Hypoparathyroidism: From diagnosis to treatment

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 19, Issue 6, 2012, Pages 435-442

  De Sanctis, Vincenzo ^a   Soliman, Ashraf ^b   Fiscina, Bernadette ^c  

^a Quisisana Hospital   (Italy)

^b HAMAD GENERAL HOSPITAL   (Qatar)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

diagnosis; hypocalcaemia; hypoparathyroidism; parathormone; treatment

Indexed keywords

25 HYDROXYVITAMIN D; ALUMINUM HYDROXIDE; CALCITRIOL; CALCIUM; CALCIUM SENSING RECEPTOR; CINACALCET; CREATINE KINASE; DEFEROXAMINE; ESTROGEN; FERRITIN; FUROSEMIDE; GLUCOCORTICOID; GLUCONATE CALCIUM; HYDROCHLOROTHIAZIDE; IODINE 131; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; SEVELAMER; VITAMIN D;

AUTOIMMUNE THYROIDITIS; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CARDIOVASCULAR DISEASE; CLINICAL FEATURE; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; ELECTROCARDIOGRAM; FOLLOW UP; HORMONE ACTION; HORMONE SUBSTITUTION; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; HYPERPHOSPHATEMIA; HYPOCALCEMIA; HYPOPARATHYROIDISM; IRON CHELATION; IRON OVERLOAD; KIDNEY DISEASE; LABORATORY TEST; MOLECULAR GENETICS; MYOPATHY; PARATHYROID TRANSPLANTATION; PATHOGENESIS; POSTOPERATIVE COMPLICATION; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIDE EFFECT; SKIN NECROSIS; STEATORRHEA; SYMPTOM; THYROIDECTOMY; TREATMENT INDICATION; TREATMENT OUTCOME; VITAMIN D INTOXICATION; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; ASCORBIC ACID; BONE RESORPTION; CHILD; FEMALE; HOMEOSTASIS; HUMANS; HYPOCALCEMIA; HYPOPARATHYROIDISM; MALE; PARATHYROID HORMONE; VITAMIN D;

EID: 84869785673     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283591502     Document Type: Review

References (39)

