Indirect Effect of 7-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Carriage in Newborns in Rural Gambia: A Randomised Controlled Trial

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Egere, Uzochukwu ^a   Townend, John ^a   Roca, Anna ^a,b   Akinsanya, Abiodun ^a   Bojang, Abdoulie ^a   Nsekpong, David ^a   Greenwood, Brian ^c   Adegbola, Richard A ^d   Hill, Philip C ^a,e  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

PNEUMOCOCCUS VACCINE;

ARTICLE; BACTERIUM ISOLATION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GAMBIA; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PNEUMOCOCCAL INFECTION; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; SEROTYPE; SINGLE BLIND PROCEDURE; STREPTOCOCCUS PNEUMONIAE; TREATMENT RESPONSE; VACCINATION;

CARRIER STATE; FEMALE; GAMBIA; HUMANS; INFANT, NEWBORN; KAPLAN-MEIER ESTIMATE; MALE; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; RURAL POPULATION; SEROTYPING; STREPTOCOCCUS PNEUMONIAE; VACCINATION;

STREPTOCOCCUS PNEUMONIAE;

EID: 84869785102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049143     Document Type: Article

References (36)

1. Isaacman DJ, Fletcher MA, Fritzell B, Ciuryla V, Schranz J, (2007) Indirect effects associated with widespread vaccination of infants with heptavalent pneumococcal conjugate vaccine (PCV7; Prevnar). Vaccine 25: 2420-2427.
2. CDC (2005) Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease-United States, 1998-2003. MMWR Morb Mortal Wkly Rep 54: 893-897.
3. Poehling KA, Talbot TR, Griffin MR, Craig AS, Whitney CG, et al. (2006) Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine. JAMA 295: 1668.
4. Black S, Shinefield H, Baxter R, Austrian R, Bracken L, et al. (2004) Postlicensure surveillance for pneumococcal invasive disease after use of heptavalent pneumococcal conjugate vaccine in Northern California Kaiser Permanente. Pediatric Infectious Disease Journal 23: 485-489.
5. Whitney CG, Farley MM, Hadler J, Harrison LH, Bennett NM, et al. (2003) Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N Engl J Med 348: 1737-1746.
6. Whitney CG, Pilishvili T, Farley MM, Schaffner W, Craig AS, et al. (2006) Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. Lancet 368: 1495-1502.
7. Etiology and clinical signs of serious infections in young infants in developing countries: a WHO collaborative study. Pediatr Infect Dis J 18: S1-69.
8. Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, et al. (2003) A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med 349: 1341-1348.
9. Cutts FT, Zaman SM, Enwere G, Jaffar S, Levine OS, et al. (2005) Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial. Lancet 365: 1139-1146.
10. Black S, Shinefield H, Fireman B, Lewis E, Ray P, et al. (2000) Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 19: 187-195.
11. Cheung YB, Zaman SM, Nsekpong ED, Van Beneden CA, Adegbola RA, et al. (2009) Nasopharyngeal Carriage of Streptococcus pneumoniae in Gambian Children who Participated in a 9-valent Pneumococcal Conjugate Vaccine Trial and in Their Younger Siblings. Pediatr Infect Dis J.
12. Roca A, Hill PC, Townend J, Egere U, Antonio M, et al. (2011) Effects of Community-Wide Vaccination with PCV-7 on Pneumococcal Nasopharyngeal Carriage in The Gambia: A Cluster-Randomized Trial. PLoS Med 8: e1001107.
13. Hill PC, Akisanya A, Sankareh K, Cheung YB, Saaka M, et al. (2006) Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers. Clin Infect Dis 43: 673-679.
14. Hill PC, Cheung YB, Akisanya A, Sankareh K, Lahai G, et al. (2008) Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study. Clin Infect Dis 46: 807-814.
15. O'Brien KL, Nohynek H, (2003) Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae. Pediatr Infect Dis J 22: e1-11.
16. Adegbola RA, Hill PC, Secka O, Ikumapayi UN, Lahai G, et al. (2006) Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996-2003. Trop Med Int Health 11: 1128-1135.
17. O'Brien KL, Millar EV, Zell ER, Bronsdon M, Weatherholtz R, et al. (2007) Effect of Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization among Immunized and Unimmunized Children in a Community-Randomized Trial. Journal of Infectious Diseases 196: 1211-1220.
