Maternal obesity alters feto-placental cytochrome P4501A1 activity

Placenta

Volumn 33, Issue 12, 2012, Pages 1045-1051

  Dubois, B N ^a   O'Tierney Ginn, P ^b   Pearson, J ^a   Friedman, J E ^c   Thornburg, K ^b   Cherala, G ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P4501A; Cytosol; Human placenta; Maternal obesity; Microsomes

Indexed keywords

CYTOCHROME P450 1A1; ETHOXYRESORUFIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; BODY WEIGHT; CELL FRACTIONATION; CENTRIFUGATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FEMALE; FETOPLACENTAL UNIT; FETUS; FETUS LIVER; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; LIPID DIET; LIVER; LIVER MICROSOME; MACACA; MATERNAL AGE; MATERNAL OBESITY; MATERNAL SMOKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BODY MASS INDEX; CYTOCHROME P-450 CYP1A1; CYTOSOL; DIET, HIGH-FAT; DOWN-REGULATION; FEMALE; HUMANS; LIVER; MACACA; MICROSOMES; MICROSOMES, LIVER; OBESITY; OXAZINES; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; RANDOM ALLOCATION; SOLUBILITY;

EID: 84869504722     PISSN: 01434004     EISSN: 15323102     Source Type: Journal    
DOI: 10.1016/j.placenta.2012.09.008     Document Type: Article

References (38)

1. Foley MR. Drug use during pregnancy. In: Porter RS, editor. The Merck manuals. Whitehouse Station, N.J., U.S.A.: Merck Sharp & Dohme Corp.
2. M.I. Blomberg, and B. Kallen Maternal obesity and morbid obesity: the risk for birth defects in the offspring Birth Defects Res A Clin Mol Teratol 88 2010 35 40
3. M.L. Watkins, S.A. Rasmussen, M.A. Honein, L.D. Botto, and C.A. Moore Maternal obesity and risk for birth defects Pediatrics 111 2003 1152 1158
4. K. Meyer, and Z. Lubo Fetal programming of cardiac function and disease Reprod Sci 14 2007 209 216
5. T.A. Slotkin Fetal nicotine or cocaine exposure: which one is worse? J Pharmacol Exp Ther 285 1998 931 945
6. M.R. Syme, J.W. Paxton, and J.A. Keelan Drug transfer and metabolism by the human placenta Clin Pharmacokinet 43 2004 487 514
7. K. Vahakangas, and P. Myllynen Drug transporters in the human blood-placental barrier Br J Pharmacol 158 2009 665 678
8. M. Pasanen The expression and regulation of drug metabolism in human placenta Adv Drug Deliv Rev 38 1999 81 97
9. J. Hakkola, M. Pasanen, J. Hukkanen, O. Pelkonen, J. Maenpaa, and R.J. Edwards Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta Biochem Pharmacol 51 1996 403 411
10. H. Bruchova, A. Vasikova, M. Merkerova, A. Milcova, J. Topinka, and I. Balascak Effect of maternal tobacco smoke exposure on the placental transcriptome Placenta 31 2009 186 191
11. M. Suter, A. Abramovici, L. Showalter, M. Hu, C.D. Shope, and M. Varner In utero tobacco exposure epigenetically modifies placental CYP1A1 expression Metabolism 59 2010 1481 1490
12. R.N. Hines, and D.G. McCarver The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes J Pharmacol Exp Ther 300 2002 355 360
13. P. Pavek, and Z. Dvorak Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues Curr Drug Metab 9 2008 129 143
14. R. Mojtabai Body mass index and serum folate in childbearing age women Eur J Epidemiol 19 2004 1029 1036
15. A. Vahratian Prevalence of overweight and obesity among women of childbearing age: results from the 2002 national survey of family growth Matern Child Health J 13 2009 268 273
16. A.E. Aitken, and E.T. Morgan Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes Drug Metab Dispos 35 2007 1687 1693
17. K.L. Audus Controlling drug delivery across the placenta Eur J Pharm Sci 8 1999 161 165
18. R.P. Meyer, R.L. Lindberg, F. Hoffmann, and U.A. Meyer Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency Biol Chem 386 2005 1157 1164
19. R.P. Meyer, M. Podvinec, and U.A. Meyer Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme Mol Pharmacol 62 2002 1061 1067
20. Y. Nakagawa, J. Fujimoto, and T. Tamaya Placental growth by the estrogen-dependent angiogenic factors, vascular endothelial growth factor and basic fibroblast growth factor, throughout gestation Gynecol Endocrinol 19 2004 259 266
21. L. Myatt Placental adaptive responses and fetal programming J Physiol 572 2006 25 30
22. E. Angiolini, A. Fowden, P. Coan, I. Sandovici, P. Smith, and W. Dean Regulation of placental efficiency for nutrient transport by imprinted genes Placenta 27 Suppl. A 2006 S98 102
23. A.L. Fowden, A.N. Sferruzzi-Perri, P.M. Coan, M. Constancia, and G.J. Burton Placental efficiency and adaptation: endocrine regulation J Physiol 587 2009 3459 3472
24. W.F. Grant, M.B. Gillingham, A.K. Batra, N.M. Fewkes, S.M. Comstock, and D. Takahashi Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates PLoS One 6 2011 e17261
25. A.H. Phillips, and R.G. Langdon Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies J Biol Chem 237 1962 2652 2660
26. J.L. Vermilion, and M.J. Coon Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states J Biol Chem 253 1978 2694 2704
27. J. Muntane-Relat, J.C. Ourlin, J. Domergue, and P. Maurel Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture Hepatology 22 1995 1143 1153
28. R. Aaltonen, T. Heikkinen, K. Hakala, K. Laine, and A. Alanen Transfer of proinflammatory cytokines across term placenta Obstet Gynecol 106 2005 802 807
29. P.M. Catalano, L. Presley, J. Minium, and S. Hauguel-de Mouzon Fetuses of obese mothers develop insulin resistance in utero Diabetes Care 32 2009 1076 1080
30. J.C. Challier, S. Basu, T. Bintein, J. Minium, K. Hotmire, and P.M. Catalano Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta Placenta 29 2008 274 281
31. S. Bo, G. Menato, A. Lezo, A. Signorile, C. Bardelli, and F. De Michieli Dietary fat and gestational hyperglycaemia Diabetologia 44 2001 972 978
32. C.E. McCurdy, J.M. Bishop, S.M. Williams, B.E. Grayson, M.S. Smith, and J.E. Friedman Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates J Clin Invest 119 2009 323 335
33. K. Iwasaki, and Y. Uno Cynomolgus monkey CYPs: a comparison with human CYPs Xenobiotica 39 2009 578 581
34. D.B. West, and B. York Dietary fat, genetic predisposition, and obesity: lessons from animal models Am J Clin Nutr 67 1998 505S 512S
35. G.M. Pacifici, and R. Nottoli Placental transfer of drugs administered to the mother Clin Pharmacokinet 28 1995 235 269
36. G. Cheymol, J.M. Poirier, J. Barre, A. Pradalier, and J. Dry Comparative pharmacokinetics of intravenous propranolol in obese and normal volunteers J Clin Pharmacol 27 1987 874 879
37. I.H. Benedek, R.A. Blouin, and P.J. McNamara Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects Br J Clin Pharmacol 18 1984 941 946
38. A. Tchernof, and J.P. Despres Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women Horm Metab Res 32 2000 526 536