Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

Biology of Reproduction

Volumn 87, Issue 1, 2012, Pages 25-

  Stanley, Joanna L ^a   Andersson, Irene J ^a   Hirt, Cassandra J ^a   Moore, Linn ^a   Dilworth, Mark R ^b   Chade, Alejandro R ^c   Sibley, Colin P ^b   Davidge, Sandra T ^a   Baker, Philip N ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Intrauterine growth restriction; Nitric oxide; Oxidative stress; Placental transport; Pregnancy

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; SUPEROXIDE; TEMPOL; AMINE OXIDE; AMINO ACID TRANSPORTER; ANTIOXIDANT; BIOMIMETIC MATERIAL; NOS3 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW VELOCITY; CONTROLLED STUDY; CROWN RUMP LENGTH; DENSITY; END DIASTOLIC VELOCITY; GESTATIONAL AGE; INTRAUTERINE GROWTH RETARDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UTERINE ARTERY; VELOCITY; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; FEMALE; FETUS DEVELOPMENT; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLACENTA; PREGNANCY; SPIN LABELING; VASCULARIZATION;

MUS;

AMINO ACID TRANSPORT SYSTEM A; ANIMALS; ANTIOXIDANTS; BIOMIMETIC MATERIALS; BLOOD FLOW VELOCITY; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; FEMALE; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PLACENTA; PREGNANCY; SPIN LABELS; SUPEROXIDE DISMUTASE; UTERINE ARTERY;

EID: 84869217075     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.096198     Document Type: Article

References (35)

