Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: Clinical Outcomes and Patterns of Failure

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 5, 2010, Pages 1339-1346

  Daly, Megan E ^a   Le, Quynh Thu ^a   Maxim, Peter G ^a   Loo Jr , Billy W ^a   Kaplan, Michael J ^a   Fischbein, Nancy J ^a   Pinto, Harlan ^a   Chang, Daniel T ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

IMRT; Intensity modulated; Oropharynx; radiotherapy; Squamous cell carcinoma

Indexed keywords

ACUTE TOXICITY; CETUXIMAB; CLINICAL OUTCOME; CLINICAL TARGET VOLUMES; CURATIVE INTENT; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FAILURE PATTERNS; IMRT; INTENSITY-MODULATED RADIOTHERAPY; LOCAL FAILURE; OROPHARYNGEAL; OROPHARYNGEAL CANCER; OROPHARYNX; OVERALL SURVIVAL; PATTERNS OF FAILURE; PERSISTENT DISEASE; PLATINUM-BASED CHEMOTHERAPY; REGIONAL FAILURES; SKIN REACTION; SQUAMOUS CELL CARCINOMA; STANFORD UNIVERSITY;

CHEMOTHERAPY; DISEASE CONTROL; PATHOLOGY; PATIENT MONITORING; PLATINUM; RADIOTHERAPY; TOXICITY;

PHYSICAL THERAPY;

CARBOPLATIN; CETUXIMAB; CISPLATIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; ORAL MUCOSAL DISEASE; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; SKIN TOXICITY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME; TUMOR VOLUME;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; CISPLATIN; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OROPHARYNGEAL NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY, INTENSITY-MODULATED; SURVIVAL RATE; TREATMENT FAILURE;

EID: 77949549054     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.04.006     Document Type: Article

References (41)

