The interaction of rs738409, obesity, and alcohol: A population-based autopsy study

American Journal of Gastroenterology

Volumn 107, Issue 11, 2012, Pages 1668-1674

  Dunn, Winston ^a   Zeng, Zhen ^a,b   O'Neil, Maura ^a   Zhao, Jie ^a   Whitener, Melissa ^a   Wan, Yu Jui ^a   Mitchell, Erik K ^c   Handler, Michael ^d   Weinman, Steven A ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b Beijing 302th Hospital   (China)

^c Frontier Forensics   (United States)

^d Neuropathology/Forensic Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL LIVER DISEASE; ALCOHOLISM; ARTICLE; AUTOPSY; BODY MASS; CORRELATIONAL STUDY; FATTY LIVER; FEMALE; GENOTYPE; HUMAN; HUMAN TISSUE; LIVER FIBROSIS; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ACCIDENTS, TRAFFIC; ADULT; AUTOPSY; FATTY LIVER; FATTY LIVER, ALCOHOLIC; FEMALE; GENOTYPE; HUMANS; KANSAS; LIPASE; LIVER CIRRHOSIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MISSOURI; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE;

EID: 84869505814     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2012.285     Document Type: Article

References (31)

1. Centers for Disease Control and Prevention (CDC). Behavioral Risk Factor Surveillance System Survey Data. GUSDoHaHS, Centers for Disease Control and Prevention: Atlanta, GA, 2008.
2. Flegal KM, Carroll MD, Ogden CL et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235-41.
3. Bellentani S, Saccoccio G, Masutti F et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000; 132: 112-7. (Pubitemid 30044177)
4. Ruhl CE, Everhart JE. Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population. Clin Gastroenterol Hepatol 2005; 3: 1260-8. (Pubitemid 41797679)
5. Yamada T, Fukatsu M, Suzuki S et al. Alcohol drinking may not be a major risk factor for fatty liver in Japanese undergoing a health checkup. Dig Dis Sci 2010; 55: 176-82.
6. Zhou YJ, Li YY, Nie YQ et al. Prevalence of fatty liver disease and its risk factors in the population of South China. World J Gastroenterol 2007; 13: 6419-24.
7. Lu XL, Luo JY, Tao M et al. Risk factors for alcoholic liver disease in China. World J Gastroenterol 2004; 10: 2423-6. (Pubitemid 39157774)
8. Szczepaniak LS, Nurenberg P, Leonard D et al. Magnetic resonance spectro scopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: E462-8. (Pubitemid 40110657)
9. Alatalo PI, Koivisto HM, Hietala JP et al. Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index. Am J Clin Nutr 2008; 88: 1097-103.
10. Liu B, Balkwill A, Reeves G et al. Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study. BMJ 2010; 340: c912.
11. Hart CL, Morrison DS, Batty GD et al. Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies. BMJ 2010; 340: c1240.
12. Wechsler H, Austin SB. Binge drinking: the five/four measure. J Stud Alcohol 1998; 59: 122-4.
13. Flowers NT, Naimi TS, Brewer RD et al. Patterns of alcohol consumption and alcohol-impaired driving in the United States. Alcohol Clin Exp Res 2008; 32: 639-44. (Pubitemid 351430431)
14. Schwimmer JB, Deutsch R, Kahen T et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118: 1388-93. (Pubitemid 46393782)
15. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21. (Pubitemid 40770284)
16. Brunt EM. Pathology of fatty liver disease. Mod Pathol 2007; 20 (Suppl 1): S40-8. (Pubitemid 46733652)
17. Trepo E, Gustot T, Degre D et al. Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. J Hepatol 2011; 55: 906-12.
18. Anderson RN, Rosenberg HM. Age standardization of death rates: implementation of the year 2000 standard. Natl Vital Stat Rep 1998; 47: 1-16, 20.
19. Naveau S, Giraud V, Borotto E et al. Excess weight risk factor for alcoholic liver disease. Hepatology 1997; 25: 108-11. (Pubitemid 27014994)
20. Lelbach W. Epidemiology of alcoholic liver disease. In: Popper HSF (eds). Progress in Liver Disease Vol 5. Grune and Stratton: New York, 1976, pp 494-515.
21. MacSween RN, Burt AD. Histologic spectrum of alcoholic liver disease. Semin Liver Dis 1986; 6: 221-32. (Pubitemid 17203551)
22. Ishak KG, Zimmerman HJ, Ray MB. Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res 1991; 15: 45-66.
23. Dunn W, Xu R, Schwimmer JB. Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease. Hepatology 2008; 47: 1947-54. (Pubitemid 351945562)
24. Dunn WBE, Sanyal AJ, McCullough et al. Modest alcohol consumption is associated with a decreased prevalence of steatohepatitis in patients with nonalcoholic fatty liver disease. Hepatology 2009; 50: 390A.
25. Cynthia A, Moylan AD, Pang H. Modest alcohol consumption attenuates expression of fibrosis-associated genes in patients with non-alcoholic fatty liver disease (NAFLD). Gastroenterology 2011; 140: S914-5.
26. Romeo S, Kozlitina J, Xing C et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-5.
27. Tian C, Stokowski RP, Kershenobich D et al. Variant in PNPLA3 is associated with alcoholic liver disease. Nat Genet 2010; 42: 21-3.
28. National Institute on Alcohol Abuse and Alcoholism. Helping Patients Who Drink Too Much: A Clinician's Guide. NIH Publication No. 05-3769. The Institute: Bethesda, MD 2005.
29. Amarapurkar A, Ghansar T. Fatty liver: experience from western India. Ann Hepatol 2007; 6: 37-40. (Pubitemid 46407487)
30. Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12: 1106-10.
31. Zois CD, Baltayiannis GH, Bekiari A et al. Steatosis and steatohepatitis in postmortem material from Northwestern Greece. World J Gastroenterol 2010; 16: 3944-9.