1. Lewis G for the Confidential Enquiry into Maternal and Child Health (CEMACH). Saving Mothers' Lives: Reviewing Maternal Deaths To Make Motherhood Safer (2003-2005). London, UK: Royal College of Obstetricians and Gynaecologists; 2007.
2. McIntire DD, Bloom SL, Casey BM, Leveno KJ. Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med 1999; 340:1234-1238.
3. Thornton JG, Hornbuckle J, Vail A, Spiegelhalter DJ, Levene M. Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial. Lancet 2004; 364: 513-520.
4. Barker DJ. Fetal growth and adult disease. Br J Obstet Gynaecol 1992; 99: 275-276.
5. Naeye RL, Blanc W, Paul C. Effects of maternal nutrition on the human fetus. Pediatrics 1973; 52:494-503.
6. Gilbert WM, Young AL, Danielsen B. Pregnancy outcomes in women with chronic hypertension: a population-based study. J Reprod Med 2007; 52:1046-1051.
7. Ferrazzani S, Caruso A, De Carolis S, Martino IV, Mancuso S. Proteinuria and outcome of 444 pregnancies complicated by hypertension. Am J Obstet Gynecol 1990; 162:366-371.
8. Baschat AA. The fetal circulation and essential organs-a new twist to an old tale. Ultrasound Obstet Gynecol 2006; 27:349-354.
9. Moore RJ, Ong SS, Tyler DJ, Duckett R, Baker PN, Dunn WR, Johnson IR, Gowland PA. Spiral artery blood volume in normal pregnancies and those compromised by pre-eclampsia. NMR Biomed 2008; 21:376-380.
10. Moore RJ, Strachan BK, Tyler DJ, Duncan KR, Baker PN, Worthington BS, Johnson IR, Gowland PA. In utero perfusing fraction maps in normal and growth restricted pregnancy measured using IVIM echo-planar MRI. Placenta 2000; 21:726-732.
11. Hung TH, Skepper JN, Burton GJ. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol 2001; 159:1031-1043.
12. Wilcox CS, Pearlman A. Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev 2008; 60:418-469.
13. Davisson RL, Hoffmann DS, Butz GM, Aldape G, Schlager G, Merrill DC, Sethi S, Weiss RM, Bates JN. Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension 2002; 39:337-342.
14. Hoffmann DS, Weydert CJ, Lazartigues E, Kutschke WJ, Kienzle MF, Leach JE, Sharma JA, Sharma RV, Davisson RL. Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH/5 mouse model of preeclampsia. Hypertension 2008; 51:1058-1065.
15. Magness RR, Shaw CE, Phernetton TM, Zheng J, Bird IM. Endothelial vasodilator production by uterine and systemic arteries. II. Pregnancy effects on NO synthase expression.Am J Physiol 1997; 272:H1730-1740.
16. Nelson SH, Steinsland OS, Wang Y, Yallampalli C, Dong YL, Sanchez JM. Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancy. Circ Res 2000; 87:406-411.
17. Weiner C, Martinez E, Zhu LK, Ghodsi A, Chestnut D. In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during the guinea pig pregnancy. Am J Obstet Gynecol 1989; 161:1599-1605.
18. +/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells. Circ Res 2002; 91: 127-134.
19. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995; 377:239-242.
20. Hefler LA, Reyes CA, O'Brien WE, Gregg AR. Perinatal development of endothelial nitric oxide synthase-deficient mice. Biol Reprod 2001; 64: 666-673.
21. van der Heijden OW, Essers YP, Fazzi G, Peeters LL, De Mey JG, van Eys GJ. Uterine artery remodeling and reproductive performance are impaired in endothelial nitric oxide synthase-deficient mice. Biol Reprod 2005; 72:1161-1168.
22. Mu J, Adamson SL. Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation. Am J Physiol Heart Circ Physiol 2006; 291: H1421-1428.
23. Andersson IJ, Sankaralingam S, Davidge ST. Restraint stress up-regulates lectin-like oxidized low-density lipoprotein receptor-1 in aorta of apolipoprotein E-deficient mice. Stress 2010; 13:454-460.
24. Constancia M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, Dean W, Ferguson-Smith A, Sibley CP, Reik W, Fowden A. Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A 2005; 102:19219-19224.
25. Dilworth MR, Kusinski LC, Cowley E, Ward BS, Husain SM, Constancia M, Sibley CP, Glazier JD. Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport. Proc Natl Acad Sci U S A 2010; 107:3894-3899.
26. Chade AR, Bentley MD, Zhu X, Rodriguez-Porcel M, Niemeyer S, Amores-Arriaga B, Napoli C, Ritman EL, Lerman A, Lerman LO. Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs. J Am Soc Nephrol 2004; 15:1816-1825.
27. Iliescu R, Chade AR. Progressive renal vascular proliferation and injury in obese Zucker rats. Microcirculation 2010; 17:250-258.
28. Karowicz-Bilinska A, Kedziora-Kornatowska K, Bartosz G. Indices of oxidative stress in pregnancy with fetal growth restriction. Free Radic Res 2007; 41:870-873.
29. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 2006; 367:1145-1154.
30. Mariappan N, Soorappan RN, Haque M, Sriramula S, Francis J. TNFalpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. Am J Physiol Heart Circ Physiol 2007; 293:H2726-2737.
31. Sibley CP, Turner MA, Cetin I, Ayuk P, Boyd CA, D'Souza SW, Glazier JD, Greenwood SL, Jansson T, Powell T. Placental phenotypes of intrauterine growth. Pediatr Res 2005; 58:827-832.
32. Glazier JD, Cetin I, Perugino G, Ronzoni S, Grey AM, Mahendran D, Marconi AM, Pardi G, Sibley CP. Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatr Res 1997; 42:514-519.
33. Coan PM, Angiolini E, Sandovici I, Burton GJ, Constancia M, Fowden AL. Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice. J Physiol 2008; 586: 4567-4576.
34. Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W. Placentalspecific IGF-II is a major modulator of placental and fetal growth. Nature 2002; 417:945-948.
35. Nelson DM, Smith SD, Furesz TC, Sadovsky Y, Ganapathy V, Parvin CA, Smith CH. Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts. Am J Physiol Cell Physiol 2003; 284:C310-315.