-
1
-
-
78649939570
-
Synthesis of purine derivatives as scaffolds for a diversity of biological activities
-
doi:10.2174/138527210793358240
-
Conejo-Garcia A, Cruz-Lopez O, Gomez-Perez V, Morales F, Garcia-Rubino ME, Kimatrai M, Nunez MC, M. Campos J (2010) Synthesis of purine derivatives as scaffolds for a diversity of biological activities. Curr Org Chem 14:2463-2482. doi:10.2174/138527210793358240
-
(2010)
Curr Org Chem
, vol.14
, pp. 2463-2482
-
-
Conejo-Garcia, A.1
Cruz-Lopez, O.2
Gomez-Perez, V.3
Morales, F.4
Garcia-Rubino, M.E.5
Kimatrai, M.6
Nunez, M.C.7
Campos, J.M.8
-
2
-
-
79961039537
-
The benefits of constructing leads from fragment hits
-
doi:10.4155/fmc.11.46
-
FoloppeN (2011) The benefits of constructing leads from fragment hits. Future Med Chem 3:1111-1115. doi:10.4155/fmc.11.46
-
(2011)
Future Med Chem
, vol.3
, pp. 1111-1115
-
-
Foloppe, N.1
-
3
-
-
34247884237
-
An efficient synthesis of substituted cytosines and purines under focused microwave irradiation
-
DOI 10.1016/j.tet.2007.02.124, PII S0040402007003389
-
Huang L, Cherng Y-C, Cheng Y-R, Jang J-P, Chao Y-L, Cherng Y-J (2007) An efficient synthesis of substituted cytosines and purines under focused microwave irradiation. Tetrahedron 63:5323-5327. doi:10.1016/j.tet.2007.02.124 (Pubitemid 46702213)
-
(2007)
Tetrahedron
, vol.63
, Issue.24
, pp. 5323-5327
-
-
Huang, L.-K.1
Cherng, Y.-C.2
Cheng, Y.-R.3
Jang, J.-P.4
Chao, Y.-L.5
Cherng, Y.-J.6
-
4
-
-
48149098365
-
Recent advances in the synthesis of purine derivatives and their precursors
-
doi:10.1016/j.tet.2008.05.115
-
Legraverend M (2008) Recent advances in the synthesis of purine derivatives and their precursors. Tetrahedron 64:8585-8603. doi:10.1016/j.tet. 2008.05.115
-
(2008)
Tetrahedron
, vol.64
, pp. 8585-8603
-
-
Legraverend, M.1
-
5
-
-
0346100650
-
Antimycobacterial Agents. 1. Thio Analogues of Purine
-
DOI 10.1021/jm030389b
-
Pathak AK, Pathak V, Seitz LE, Suling WJ, Reynolds RC (2004) Antimycobacterial agents. 1. Thio analogues of Purine. J Med Chem 47:273-276. doi:10.1021/jm030389b (Pubitemid 38040510)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.1
, pp. 273-276
-
-
Pathak, A.K.1
Pathak, V.2
Seitz, L.E.3
Suling, W.J.4
Reynolds, R.C.5
-
6
-
-
13444272999
-
Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors
-
DOI 10.1021/jm0408767
-
Laufer SA, Dormeyer DM, Scior TR, Albrecht W, Hauser DRJ (2005) Synthesis and biological testing of purine derivates as potential ATP-competive kinase inhibitors. J Med Chem 48:710- 722. doi:10.1021/jm0408767 (Pubitemid 40209093)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.3
, pp. 710-722
-
-
Laufer, S.A.1
Domeyer, D.M.2
Scior, T.R.F.3
Albrecht, W.4
Hauser, D.R.J.5
-
7
-
-
33646093239
-
Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: Comparisons with the National Cancer Institute data
-
doi:10.1097/01.cad.0000190280.60005.05
-
Bracht K, Boubakari F, Grünert R, Bednarski PJ (2006) Correlations between the activities of 19 anti-tumor agents and the intracellular glutathione concentrations in a panel of 14 human cancer cell lines: comparisons with the National Cancer Institute data. Anticancer Drugs 17:41-51. doi:10.1097/01.cad. 0000190280.60005.05
-
(2006)
Anticancer Drugs
, vol.17
, pp. 41-51
-
-
Bracht, K.1
Boubakari, F.2
Grünert, R.3
Bednarski, P.J.4
-
8
-
-
77950022453
-
Non-additivity of functional group contributions in protein- ligand binding: A comprehensive study by crystallography and isothermal titration calorimetry
-
doi:10.1016/j.jmb.2010.02.007
-
Baum B, Muley L, Smolinski M, Heine A, Hangauer D, Klebe G (2010) Non-additivity of functional group contributions in protein- ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry. J Mol Biol 397:1042-1054. doi:10.1016/j.jmb.2010.02.007
-
(2010)
J Mol Biol
, vol.397
, pp. 1042-1054
-
-
Baum, B.1
Muley, L.2
Smolinski, M.3
Heine, A.4
Hangauer, D.5
Klebe, G.6
-
9
-
-
52049123291
-
Do enthalpy and entropy distinguish first in class from best in class?
