Multiplexed tracking of protease activity using a single color of quantum dot vector and a time-gated Förster resonance energy transfer relay

Analytical Chemistry

Volumn 84, Issue 22, 2012, Pages 10136-10146

  Algar, W Russ ^a,c,f   Malanoski, Anthony P ^a   Susumu, Kimihiro ^b,e   Stewart, Michael H ^b   Hildebrandt, Niko ^d   Medintz, Igor L ^a  

^a Center for Bio/Molecular Science and Engineering   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c GEORGE MASON UNIVERSITY   (United States)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e SOTERA DEFENSE SOLUTIONS   (United States)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL RESEARCH; BIOSENSING; DRUG DISCOVERY; ENZYME SPECIFICITY; FLUORESCENT DYES; INHIBITION CONSTANTS; KINETIC ASSAY; MULTI-FUNCTIONAL NANOPARTICLES; MULTIPLEXED DETECTION; NANOSCALE SIZE; OPTICAL SENSING; PHOTOPHYSICAL; PROSPECTIVE APPLICATIONS; PROTEASE ACTIVITIES; PROTEOLYTIC ACTIVATION; RATIOMETRIC ANALYSIS; RESONANCE ENERGY TRANSFER; SINGLE NANOPARTICLE; TERBIUM COMPLEX;

BIOSENSORS; COLOR; ENERGY TRANSFER; PORTALS; REACTION RATES; RESEARCH; SEMICONDUCTOR QUANTUM DOTS; TERBIUM;

MULTIPLEXING;

CHYMOTRYPSIN; PEPTIDE; QUANTUM DOT; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; COLOR; ENZYME ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; TIME;

AMINO ACID SEQUENCE; CHYMOTRYPSIN; COLOR; ENZYME ASSAYS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR SEQUENCE DATA; PEPTIDES; QUANTUM DOTS; TIME FACTORS; TRYPSIN;

EID: 84869456852     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac3028068     Document Type: Article

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