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Volumn 345, Issue 7884, 2012, Pages

Administer tranexamic acid early to injured patients at risk of substantial bleeding

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

EID: 84869771520     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.e7133     Document Type: Article
Times cited : (9)

References (14)
  • 1
    • 33745155396 scopus 로고    scopus 로고
    • Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations
    • Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma 2006;60:S3-11.
    • (2006) J Trauma , vol.60
    • Kauvar, D.S.1    Lefering, R.2    Wade, C.E.3
  • 3
    • 77956201218 scopus 로고    scopus 로고
    • Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    • Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg 2010;252:434-42.
    • (2010) Ann Surg , vol.252 , pp. 434-442
    • Kashuk, J.L.1    Moore, E.E.2    Sawyer, M.3    Wohlauer, M.4    Pezold, M.5    Barnett, C.6
  • 4
    • 84861503406 scopus 로고    scopus 로고
    • Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis
    • Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054.
    • (2012) BMJ , vol.344
    • Ker, K.1    Edwards, P.2    Perel, P.3    Shakur, H.4    Roberts, I.5
  • 5
    • 79952269248 scopus 로고    scopus 로고
    • Antifibrinolytic drugs for acute traumatic injury
    • on behalf of the CRASH-2 trial collaborators
    • Roberts I, Shakur H, Ker K, Coats T, on behalf of the CRASH-2 trial collaborators. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev 2011;1:CD004896.
    • (2011) Cochrane Database Syst Rev , vol.1
    • Roberts, I.1    Shakur, H.2    Ker, K.3    Coats, T.4
  • 6
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32.
    • (2010) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, I.2    Bautista, R.3    Caballero, J.4    Coats, T.5    Dewan, Y.6
  • 7
    • 84867279403 scopus 로고    scopus 로고
    • Effect of tranexamic acid on mortality in patients with traumatic bleeding: Prespecified analysis of data from randomised controlled trial
    • Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, et al. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ 2012:345:e5839.
    • (2012) BMJ , vol.345
    • Roberts, I.1    Perel, P.2    Prieto-Merino, D.3    Shakur, H.4    Coats, T.5    Hunt, B.J.6
  • 8
    • 79953163189 scopus 로고    scopus 로고
    • The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial
    • Mar 26
    • Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011 Mar 26;377:1096-101.
    • (2011) Lancet , vol.377 , pp. 1096-1101
    • Roberts, I.1    Shakur, H.2    Afolabi, A.3    Brohi, K.4    Coats, T.5    Dewan, Y.6
  • 9
    • 84857508828 scopus 로고    scopus 로고
    • Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    • Ker K, Kiriya J, Perel P, Edwards P, Shakur H, Roberts I. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med 2012;12:3.
    • (2012) BMC Emerg Med , vol.12 , pp. 3
    • Ker, K.1    Kiriya, J.2    Perel, P.3    Edwards, P.4    Shakur, H.5    Roberts, I.6
  • 10
    • 79955763845 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial
    • Guerriero C, Cairns J, Perel P, Shakur H, Roberts I. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS One 2011;6:e18987.
    • (2011) PLoS One , vol.6
    • Guerriero, C.1    Cairns, J.2    Perel, P.3    Shakur, H.4    Roberts, I.5
  • 11
    • 84857430357 scopus 로고    scopus 로고
    • Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study
    • Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012;147:113-9.
    • (2012) Arch Surg , vol.147 , pp. 113-119
    • Morrison, J.J.1    Dubose, J.J.2    Rasmussen, T.E.3    Midwinter, M.J.4
  • 12
    • 22144431885 scopus 로고    scopus 로고
    • Contradicted and initially stronger effects in highly cited clinical research
    • DOI 10.1001/jama.294.2.218
    • Ioannidis JPA. Contradicted and initially stronger effects in highly cited clinical research. JAMA 2005;294:218-28. (Pubitemid 41043792)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.2 , pp. 218-228
    • Ioannidis, J.P.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.