-
doi:10.1016/j.drudis.2008.07.005
-
Freire E (2008) Do enthalpy and entropy distinguish first in class from best in class?. Drug Discov Today 13:869-874. doi:10.1016/j.drudis.2008.07.005
-
(2008)
Drug Discov Today
, vol.13
, pp. 869-874
-
-
Freire, E.1
-
10
-
-
70349731747
-
A thermodynamic approach to the affinity optimization of drug candidates
-
doi:10.1111/j.1747-0285.2009.00880
-
Freire E (2009) A thermodynamic approach to the affinity optimization of drug candidates. Chem Biol Drug Des 74:468-472. doi:10.1111/j.1747-0285.2009. 00880
-
(2009)
Chem Biol Drug des
, vol.74
, pp. 468-472
-
-
Freire, E.1
-
11
-
-
77957237209
-
Enthalpic efficiency of ligand binding
-
doi:10.1021/ci100125a
-
Ferenczy GG, Keseru GM (2010) Enthalpic efficiency of ligand binding. J Chem Inf Model 50:1536-1541. doi:10.1021/ci100125a
-
(2010)
J Chem Inf Model
, vol.50
, pp. 1536-1541
-
-
Ferenczy, G.G.1
Keseru, G.M.2
-
12
-
-
79959243001
-
Thermodynamics of Ligand binding and efficiency
-
doi:10.1021/ml200010k
-
Reynolds CH, Holloway MK (2011) Thermodynamics of Ligand binding and efficiency. ACS Med Chem Lett 2:433-437. doi:10.1021/ml200010k
-
(2011)
ACS Med Chem Lett
, vol.2
, pp. 433-437
-
-
Reynolds, C.H.1
Holloway, M.K.2
-
13
-
-
34247574138
-
Synthesis, biological testing, and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitors
-
DOI 10.1021/jm061061w
-
Hauser DRJ, Scior TR, Dormeyer DM, Kammerer B, Laufer SA (2007) Synthesis, biological testing and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitor. J Med Chem 50:2060-2066. doi:10.1021/jm061061w (Pubitemid 46683059)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.9
, pp. 2060-2066
-
-
Hauser, D.R.J.1
Scior, T.2
Domeyer, D.M.3
Kammerer, B.4
Laufer, S.A.5
-
14
-
-
62949176376
-
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands
-
doi:10.1016/j.bmc.2009.02.030
-
Lambertucci C, Antonini I, Buccioni M, Dal Ben D, Kachare DD, Volpini R, Klotz KN, Cristalli G (2009) 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem 17:2812-2822. doi:10.1016/j.bmc.2009.02.030
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2812-2822
-
-
Lambertucci, C.1
Antonini, I.2
Buccioni, M.3
Dal Ben, D.4
Kachare, D.D.5
Volpini, R.6
Klotz, K.N.7
Cristalli, G.8
-
15
-
-
0000787520
-
Synthesis of potential anticancer agents. IX. 9-Ethyl-6-substituted- purines
-
doi:10.1021/ja01576a046
-
Montgomery JA, Temple C Jr (1957) Synthesis of potential anticancer agents. IX. 9-Ethyl-6-substituted-purines. J Am Chem Soc 79:5238-5242. doi:10.1021/ja01576a046
-
(1957)
J Am Chem Soc
, vol.79
, pp. 5238-5242
-
-
Montgomery, J.A.1
Temple Jr., C.2
|