AgRP neurons: A switch between peripheral carbohydrate and lipid utilization

EMBO Journal

Volumn 31, Issue 22, 2012, Pages 4252-4254

  Varela, Luis ^a   Horvath, Tamas L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AGOUTI RELATED PROTEIN; BRETAZENIL; DIPHTHERIA TOXIN; MELANOCORTIN RECEPTOR; TRIACYLGLYCEROL;

ADRENERGIC SYSTEM; ANIMAL MODEL; ANOREXIA; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BODY WEIGHT; CARBOHYDRATE METABOLISM; FOOD INTAKE; HYPOTHALAMUS; LIPID METABOLISM; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGOUTI-RELATED PROTEIN; ANIMALS; HYPOTHALAMUS; MALE;

MUS;

EID: 84869228783     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.287     Document Type: Article

References (11)

1. Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA, Bloom SR (2005) Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J 19:1680-1682 (Pubitemid 41429528)
2. Cone RD (2005) Anatomy and regulation of the central melanocor-tin system. Nat Neurosci 8:571-578 (Pubitemid 40594196)
3. Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL (2010) Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci 30:11815-11825
4. Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC (2005) Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci 8:1289-1291 (Pubitemid 41630413)
5. Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C (1997) Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756:283-286 (Pubitemid 27241638)
6. Joly-Amado A, Denis RGP, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S (2012) Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. EMBO J 31:4276-4288
7. Luquet S, Perez FA, Hnasko TS, Palmiter RD (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310:683-685 (Pubitemid 41528162)
8. Luquet S, Phillips CT, Palmiter RD (2007) NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28:214-225 (Pubitemid 46176250)
9. Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC et al (2007) The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 117:3475-3488 (Pubitemid 350097003)
10. Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB (2008) Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11:998-1000
11. Wu Q, Boyle MP, Palmiter RD (2009) Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137:1225-1234