1. Lee JW. Fluid and electrolyte disturbances in critically ill patients. Electrolyte Blood Press 2010; 8:72-81.
2. Bilezikian JP, Khan A, Potts JT Jr, et al. Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. Bone Miner Res 2011; 26:2317-2337.
3. Chehade H, Girardin E, Rosato L, et al. Acute life-threatening presentation of vitamin D deficiency rickets. J Clin Endocrinol Metab 2011; 96:2681-2683.
4. Rubin MR, Bilezikian JP. Hypoparathyroidism: clinical features, skeletal microstructure and parathyroid hormone replacement. Arq Bras Endocrinol Metabol 2010; 54:220-226.
5. Khan MI, Waguespack SG, Hu MI. Medical management of postsurgical hypoparathyroidism. Endocr Pract 2011; 17 (Suppl 1):18-25.
6. De Sanctis V, Giovannini M, Ciccone S, Karimi M. Generalized tonic-clonic seizures in a thalassemic patient with hypoparathyroidism and brain calcinosis. Pediatr Endocrinol Rev 2011; 8 (Suppl 2):334-336.
7. Weiler FG, Dias-da-Silva MR, Lazaretti-Castro M. Autoimmune polyendocrine syndrome type 1: case report and review of literature. Arq Bras Endocrinol Metabol 2012; 56:54-66.
8. Gubellini E, Gamberoni MR, Gilli G, et al. Acquired hypoparathyroidism in thalassaemia: the personal experience from 1954 to 2010 (First part) Riv Ital. Med Asolesc 2011; 9:27-33.
9. Hannan FM, Nesbit MA, Zhang C, et al. Identification of 70 calcium-sensing receptor mutations in hyper-and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites. Hum Mol Genet 2012; 21:2768-2778.
10. Raue F, Pichl J, Dö rr HG, et al. Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia-a German survey. Clin Endocrinol (Oxf) 2011; 75:760-765.
11. Nakajima K, Yamazaki K, Kimura H, et al. Novel gain of function mutations of the calcium sensing receptor in two patients with PTH-deficient hypocalcemia. Intern Med 2009; 48:1951-1956.
12. Brandi ML. Genetics of hypoparathyroidism and pseudohypoparathyroidism. J Endocrinol Invest 2011; 34 (Suppl 7):27-34.
13. Shoback D. Hypoparathyroidism. N Engl J Med 2008; 359:391-403.
14. Patil NJ, Yadav SS, Gokhale YA, Padwa N. Primary hypoparathyroidism: psychosis in postpartum period. J Assoc Physicians India 2010; 58:506-508.
15. Ilveskoski E, Sclarovsky S, Nikus K. Severe hypocalcemia simulating ST-elevation myocardial infarction. Am J Emerg Med 2012; 30:3-6.
16. Bhadada SK, Bhansali A, Upreti V, et al. Spectrum of neurological manifestations of idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neurol India 2011; 59:586-589.
17. Nicolau Ramis J, Ibáñ ez AE, Irigón RR, et al. Extrapyramidal symptoms due to calcinosis cerebri in a patient with unknown primary hypoparathyroidism. Endocrinol Nutr 2012; 59:69-71.
18. Abraham A, Ziv I, Steinmetz A, et al. Autoimmune polyendocrine syndrome type I and brain calcinosis. Parkinsonism Relat Disord 2010; 16:101-110.
19. Roztoczyń ska D, Kroczka S, Kumorowicz-Czoch M, et al. Neurological disorders in patients with hypoparathyroidism. Przegl Lek 2010; 67:1149-1154.
20. Mamdani N, Repp AL, Seyoum B, Berhanu P. Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed. Endocr Pract 2007; 13:487-492.
21. Goswami R, Sharma R, Sreenivas V, et al. Prevalence and progression of basal ganglia calcification and its pathogenic mechanism in patients with idiopathic hypoparathyroidism. Clin Endocrinol (Oxf) 2012; 77:200-206.
22. Ballane GT, Sfeir JG, Dakik HA, et al. Use of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy. Eur J Endocrinol 2012; 166: 1113-1120.
23. Rangel I, Barbosa G, de Sousa C, et al. Hypocalcemia as a reversible cause of heart failure. Rev Port Cardiol 2012; 31:39-41.
24. Gupta P, Tomar M, Radhakrishnan S, Shrivastava S. Hypocalcemic cardiomyopathy presenting as cardiogenic shock. Ann Pediatr Cardiol 2011; 4:152-155.
25. Daher R, Boujaoude J. Digestive manifestations of parathyroid disorders. World J Gastroenterol 2011; 17:4063-4066.
26. Dai CL, Sun ZJ, Zhang X, Qiu M. Elevated muscle enzymes and muscle biopsy in idiopathic hypoparathyroidism patients. J Endocrinol Invest 2012; 35:286-289.
27. Syriou V, Kolitsa A, Pantazi L, Pikazis D. Hypoparathyroidism in a patient presenting with severe myopathy and skin rash. Case report and review of the literature. Hormones (Athens) 2005; 4:161-164.
28. Khan A, Fong J. Hypocalcemia: updates in diagnosis and management for primary care. Can Fam Phys 2012; 58:158-162.
29. Sikjaer T, Rejnmark L, Mosekilde L. PTH treatment in hypoparathyroidism. Curr Drug Saf 2011; 6:89-99.
30. Winer KK, Sinaii N, Peterson D, et al. Effects of once versus twice-daily parathyroid hormone 1-34 therapy in children with hypoparathyroidism. J Clin Endocrinol Metab 2008; 93:3389-3395.
31. Winer KK, Ko CW, Reynolds JC, et al. Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium. J Clin Endocrinol Metab 2003; 88:4214-4220.
32. Winer KK, Zhang B, Shrader JA, et al. Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism. J Clin Endocrinol Metab 2012; 97:391-399.
33. Linglart A, Rothenbuhler A, Gueorgieva I, et al. Long-term results of continuous subcutaneous recombinant PTH (1-34) infusion in children with refractory hypoparathyroidism. J Clin Endocrinol Metab 2011; 96:3308-3312.
34. Theman TA, Collins MT, Dempster DW, et al. PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation. J Bone Miner Res 2009; 24:964-967.
35. D́az-Soto G, Mora-Porta M, Nicolau J, et al. Efficacy and safety of long term treatment of unresponsive hypoparathyroidism using multipulse subcutaneous infusion of teriparatide. Horm Metab Res 2012;44:708-710.
36. Rubin MR, Sliney J Jr, McMahon DJ, et al. Therapy of hypoparathyroidism with intact parathyroid hormone. Osteoporos Int 2010; 21:1927-1934.
37. Letz S, Rus R, Haag C, Dö rr HG. Novel activating mutations of the calciumsensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors. J Clin Endocrinol Metab 2010; 95:229-233.
38. Moffett JM, Suliburk J. Parathyroid autotransplantation. Endocr Pract 2011; 17 (Suppl 1):83-89.
39. Guerrero MA. Cryopreservation of parathyroid glands. Int J Endocrinol 2010; 2010:829540.