Thioredoxin, the processivity factor, sequesters an exposed cysteine in the thumb domain of bacteriophage T7 DNA polymerase

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 39732-39741

  Tran, Ngoc Q ^a   Lee, Seung Joo ^a   Akabayov, Barak ^a   Johnson, Donald E ^a,b   Richardson, Charles C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NEW ENGLAND BIOLABS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING DOMAIN; BINDING EVENTS; COMPLEMENTARY STRAND; DISULFIDE LINKAGES; DNA POLYMERASE; ESCHERICHIA COLI THIOREDOXIN; PHYSICAL INTERACTIONS; POLYMERASE ACTIVITIES; PROCESSIVITY; SECONDARY STRUCTURES; SMALL ANGLE X-RAY SCATTERING; THIOREDOXINS; WILD TYPES;

BACTERIOPHAGES; BINDING ENERGY; DNA; ESCHERICHIA COLI; HYDROXYAPATITE; POLYMERS;

AMINO ACIDS;

CYSTEINE; DNA POLYMERASE; GENE 5 PROTEIN; SERINE; SINGLE STRANDED DNA; THIOREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIOPHAGE T7; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; DNA SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; WILD TYPE; X RAY CRYSTALLOGRAPHY;

BACTERIOPHAGE T7; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THIOREDOXINS; VIRAL PROTEINS;

ESCHERICHIA COLI;

EID: 84869233533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409235     Document Type: Article

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