Salubrinal Protects Against Cigarette Smoke Extract-induced HBEpC Apoptosis Likely Via Regulating the Activity of PERK-eIF2α Signaling Pathway

Archives of Medical Research

Volumn 43, Issue 7, 2012, Pages 522-529

  Yuan, Ting ^a   Luo, Bai Ling ^a   Wei, Tian Hong ^a   Zhang, Li ^a   He, Bai Mei ^a   Niu, Rui Chao ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; COPD; EIF2 ; Human bronchial epithelial cells; PERK; Salubrinal

Indexed keywords

CASPASE 3; CASPASE 4; CHOLECYSTOKININ OCTAPEPTIDE; CIGARETTE SMOKE; COMPLEMENTARY DNA; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; RNA; SALUBRINAL; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL DEATH; CELL PROTECTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SMOKING; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

APOPTOSIS; BRONCHI; CASPASE 3; CASPASES, INITIATOR; CELL SURVIVAL; CELLS, CULTURED; CINNAMATES; EIF-2 KINASE; EPITHELIAL CELLS; EUKARYOTIC INITIATION FACTOR-2; HOMEOSTASIS; HUMANS; PLANT EXTRACTS; SIGNAL TRANSDUCTION; SMOKE; THIOUREA; TOBACCO;

EID: 84869798280     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2012.10.002     Document Type: Article

References (23)

1. Pauwels R.A., Rabe K.F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 2004, 364:613-620.
2. Pauwels R.A., Buist A.S., Calverley P.M., et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001, 163:1256-1276.
3. Kelsen S.G., Duan X., Ji R., et al. Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach. Am J Respir Cell Mol Biol 2008, 38:541-550.
4. Demedts I.K., Demoor T., Bracke K.R., et al. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res 2006, 7:53.
5. Kuwano K. Epithelial cell apoptosis and lung remodeling. Cell Mol Immunol 2007, 4:419-429.
6. Lindholm D., Wootz H., Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differ 2006, 13:385-392.
7. Zhou J., Liu C.Y., Back S.H., et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci USA 2006, 103:14343-14348.
8. Harding H.P., Zhang Y., Bertolotti A., et al. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000, 5:897-904.
9. Muaddi H., Majumder M., Peidis P., et al. Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell 2010, 21:3220-3231.
10. Fischer H., Koenig U., Eckhart L., et al. Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun 2002, 293:722-726.
11. Hitomi J., Katayama T., Eguchi Y., et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 2004, 165:347-356.
12. Boyce M., Bryant K.F., Jousse C., et al. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005, 307:935-939.
13. Kim I., Xu W., Reed J.C. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008, 7:1013-1030.
14. Bodas M., Min T., Vij N. Early-age-related changes in proteostasis augment immunopathogenesis of sepsis and acute lung injury. PLoS One 2010, 5:e15480.
15. Braber S., Koelink P.J., Henricks P.A., et al. Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. Am J Physiol Lung Cell Mol Physiol 2011, 300:L255-L265.
16. Xiong X.L., Jia R.H., Yang D.P., et al. Irbesartan attenuates contrast media-induced NRK-52E cells apoptosis. Pharmacol Res 2006, 54:253-260.
17. Xu F.F., Liu X.H., Cai L.R. [Role of hypoxia-inducible factor-1alpha in the prevention of cardiomyocyte injury induced by hypoxic preconditioning]. Sheng Li Xue Bao 2004, 56:609-614.
18. Hansel N.N., Sidhaye V., Rafaels N.M., et al. Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. PLoS One 2010, 5:e14226.
19. Min T., Bodas M., Mazur S., et al. Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema. J Mol Med (Berl) 2011, 89:577-593.
20. Barnes P.J. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009, 41:631-638.
21. Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007, 8:519-529.
22. Lee do Y., Lee K.S., Lee H.J., et al. Activation of PERK signaling attenuates Abeta-mediated ER stress. PLoS One 2010, 5:e10489.
23. Sokka A.L., Putkonen N., Mudo G., et al. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. J Neurosci 2007, 27:901-908.