Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status

Head and Neck

Volumn 34, Issue 12, 2012, Pages 1727-1733

  Spector, Matthew E ^a   Gallagher, K Kelly ^a   Light, Emily ^a   Ibrahim, Mohannad ^a   Chanowski, Eric J ^a   Moyer, Jeffrey S ^a   Prince, Mark E ^a   Wolf, Gregory T ^a   Bradford, Carol R ^a   Cordell, Kitrina ^a   McHugh, Jonathan B ^a   Carey, Thomas ^a   Worden, Francis P ^a   Eisbruch, Avraham ^a   Chepeha, Douglas B ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

biomarkers; lymph node metastasis; matted nodes; oropharyngeal squamous cell carcinoma; prognosis

Indexed keywords

BIOLOGICAL MARKER; CARBOPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PACLITAXEL;

ADULT; ARTICLE; CANCER PROGNOSIS; CHEMORADIOTHERAPY; DISEASE SPECIFIC SURVIVAL; DISTANT METASTASIS; FEMALE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OROPHARYNX CARCINOMA; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; WART VIRUS;

BROMHEXINE; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TISSUE ARRAY ANALYSIS;

EID: 84869502877     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21997     Document Type: Article

References (15)

1. Marur S, D'souza G, Westra WH, Forastiere AA,. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 2010; 11: 781-789.
2. Kumar B, Cordell KG, Lee JS, et al. EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol 2008; 26: 3128-3137.
3. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010; 363: 24-35.
4. Mendenhall WM, Logan HL,. Human papillomavirus and head and neck cancer. Am J Clin Oncol 2009 [Epub ahead of print].
5. Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J,. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009; 27: 1992-1998.
6. Taneja C, Allen H, Koness RJ, Radie-Keane K, Wanebo HJ,. Changing patterns of failure of head and neck cancer. Arch Otolaryngol Head Neck Surg 2002; 128: 324-327.
7. Daly ME, Le QT, Maxim PG, et al. Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 2010; 76: 1339-1346.
8. Feng FY, Kim HM, Lyden TH, et al. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 2007; 68: 1289-1298.
9. Feng FY, Kim HM, Lyden TH, et al. Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results. J Clin Oncol 2010; 28: 2732-2738.
10. Yang H, Yang K, Khafagi A, et al. Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies. Proc Natl Acad Sci U S A 2005; 102: 7683-7688.
11. Posner MR, Hershock DM, Blajman CR, et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007; 357: 1705-1715.
12. Klozar J, Kratochvil V, Salakova M, et al. HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur Arch Otorhinolaryngol 2008; 265 Suppl 1: S75-S82.
13. Carvalho P, Baldwin D, Carter R, Parsons C,. Accuracy of CT in detecting squamous carcinoma metastases in cervical lymph nodes. Clin Radiol 1991; 44: 79-81.
14. Weinstein G, O'Malley B, Cohen M, Quon H,. Transoral robotic surgery for advanced oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 2010; 136: 1079-1085.
15. Rich JT, Milov S, Lewis JS Jr, Thorstad WL, Adkins DR, Haughey BH,. Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors. Laryngoscope 2009; 119: 1709-1719.