1. Parsons J.T.M.W., Stringer S.P., Amdur R.J., Hinerman R.W., Villaret D.B., Moore-Higgs G.J., Greene B.D., Speer T.W., Cassisi N.J., and Million R.R. Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 94 (2002) 2967-2980
2. Adelstein D.J., Li Y., Adams G.L., et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21 (2003) 92-98
3. Brizel D.M., Albers M.E., Fisher S.R., et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 338 (1998) 1798-1804
4. Denis F., Garaud P., Bardet E., et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 22 (2004) 69-76
5. Calais G., Alfonsi M., Bardet E., et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91 (1999) 2081-2086
6. Maguire P.D., Meyerson M.B., Neal C.R., et al. Toxic cure: Hyperfractionated radiotherapy with concurrent cisplatin and fluorouracil for Stage III and IVA head-and-neck cancer in the community. Int J Radiat Oncol Biol Phys 58 (2004) 698-704
7. Chau R.M., Teo P.M., Kam M.K., et al. Dosimetric comparison between 2-dimensional radiation therapy and intensity modulated radiation therapy in treatment of advanced T-stage nasopharyngeal carcinoma: to treat less or more in the planning organ-at-risk volume of the brainstem and spinal cord. Med Dosim 32 (2007) 263-270
8. Saibishkumar E.P., Jha N., Scrimger R.A., et al. Sparing the parotid glands and surgically transferred submandibular gland with helical tomotherapy in post-operative radiation of head and neck cancer: a planning study. Radiother Oncol 85 (2007) 98-104
9. Bhide S., Clark C., Harrington K., et al. Intensity modulated radiotherapy improves target coverage and parotid gland sparing when delivering total mucosal irradiation in patients with squamous cell carcinoma of head and neck of unknown primary site. Med Dosim 32 (2007) 188-195
10. Kristensen C.A., Kjaer-Kristoffersen F., Sapru W., et al. Nasopharyngeal carcinoma. Treatment planning with IMRT and 3D conformal radiotherapy. Acta Oncol 46 (2007) 214-220
11. Cozzi L., Fogliata A., Bolsi A., et al. Three-dimensional conformal vs. intensity-modulated radiotherapy in head-and-neck cancer patients: Comparative analysis of dosimetric and technical parameters. Int J Radiat Oncol Biol Phys 58 (2004) 617-624
12. Eisbruch A., Ship J.A., Dawson L.A., et al. Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer. World J Surg 27 (2003) 832-837
13. Pacholke H.D., Amdur R.J., Morris C.G., et al. Late xerostomia after intensity-modulated radiation therapy versus conventional radiotherapy. Am J Clin Oncol 28 (2005) 351-358
14. Jabbari S., Kim H.M., Feng M., et al. Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: Initial report. Int J Radiat Oncol Biol Phys 63 (2005) 725-731
15. Malouf J.G., Aragon C., Henson B.S., et al. Influence of parotid-sparing radiotherapy on xerostomia in head and neck cancer patients. Cancer Detect Prev 27 (2003) 305-310
16. Eisbruch A., Kim H.M., Terrell J.E., et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 50 (2001) 695-704
17. Kam M.K., Leung S.F., Zee B., et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 25 (2007) 4873-4879
18. Daly M.E., Lieskovsky Y., Pawlicki T., et al. Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma. Head Neck 29 (2007) 211-220
19. Eisbruch A., Levendag P.C., Feng F.Y., et al. Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences. Int J Radiat Oncol Biol Phys 69 (2007) S40-S42
20. Chao K.S., Ozyigit G., Blanco A.I., et al. Intensity-modulated radiation therapy for oropharyngeal carcinoma: Impact of tumor volume. Int J Radiat Oncol Biol Phys 59 (2004) 43-50
21. Schoenfeld G.O., Amdur R.J., Morris C.G., et al. Patterns of failure and toxicity after intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 71 (2008) 377-385
22. de Arruda F.F., Puri D.R., Zhung J., et al. Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: The Memorial Sloan-Kettering Cancer Center experience. Int J Radiat Oncol Biol Phys 64 (2006) 363-373
23. Lawson J.D., Otto K., Chen A., et al. Concurrent platinum-based chemotherapy and simultaneous modulated accelerated radiation therapy for locally advanced squamous cell carcinoma of the tongue base. Head Neck 30 (2008) 327-335
24. Huang K., Xia P., Chuang C., et al. Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: The University of California-San Francisco experience. Cancer 113 (2008) 497-507
25. Sanguineti G., Gunn G.B., Endres E.J., et al. Patterns of locoregional failure after exclusive IMRT for oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 72 (2008) 737-746
26. Eisbruch A., Marsh L.H., Dawson L.A., et al. Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys 59 (2004) 28-42
27. Green F., Page D., and Fleming I. AJCC manual for staging of cancer. 6th edition (2002), Lippincott, Philadelphia, PA
28. Gregoire V., Eisbruch A., Hamoir M., et al. Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck. Radiother Oncol 79 (2006) 15-20
29. Gregoire V., Levendag P., Ang K.K., et al. CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines. Radiother Oncol 69 (2003) 227-236
30. Madu C.N., Quint D.J., Normolle D.P., et al. Definition of the supraclavicular and infraclavicular nodes: Implications for three-dimensional CT-based conformal radiation therapy. Radiology 221 (2001) 333-339
31. Sohn J.W., Suh J.H., and Pohar S. A method for delivering accurate and uniform radiation dosages to the head and neck with asymmetric collimators and a single isocenter. Int J Radiat Oncol Biol Phys 32 (1995) 809-813
32. Chao K.S., Ozyigit G., Tran B.N., et al. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 55 (2003) 312-321
33. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346
34. Kaplan E., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
35. Emami B., Lyman J., Brown A., et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21 (1991) 109-122
36. Rusthoven K.E., Raben D., Ballonoff A., et al. Effect of radiation techniques in treatment of oropharynx cancer. Laryngoscope 118 (2008) 635-639
37. Hodge C.W., Bentzen S.M., Wong G., et al. Are we influencing outcome in oropharynx cancer with intensity-modulated radiotherapy? An inter-era comparison. Int J Radiat Oncol Biol Phys 69 (2007) 1032-1041
38. Lee N.Y., de Arruda F.F., Puri D.R., et al. A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 66 (2006) 966-974
39. Thorstad W.L., Hong S., and Hope A.J. Patterns of failure in patients receiving intensity modulated radiation therapy (IMRT) for head and neck cancer (2005), American Society for Therapeutic Radiology and Oncology, Denver, CO
40. Amdur R.J., Li J.G., Liu C., et al. Unnecessary laryngeal irradiation in the IMRT era. Head Neck 26 (2004) 257-263
41. Chang D.T., Sandow P.R., Morris C.G., et al. Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?. Head Neck 29 (2007) 528-536