649519285
-
Baseline characteristics of patients enrolled in a randomized, multicenter, placebo-controlled and active comparator trial evaluating efficacy and safety of BG-12 in relapsing-remitting multiple sclerosis: The CONFIRM trial
-
Abstract P06.158
-
Fox R, Miller D, Phillips T, et al. Baseline characteristics of patients enrolled in a randomized, multicenter, placebo-controlled and active comparator trial evaluating efficacy and safety of BG-12 in relapsing-remitting multiple sclerosis: The CONFIRM trial. Abstract P06.158. Neurology. 2010;74(9 Suppl 2):A549.
-
(2010)
Neurology
, vol.74
, Issue.9 SUPPL. 2
-
-
Fox, R.1
Miller, D.2
Phillips, T.3
-
24
-
-
78649516854
-
Baseline characteristics of patients in the DEFINE trial: A randomized, multicenter, double-blind, placebo-controlled, randomized, phase 3 study of BG-12 in relapsing-remitting multiple sclerosis
-
Abstract P06.149
-
Gold R, Arnold D, Kappos L, et al. Baseline characteristics of patients in the DEFINE trial: A randomized, multicenter, double-blind, placebo-controlled, randomized, phase 3 study of BG-12 in relapsing-remitting multiple sclerosis. Abstract P06.149. Neurology. 2010;74(9 Suppl 2):A546-A547.
-
(2010)
Neurology
, vol.74
, Issue.9 SUPPL. 2
-
-
Gold, R.1
Arnold, D.2
Kappos, L.3
-
25
-
-
84870737934
-
BG-12 increases the proportion of patients free of clinical and radiologic disease activity in relapsing-remitting multiple sclerosis: Findings from the DEFINE study
-
(Meeting Abstracts 1): PD5.005, Accessed September 12, 2012
-
Giovannoni G, Gold R, Kappos L, et al. BG-12 increases the proportion of patients free of clinical and radiologic disease activity in relapsing-remitting multiple sclerosis: Findings from the DEFINE study. Neurology. 2012; 78 (Meeting Abstracts 1): PD5.005. http://www.neurology.org/cgi/content/meeting_abstract/78/l_Meet-ingAbstracts/PD5.005. Accessed September 12, 2012.
-
(2012)
Neurology
, pp. 78
-
-
Giovannoni, G.1
Gold, R.2
Kappos, L.3
-
26
-
-
84870754109
-
-
Biogen Idee press release. Oral BG-12 (dimethyl fumarate) significantly reduced multiple sclerosis (MS) relapses and disability progression in DEFINE phase 3 clinical trial. October 21, 2011, Accessed September 12, 2012
-
Biogen Idee press release. Oral BG-12 (dimethyl fumarate) significantly reduced multiple sclerosis (MS) relapses and disability progression in DEFINE phase 3 clinical trial. October 21, 2011. http://www.biogenidec.com/press_release_details.aspx?ID=5981&ReqID=1619878. Accessed September 12, 2012.
-
-
-
-
27
-
-
84870752615
-
-
ClinicalTrials.gov. Long-term safety and efficacy study of oral BG00012 monotherapy in relapsing-remitting multiple sclerosis. NCT00835770, Accessed September 12, 2012
-
ClinicalTrials.gov. Long-term safety and efficacy study of oral BG00012 monotherapy in relapsing-remitting multiple sclerosis. NCT00835770. www.clinicaltrials.gov/ct2/show/NCT00835770?term=BG-12&rank=5. Accessed September 12, 2012.
-
-
-
-
28
-
-
0031973909
-
The role of magnetic resonance techniques in understanding and managing multiple sclerosis
-
Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain. 1998;121(Pt l):3-24.
-
(1998)
Brain
, vol.121
, Issue.PART l
, pp. 3-24
-
-
Miller, D.H.1
Grossman, R.I.2
Reingold, S.C.3
McFarland, H.F.4
-
29
-
-
84863284276
-
Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: Subgroup analyses from the phase 2b study
-
Kappos L, Gold R, Miller DH, et al. Effect of BG-12 on contrast-enhanced lesions in patients with relapsing-remitting multiple sclerosis: Subgroup analyses from the phase 2b study. Mult Scler. 2012;18:314-321.
-
(2012)
Mult Scler
, vol.18
, pp. 314-321
-
-
Kappos, L.1
Gold, R.2
Miller, D.H.3
-
30
-
-
84870737225
-
Safety and tolerability of BG-12 in patients with relapsing-remitting multiple sclerosis (RRMS): Analyses from the CONFIRM study
-
(Meeting Abstracts 1), Accessed September 12, 2012
-
Phillips JT, Fox R, Miller D, et al. Safety and tolerability of BG-12 in patients with relapsing-remitting multiple sclerosis (RRMS): Analyses from the CONFIRM study. Neurology. 2012; 78(Meeting Abstracts 1): S41.005. http://www.neurology.org/cgi/content/meeting_abstract/78/l_MeetingAbstracts/S41.005. Accessed September 12, 2012
-
(2012)
Neurology
, vol.78
-
-
Phillips, J.T.1
Fox, R.2
Miller, D.3
|