18. Millar EV, Watt JP, Bronsdon MA, Dallas J, Reid R, et al. (2008) Indirect effect of 7-valent pneumococcal conjugate vaccine on pneumococcal colonization among unvaccinated household members. Clinical Infectious Diseases 47: 989-996.
19. Cortese MM, Wolff M, Almeido-Hill J, Reid R, Ketcham J, et al. (1992) High incidence rates of invasive pneumococcal disease in the White Mountain Apache population. Archives of internal medicine 152: 2277.
20. Hussain M, Melegaro A, Pebody RG, George R, Edmunds WJ, et al. (2005) A longitudinal household study of Streptococcus pneumoniae nasopharyngeal carriage in a UK setting. Epidemiol Infect 133: 891-898.
21. Hill PC, Townend J, Antonio M, Akisanya B, Ebruke C, et al. Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study. Clin Infect Dis 50: 1468-1476.
22. Shahid NS, Steinhoff MC, Hoque SS, Begum T, Thompson C, et al. (1995) Serum, breast milk, and infant antibody after maternal immunisation with pneumococcal vaccine. Lancet 346: 1252-1257.
23. Lehmann D, Pomat WS, Riley ID, Alpers MP, (2003) Studies of maternal immunisation with pneumococcal polysaccharide vaccine in Papua New Guinea. Vaccine 21: 3446-3450.
24. Obaro SK, Deubzer HE, Newman VO, Adegbola RA, Greenwood BM, et al. (2004) Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcal polysaccharide vaccine during pregnancy. Pediatr Infect Dis J 23: 1023-1029.
25. Munoz FM, Englund JA, Cheesman CC, Maccato ML, Pinell PM, et al. (2001) Maternal immunization with pneumococcal polysaccharide vaccine in the third trimester of gestation. Vaccine 20: 826-837.
26. Dagan R, Givon-Lavi N, Zamir O, Sikuler-Cohen M, Guy L, et al. (2002) Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. Journal of Infectious Diseases 185: 927-936.
27. Eskola J, Kilpi T, Palmu A, Jokinen J, Haapakoski J, et al. (2001) Efficacy of a pneumococcal conjugate vaccine against acute otitis media. The New England journal of medicine 344: 403.
28. Mbelle N, Huebner RE, Wasas AD, Kimura A, Chang I, et al. (1999) Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine. The Journal of Infectious Diseases 180: 1171-1176.
29. Millar EV, O'Brien KL, Watt JP, Bronsdon MA, Dallas J, et al. (2006) Effect of community-wide conjugate pneumococcal vaccine use in infancy on nasopharyngeal carriage through 3 years of age: a cross-sectional study in a high-risk population. Clin Infect Dis 43: 8-15.
30. Dunais B, Bruno P, Carsenti-Dellamonica H, Touboul P, Dellamonica P, et al. (2008) Trends in nasopharyngeal carriage of Streptococcus pneumoniae among children attending daycare centers in southeastern France from 1999 to 2006. Pediatr Infect Dis J 27: 1033-1035.
31. Frazao N, Brito-Avo A, Simas C, Saldanha J, Mato R, et al. (2005) Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon. Pediatric Infectious Disease Journal 24: 243-252.
32. Ghaffar F, Barton T, Lozano J, Muniz LS, Hicks P, et al. (2004) Effect of the 7 valent pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae in the first 2 years of life. Clinical Infectious Diseases 39: 930-938.
33. Huang SS, Platt R, Rifas-Shiman SL, Pelton SI, Goldmann D, et al. (2005) Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004. Pediatrics 116: e408-413.
34. Muñoz Almagro C, Jordan I, Gene A, Latorre C, Garcia Garcia JJ, et al. (2008) Emergence of invasive pneumococcal disease caused by nonvaccine serotypes in the era of 7 valent conjugate vaccine. Clinical Infectious Diseases 46: 174-182.
35. Huang SS, Hinrichsen VL, Stevenson AE, Rifas-Shiman SL, Kleinman K, et al. (2009) Continued impact of pneumococcal conjugate vaccine on carriage in young children. Pediatrics 124: e1-11.
36. Pelton SI, Huot H, Finkelstein JA, Bishop CJ, Hsu KK, et al. (2007) Emergence of 19A as virulent and multidrug resistant pneumococcus in Massachusetts following universal immunization of infants with pneumococcal conjugate vaccine. The Pediatric Infectious Disease Journal 26: 468.