Molecular studies of the congenital malformation induced by Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage

Molecular Human Reproduction

Volumn 18, Issue 12, 2012, Pages 585-592

  Tang, L Y ^a   Li, L ^a   Borchert, A ^b   Lau, Clara B S ^c   Leung, P C ^c   Wang, C C ^a,c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chinese medicine; Congenital malformation; Largehead Atractylodes Rhizome; Pregnancy

Indexed keywords

CHINESE DRUG; LARGEHEAD ATRACTYLODES RHIZOME; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR 1; T BOX TRANSCRIPTION FACTOR 2; T BOX TRANSCRIPTION FACTOR 3; T BOX TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHINESE MEDICINE; CONGENITAL MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; FEMALE; FORELIMB; GENE EXPRESSION; GROWTH RETARDATION; HINDLIMB; HUMAN; LIMB DEVELOPMENT; MESODERM; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RHIZOME; SPONTANEOUS ABORTION;

ABORTION, THREATENED; ANIMALS; ATRACTYLODES; DRUGS, CHINESE HERBAL; EMBRYO, MAMMALIAN; FEMALE; FORELIMB; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MICE; POLYMERASE CHAIN REACTION; PREGNANCY; RHIZOME; T-BOX DOMAIN PROTEINS;

ANIMALIA; ATRACTYLODES; MUS;

EID: 84869405657     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gas034     Document Type: Article

References (39)

1. Aanhaanen WT, Brons JF, Domínguez JN, Rana MS, Norden J, Airik R, Wakker V, de Gier-de Vries C, Brown NA, Kispert A et al. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res 2009; 11:1267-1274.
2. Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC et al. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet 1997;3:311-315.
3. Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thormas J, Bollag RJ, Silver LM, Papaioannou VE. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dynam 1996;206:379-390.
4. Genschow E, Scholz G, Brown N, Piersma A, Brady M, Clemann N, Huusjkonen H, Paillard F, Bremer S, Becker K et al. Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study. In Vitro Mol Toxicol 2000;1:51-65.
5. Gibson-Brown JJ, Agulnik SI, Silver LM, Papaioannou VE. Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity. Mech Dev 1996;56:93-101.
6. Gilbert SF. Developmental Biology, 6th edn. Sunderland, MA: Sinauer Associates, 2000.
7. Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, Silver LM, Papaioannou VE. Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during hear development. Development 2004;131:5041-5052.
8. Harrison RG. Experiments on the development of the forelimb of ambystoma, a self-differentiating equipotential system. J Exp Zool 1918;25:413-461.
9. Horb M, Thomsen G. Tbx5 is essential for heart development. Development 1999;126:1739-1751.
10. King M, Arnold JS, Shanske A, Morrow BE. T-genes and limb bud development. Am J Med Genet A 2006;13:1407-1413.
11. Krabbenhoft KM, Fallon JF. The formation of leg or wing specific structures by leg bud cells grafted to the wing bud is influenced by proximity to the apical ridge. Dev Biol 1989;131:373-382.
12. Li L. Efficacy and safety of Chinese medicines for pregnancy. PhD thesis, Hong Kong: The Chinese University of Hong Kong, 2011.
13. Li L, Dou LX, Neilson JP, Leung PC, Wang CC. Adverse outcomes of Chinese medicines used for threatened miscarriage: a systematic review and meta-analysis. Hum Reprod Update 2012a;18:504-524.
14. Li L, Leung PC, Wang CC. Efficacy and safety of Chinese medicines for threatened miscarriage. In: Tranquilli Andrea L. (eds). Miscarriages: Causes, Symptoms and Prevention. New York: Nova Science, 2012b.
15. Li L, Tang LY, Man GCW, Yeung HY, Lau BS, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod 2011;26:3280-3288.
16. Liang LF (2008). The prevention of miscarriage using Chinese herbal medicine. Chin Med Times eJ 3 (in Chinese), http://www.chinesemedicinetimes.com/section/291/1/the_prevention_of_miscarriage_using_chinese_herbal_medicine (5 September 2011, date last accessed).
17. Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland HF, Scambler PJ et al. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 2001;6824:97-101.
18. Ma BZ, Liu RF, Du HL. Zhong Yi Fu Ke Xue, Vol. 8. Shanghai: The Science & Technology Press, 2006, 1-200 (in Chinese).
19. Naiche L, Harrelson Z, Kelly R, Papaioannou V. T-box genes in vertebrate development. Annu Rev Genet 2005;39:219-239.
20. National Phamacopoeia Committee. (2010) Chinese Pharmacopeia. 9th edn. Beijing: Chemical Industry Publishing House (in Chinese).
21. Sanz-Ezquerro JJ, Tickle C. Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development 2000; 127:4811-4823.
22. Saunders J. The proximal-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J Exp Zool 1948;108:363-404.
23. Saunders JW Jr, Cairns JM, Gasseling MT. The role of the apical ridge of ectoderm in the differentiation of the morphological structure and inductive specificity of limb parts in the chick. J Morphol 1957; 101:57-88.
24. Sionneau P (1995) Pao Zhi. An Introduction to the Use of Processed Chinese Medicinals. Boulder, CO: Blue Poppy Press.
25. Summerbell D, Lewis JH, Wolpert L. Positional information in chick limb morphogenesis. Nature 1973;244:492-495.
26. Suzuki T, Takeuchi J, Koshiba-Takeuchi K, Ogura T. Tbx genes specify posterior digit identity through Shh and BMP signaling. Dev Cell 2004; 1:43-53.
27. Tamayuki S, Koji K. Precartilage condensation during skeletal pattern formation. Develop Growth Differ 1990;3:243-248.
28. Todd GD, Loydie A, Virginia EP. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulanr mammary syndrome. Development 2003;130:2263-2273.
29. Ufer C, Wang CC, Fahling M, Schiebel H, Thiele BJ, Billett EE, Kuhn H, Borhert A. Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence binding factor 1 is essential for embryonic brain development. Gene Dev 2008;22:1835-1850.
30. Van Maele-Fabry G, Delhaise F, Goffloy F, Piacrd JJ. Developmental table of the early mouse postimplantation embryo. Toxicol In Vitro 1993; 7:719-725.
31. Wang CC, Chu KO, Chong WS, Li WY, Pang CP, Shum ASW, Lau TK, Rogers MS. Tea epigallocatechin-3-gallate increased 8-isoprostane level and induced caudal regression in developing rat embryos. Free Radic Biol Med 2007;43:519-527.
32. Wang CC, Borchert A, Ugun-Klusek A, Tang LY, Lui WT, Chu CY, Billett E, Kuhn H, Ufer C. Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis. J Biol Chem 2011;286:28322-28330.
33. Wang CC, Li L, Tang LY, Leung PC. Safety evaluation of commonly used Chinese medicines during pregnancy in mice. Hum Reprod 2012; 27:2488-2456.
34. Wessells NK. Tissue Interaction and Development. Menlo Park, CA: Benjamin Cummings, 1977.
35. Westfall RE. Herbal medicine in pregnancy and childbirth. Adv Ther 2001; 18:47-55.
36. Wilkinson DG. In Situ Hybridization: A Practical Approach. Oxford: IRL Press, 1992.
37. You SL. In: Fu Chan Ke Shi Yan Dong Wu Xue. Chinese Medicine Publisher of China, 2007;1:7-8.
38. Zeller R, López-Ríos J, Zuniga A. Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet 2009;12:845-858.
39. Zwilling E. Ectoderm-mesoderm relationship in the development of the chick embryo limb bud. J Exp Zool 1955;128:423-441.