The new nitric oxide donor 2-nitrate-1,3-dibuthoxypropan alters autonomic function in spontaneously hypertensive rats

Autonomic Neuroscience: Basic and Clinical

Volumn 171, Issue 1-2, 2012, Pages 28-35

  França Silva, Maria S ^a   Monteiro, Matheus M O ^a   Queiroz, Thyago M ^a   Santos, Alexsandro F ^a   Athayde Filho, Petrônio F ^a   Braga, Valdir A ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Autonomic function; Bradycardia; Hypertension; Nitric oxide

Indexed keywords

2 NITRATE 1,3 DIBUTHOXYPROPAN; ATROPINE; HEXAMETHONIUM; METHYLENE BLUE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BRADYCARDIA; CARDIOVASCULAR EFFECT; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; GANGLION BLOCK; HEART RATE; HYPERTENSION; HYPOTENSION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC TONE; TACHYCARDIA; VAGOTOMY; VAGUS NERVE STIMULATION; WISTAR KYOTO RAT;

ANALYSIS OF VARIANCE; ANIMALS; ATROPINE; BLOOD PRESSURE; ENZYME INHIBITORS; HEART RATE; MALE; METHYLENE BLUE; NITRATES; NITRIC OXIDE DONORS; PARASYMPATHOLYTICS; PROPANE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VAGOTOMY; WAKEFULNESS;

EID: 84869500110     PISSN: 15660702     EISSN: 18727484     Source Type: Journal    
DOI: 10.1016/j.autneu.2012.10.002     Document Type: Article

References (25)

1. Archer S.L., Huang J.M., Hamp l V., Nelson D.P., Shultz P.J., Weir K. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:7583-7587.
2. Braga V.A. Dietary salt enhances angiotensin-II-induced superoxide formation in the rostral ventrolateral medulla. Auton. Neurosci. Basic Clin. 2010, 155:14-18.
3. Caputi A.P., Rossi F., Carney K., Brezenoff H.E. Modulatory effect of brain acetylcholine on reflex-induced bradycardia and tachycardia in conscious rats. JPET 1980, 215:309-316.
4. Crestani, S. Efeitos das frações semi-purificadas da Maytenus ilicifolia Mart. ex Reissek (Celastraceae) sobre a pressão arterial de ratos. 111 p. 2008. Dissertação (Mestrado) - Universidade Federal do Paraná, Curitiba.
5. Fazan R., Silva V.J.D., Salgado H.C. Modelos de hipertensão arterial. Rev. Bras. Hipertens 2001, 8:19-29.
6. Feelisch M., Noack E. Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. Eur. J. Pharmacol. 1987, 142:465-469.
7. Fletcher J., Moody W.E., Chowdhary S., Coote J.H. NO-cGMP pathway at ventrolateral medullary cardiac inhibitory sites enhances the baroreceptor reflex bradycardia in the rat. Brain Res. 2006, 1123:125-134.
8. Franca-Silva M.S., Luciano M.N., Ribeiro T.P., Silva J.S., Santos A.F., Franca K.C., Nakao L.S., Athayde-Filho P.F., Braga V.A., Medeiros I.A. The 2-nitrate-1,3-dibuthoxypropan, a new nitric oxide donor, induces vasorelaxation in mesenteric arteries of the rat. Eur. J. Pharmacol. 2012, 690:170-175.
9. Herring N., Paterson D.J. Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. J. Physiol. 2001, 535:507-518.
10. Kishi T., Hirooka Y., Sakai K., Shigematsu H., Shimokawa H., Takeshita A. Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release. Hypertension 2001, 38:896-901.
11. Marín J., Rodrigues-Martinez A. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol. Ther. 1997, 75:111-134.
12. McDonald L.J., Murad F. Nitric oxide and cyclic GMP signaling. Proc. Soc. Exp. Biol. Med. 1996, 211:1-6.
13. + in spontaneously hypertensive rats. Nitric Oxide 2012, 26:11-117.
14. Needleman P. Organic nitrate metabolism. Annu. Rev. Pharmacol. Toxicol. 1976, 16:81-93.
15. Paulo M., Rodrigues J.D., Silva R.S., Bendhack L.M. A new NO donor failed to release NO and to induce relaxation in the rat basilar artery. Eur. J. Pharm. Sci. 2012, 45:344-350.
16. Pinto Y.M., Paul M., Ganten D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovasc. Res. 1998, 39:77-88.
17. Portaluppi F., Boari B., Manfredini R. Oxidative stress in essential hypertension. Curr. Pharm. Des. 2004, 10:1695-1698.
18. Rajapakse N.W., Mattson D.L. Role of l-arginine in nitric oxide production in health and hypertension. Clin. Exp. Pharmacol. Physiol. 2009, 36:249-255.
19. Santos, A.F., 2009. Novas Perspectivas da Glicerina - Síntese de Novos Nitratos com Propriedades Farmacológicas e Melhoradores de Cetano. 116 p. Dissertação (Mestrado) - Universidade Federal da Paraíba, João Pessoa.
20. Schmitt C.A., Dirsch V.M. Modulation of endothelial nitric oxide by plant-derived products. Nitric Oxide-Biol. Ch. 2009, 21:77-91.
21. Smith P.A., Grahan L.N., Mackintosh A.F., Stoker J.B., Mary D.A.S.G. Relationship between central sympathetic activity and stages of human hypertension. Am. J. Hypertens. 2004, 17:217-222.
22. Wang Y.X., Cheng X., Pang C.C.Y. Vascular pharmacology of methylene blue in vitro and in vivo: a comparison with NG-nitro-l-arginine and diphenyleneiodonium. Br. J. Pharmacol. 1995, 114:194-202.
23. Wei E.P., Moskowitz M.A., Boccalini P., Kontos H.A. Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles. Circ. Res. 1992, 70:1313-1319.
24. Wymann M.P., Zvelebil M., Laffargue M. Phosphoinositide 3-kinase signaling-which way to target?. Trends Pharmacol. Sci. 2003, 24:366-376.
25. Zanzinger J. Role of nitric oxide in the neural control of cardiovascular functions. Cardiovasc. Res. 1999, 43:639-649.