Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Lee, P H ^a,b,c   Perlis, R H ^a,b,c   Jung, J Y ^d   Byrne, E M ^e,f   Rueckert, E ^a,b,c   Siburian, R ^a   Haddad, S ^a   Mayerfeld, C E ^a   Heath, A C ^g   Pergadia, M L ^g   Madden, P A F ^g   Boomsma, D I ^h   Penninx, B W ⁱ   Sklar, P ^j   Martin, N G ^e   Wray, N R ^f   Purcell, S M ^a,b,c,j   Smoller, J W ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d Harvard Medical School Center for Biomedical Informatics   (United States)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h VU UNIVERSITY AMSTERDAM   (Netherlands)

ⁱ VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^j MOUNT SINAI SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Genome wide association study; glutamatergic synaptic neurotransmission; major depressive disorder; pathway analysis

Indexed keywords

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUTAMATERGIC SYNAPTIC TRANSMISSION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MOLECULAR GENETICS; MULTI LOCUS GENOME WIDE ASSOCIATION ANALYSIS; NERVE CELL PLASTICITY; SYNAPTIC TRANSMISSION; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; METABOLISM; PHYSIOLOGY;

GLUTAMIC ACID;

DEPRESSIVE DISORDER, MAJOR; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GLUTAMIC ACID; HUMANS; SYNAPTIC TRANSMISSION;

EID: 84869753622     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.95     Document Type: Article

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